A biological scaffold in the present invention comprises a main body, a biological material layer, and an optional tissue adhesive layer. The main body at least has a non-constituted collagen matrix. The biological material layer is coated at least on a surface of the main body, and the tissue adhesive layer is disposed at least on another surface of the main body. When the biological scaffold is adhered to a tissue through the tissue adhesive layer, a plurality of cells move from the tissue to either the adhesive layer or the biological material layer for tissue repairing or regeneration.

The invention generally relates to systems, methods, and devices for ex vivo organ care. More particularly, in various embodiments, the invention relates to caring for a liver ex vivo at physiologic or near-physiologic conditions.

Provided is an antimicrobial composition comprised of at least one degradation product of oxidized cellulose (OC), such as oxidized regenerate cellulose (ORC), and minocycline, methods of preparation thereof and uses thereof.

Provided is an antimicrobial composition comprised of at least one degradation product of oxidized cellulose (OC), such as oxidized regenerate cellulose (ORC), and minocycline, methods of preparation thereof and uses thereof.

The present invention provides a mixture that serves for the preservation of Coleoptera to preserve its exoskeleton and its ornamental appearance; reinforce the exoskeleton of the coleopterous to minimize their fragility; improve the preservation of the insect by making an internal preparation that prevents rupture of the exoskeleton caused by blows, manipulation or pressure on it.

The present invention provides a mixture that serves for the preservation of Coleoptera to preserve its exoskeleton and its ornamental appearance; reinforce the exoskeleton of the coleopterous to minimize their fragility; improve the preservation of the insect by making an internal preparation that prevents rupture of the exoskeleton caused by blows, manipulation or pressure on it.

Erythrocyte simulating particles, a preparation method therefor, and a quality control or calibrator containing the erythrocyte simulated particles. The method for preparing erythrocyte simulating particles includes: performing oxidization and fixation treatments on erythrocytes by using an erythrocyte treatment solution that has a pH of 5.0-9.0 and an osmotic pressure of 300-800 Osm/kg.Math.H.sub.2O, wherein the erythrocyte treatment solution contains at least one oxidization agent selected from halogen oxygen acid salts and at least one fixation agent selected from aldehydes or acids; and washing the erythrocytes treated by the erythrocyte treatment solution and suspending the same in a preservation solution. The described method uses an environmentally friendly halogen oxygen acid salt as an oxidant, to obtain erythrocyte simulating particles that can be stored stably for a long time and have properties similar to natural erythrocyte particles in an erythrocyte detection channel.

The present innovation relates to the use of Tilapia skin, processed in several steps, on the basis of glycerol in concentrations ranging from 50% to 99% in a Type 5 and 7 Clean Room environments and, in certain cases, when the microbial count is high, it is necessary to have supplementary radio-sterilization with Gamma Irradiation. The skin can be used as an occlusive biological dressing in skin injuries, such as burns and acute or chronic wounds.

The present innovation relates to the use of Tilapia skin, processed in several steps, on the basis of glycerol in concentrations ranging from 50% to 99% in a Type 5 and 7 Clean Room environments and, in certain cases, when the microbial count is high, it is necessary to have supplementary radio-sterilization with Gamma Irradiation. The skin can be used as an occlusive biological dressing in skin injuries, such as burns and acute or chronic wounds.

The present disclosure provides a method of covalently modifying a biological macromolecule, the method comprising subjecting a reaction mixture comprising: (a) a biological macromolecule comprising one or more thiol groups; and (b) a molecule comprising one or more olefin or alkyne moieties to a radical reaction under conditions sufficient to produce the covalently modified biological macromolecule. The present disclosure also provides a method of covalently modifying a biological macromolecule, the method comprising subjecting a reaction mixture comprising: (a) a molecule comprising one or more thiol groups; and (b) a biological macromolecule comprising one or more olefin or alkyne moieties to a radical reaction under conditions sufficient to produce the covalently modified biological macromolecule. The present disclosure further provides a covalently modified biological macromolecule prepared by any of the disclosed methods. The covalently modified biological macromolecules may be further crosslinked to form a scaffold.