A synthetic bone graft is described which is adapted to be received within a bone defect and which is structurally load-bearing. The bone graft comprises an entirely synthetic graft body corresponding in shape and size to the bone defect. The graft body is composed of a plurality of superimposed multilayered structures, each of the multilayered structures having a biopolymer layer joined to a biomineral layer to define an interface therebetween. The biomineral layer has a stiffness that is greater than that of the biopolymer layer, and the biopolymer layer has a toughness that is less than that of the biomineral layer.

The present invention relates to a method of manufacturing a sustained drug-release contact lens. More specifically, the present invention relates to a method of manufacturing a sustained drug-release contact lens, the method including: forming a body in which the body provides an outer shape of the lens and has a plurality of cavities configured to be recessed and spaced apart from each other by a predetermined distance along a side surface of the contact lens; and filling a drug and forming a closing part in which the cavities of the body formed at the forming the body are filled with the drug and respective closing parts closing the cavities are formed, wherein the closing part is made of a biodegradable material and each closing part is configured to open at a different time during wearing of the contact lens at the forming the body.

The present invention provides a method for producing a molded article including a step 1 of adding water to a composition including a structural protein, a step 2 of molding a water-containing composition obtained in the step 1, and a step 3 of drying the molded composition obtained in the step 2 to obtain the molded article.

A film of the present invention contains a polypeptide derived from spider silk proteins. The decomposition temperature of the film is 240 to 260 C. The film absorbs ultraviolet light having a wavelength of 200 to 300 nm and has a light transmittance of 85% or more at a wavelength of 400 to 780 nm. The film is transparent and colorless in a visible light region. A method for producing a film of the present invention includes: dissolving a polypeptide derived from spider silk proteins in a dimethyl sulfoxide solvent to prepare a dope; and cast-molding the dope on a surface of a base. Thus, the present invention provides a spider silk protein film that can be formed easily and has favorable stretchability, and a method for producing the same.

The present disclosure relates to patterned photonic crystals. Provided photonic crystals are large scale silk inverse opals with tunable, geometrically defined structural color. Provided photonic crystals exhibit structural color or a photonic band gap (PBG). Provided photonic crystals are is found to be highly sensitive to water vapor and UV irradiation. Provided multicolored photonic macro- or micro-patterns are shown by selectively applying water vapor or UV irradiation through a shadow mask. The present disclosure also provides methods for making and using the same.

The present disclosure relates to systems and methods for producing an extruded protein product. In particular, a system for making an extruded protein product using a system that includes a die including channel having a transverse cross section that is a continuous loop along at least a portion of the length of the die is disclosed.

The present invention relates to new acid resistant hard pharmaceutical capsules, a process for their manufacture and use of such capsules particularly but not exclusively for oral administration of pharmaceuticals, veterinary products, food and dietary supplements to humans or animals. The capsules of the invention are obtained by aqueous compositions comprising a water soluble film forming polymer and gellan gum in a mutual weight ratio of 4 to 15 weight parts of gellan gum for 100 weight parts of film forming polymer.

The present invention provides for concentrated aqueous silk fibroin solutions and an all-aqueous mode for preparation of concentrated aqueous fibroin solutions that avoids the use of organic solvents, direct additives, or harsh chemicals. The invention further provides for the use of these solutions in production of materials, e.g., fibers, films, foams, meshes, scaffolds and hydrogels.

A nucleic acid film fabrication method, includes: a mixing step in which a nucleic acid is added in powder form to distilled water or deionized water to prepare a mixed solution; a stirring step in which the mixed solution is stirred; a mixed solution application step in which the mixed solution is applied to a mold corresponding in shape to a final product of a nucleic acid film; and a drying step in which the mixed solution applied to the mold is dried to be formed into the nucleic acid film, wherein the mold has a groove formed thereon in a thickness direction thereof, such that the nucleic acid film passing through the drying step has a protrusion protruding from one surface thereof toward human skin to correspond to the groove.

The present invention is a printing device using multiple inks and a printing method using thereof, and more specifically, relates to a three-dimensional printing method of a printed product with a cross-sectional pattern comprising a step of providing different inks into each partitioned spaces and applying the same pressure condition to the inks retained in the ink-receiving part, thereby extruding the inks into a single extruding port to prepare and print an extruded ink product, using the printing device comprising an ink extruding member comprising an ink-receiving part receiving the multiple inks in each partitioned space, and an ink-extruding part equipped with a single passage in which the multiple inks received in the ink-receiving part are passed together.