The present disclosure provides methods and compositions for directed to synthetic block copolymer proteins, expression constructs for their secretion, recombinant microorganisms for their production, and synthetic fibers (including advantageously, microfibers) comprising these proteins that recapitulate many properties of natural silk. The recombinant microorganisms can be used for the commercial production of silk-like fibers.

The present disclosure is generally directed to a bio-ink system that can be used to print cellularized scaffolds for biomedical applications. In certain configurations, the ink has rheological properties suitable for extrusion-based printing techniques and adipose stem cells infused in the ink remain viable seven days after printing. The ink may comprise a mixture of alginate hydrogels, which provide the structural integrity of the printed scaffolds, and gelatin hydrogels, which support the cell proliferation. Borophosphate glass particles are added to the hydrogel mixture where they release Ca-ions that control the viscoelastic properties of the hydrogel before and after printing. Borophosphate glasses described herein promote significantly better ASC viability than previously employed glasses.

Systems, devices and methods are provided for fabricating anisotropic polymer materials. According to various embodiments, a fluidic device is employed to distribute a polymer solution and a flow-confining solution in order to generate a layered flow, where the layered flow is formed such that a polymer liquid sheet is sheathed on opposing sides by flow-confining liquid sheets. The fluidic device includes first and second fluid conduits, where the first fluid conduit receives the layered flow. The second fluid conduit has a reduced height relative to the first fluid conduit, such that the layered flow is constricted as it flows through the second fluid conduit. The constriction formed by the second flow conduit causes hydrodynamic focusing, reducing the thickness of the polymer liquid sheet, and inducing molecular alignment and anisotropy within the polymer liquid sheet as it is hardened and as strain is applied during extrusion of the sheet.

The present application relates to a recyclable material. The recyclable material comprises 30-97% by weight of cellulose material, 2-45% by weight of at least one protein binder, 1-20% by weight of at least one alcohol or ester and 0-45% by weight of at least one additive. Furthermore, the present application relates to a process for producing a recyclable material and to a molded part produced therefrom.

Provided is a molded article of a composition comprising a polypeptide which has more than 4.3 GPa of a bending elastic modulus and transparency.

A powdery-material feeding device is configured to feed a powdery material to a compression-molding machine configured to obtain a molded product by filling a die bore with the powdery material and to compress the powdery material with punches. The powdery-material feeding device includes a detector configured to detect a biologically-originated foreign matter mixedly contained in the powdery material to be fed to the compression-molding machine, and a controller configured to control to remove the powdery material mixedly containing the biologically-originated foreign matter detected by the detector to avoid feeding of the powdery material mixedly containing the biologically-originated foreign matter to the compression-molding machine, or to control to stop the feeding of the powdery material to the compression-molding machine.

Systems, devices and methods are provided for fabricating anisotropic polymer materials. According to various embodiments, a fluidic device is employed to distribute a polymer solution and a flow-confining solution in order to generate a layered flow, where the layered flow is formed such that a polymer liquid sheet is sheathed on opposing sides by flow-confining liquid sheets. The fluidic device includes first and second fluid conduits, where the first fluid conduit receives the layered flow. The second fluid conduit has a reduced height relative to the first fluid conduit, such that the layered flow is constricted as it flows through the second fluid conduit. The constriction formed by the second flow conduit causes hydrodynamic focusing, reducing the thickness of the polymer liquid sheet, and inducing molecular alignment and anisotropy within the polymer liquid sheet as it is hardened and as strain is applied during extrusion of the sheet.

The present disclosure provides methods and compositions for directed to synthetic block copolymer proteins, expression constructs for their secretion, recombinant microorganisms for their production, and synthetic fibers (including advantageously, microfibers) comprising these proteins that recapitulate many properties of natural silk. The recombinant microorganisms can be used for the commercial production of silk-like fibers.

The present invention relates to an aqueous binder composition for mineral fibers comprisingat least one hydrocolloid, at least one fatty acid ester of glycerol.

The present invention discloses compositions and methods for repair and reconstruction of defects and injuries to soft tissues. Some aspects of the disclosure provide methods for corneal reconstruction by applying an engineered bioadhesive, glycidyl methacrylate-substituted gelatin and a visible light activated photoinitiator in presence of visible light to the corneal defect.