The present invention discloses an anti-hair loss and hair growth integrated core-shell microneedle patch, comprising a backing and a core-shell microneedle array attached to one side of the backing, the core-shell microneedle array comprises a plurality of microneedles arranged on the backing to form an array, each microneedle comprises a shell substrate material and an internal core, and the shell substrate material is loaded with nano-enzyme for removing excessive active oxygen. The present invention uses an anti-hair loss and hair growth integrated core-shell microneedle patch of the above mentioned structure, wherein the shell substrate material is rapidly degraded after the microneedle patch is applied to the skin, the nano-enzyme loaded by the shell substrate material can be passively released to remove active oxygen and promote angiogenesis in the microenvironment around hair follicles, the internal core of the microneedle is loaded with mesenchymal stem cell-derived exosomes, and the internal exosomes are released and conveyed to hair follicle niches after the shell substrate material is degraded, so that improvement of pigmentation and promotion of hair regrowth are possible.

A functional polymeric cutting edge structure and methods for manufacturing cutting edge structures using polymeric materials are provided. A razor blade for use in a razor cartridge or a blade box for assembly in a razor cartridge frame may be formed using the present invention.

A solidification substrate assembly for making a three-dimensional object from a solidifiable material includes a solidification substrate assembly. In certain examples, the solidifiable material solidifies in contact with the solidification substrate, and the tilting of the substrate and/or or the use of a peeling member facilitates separation of the substrate from the solidified material. In other examples, the solidification substrate assembly includes a film that is adjacent to a rigid or semi-rigid layer. The solidifiable material solidifies in contact with the film, and a peeling member peels the film away from the solidified material. Intelligent solidification substrate assemblies are also described in which a force sensor determines when to expose the solidifiable material to solidification energy and/or whether to use a peeling member to separate the solidification substrate from a solidified objection section.

A method for forming a prosthesis comprising a bone-like portion and a cartilage-like portion can comprise additively manufacturing a first positive mold in accordance with a portion of a first three-dimensional model of a portion of a bone. A first negative mold can be formed from the first positive mold. The bone-like portion can be created within the first negative mold. A second positive mold of the bone and a cartilage can be additively manufactured from a second three-dimensional model. A portion of the second three-dimensional model can correspond to a portion of the first three-dimensional model. A second negative mold can be formed from the second positive mold. The bone-like portion can be positioned in the second negative mold so that the second negative mold and the bone-like portion can define a cartilage space that can be filled with a material to form the cartilage-like portion of the prosthesis.

The purpose of the present invention is to provide a heat-sealing device capable of preventing problems associated with cap sealing performance and/or sensation of the cap being open due to an inappropriate cap temperature. For this purpose, this heat-sealing device (10), which is used in a manufacturing apparatus (100) for manufacturing a product for which an opening part (1A: mouth part) of a container (1) is sealed with a cap (2), is provided with: a pressing plate (5) which is disposed on a path along which the containers (1) move; a heating unit (3) and sealing heads (4) for pressing the caps (2) sealing the container (1), the heating unit (3) and sealing heads (4) being arranged on the pressing plate (5); a temperature measurement device (7) for measuring the temperatures of the sealing heads (4); and a control device (8: control unit) for transmitting control signals to a container conveyance drive source (for example, inverter) in accordance with the measurement results from the temperature measurement device (7).

The purpose of the present invention is to provide a heat-sealing device capable of preventing problems associated with cap sealing performance and/or sensation of the cap being open due to an inappropriate cap temperature. For this purpose, this heat-sealing device (10), which is used in a manufacturing apparatus (100) for manufacturing a product for which an opening part (1A: mouth part) of a container (1) is sealed with a cap (2), is provided with: a pressing plate (5) which is disposed on a path along which the containers (1) move; a heating unit (3) and sealing heads (4) for pressing the caps (2) sealing the container (1), the heating unit (3) and sealing heads (4) being arranged on the pressing plate (5); a temperature measurement device (7) for measuring the temperatures of the sealing heads (4); and a control device (8: control unit) for transmitting control signals to a container conveyance drive source (for example, inverter) in accordance with the measurement results from the temperature measurement device (7).

The pressing of an article is achieved with a closed-loop feedback press. The closed-loop feedback press is effective to measure an amount of pressure applied and adjust the pressure to achieve a prescribed amount of compression on the article. Further, the press may leverage a closed-loop feedback system to maintain a consistent temperature of one or more platens. The press is able to adjust a pressure applied one or more times during a pressing operation to accelerate a temperature change in the pressed article while reducing the pressure applied as the temperature approaches a target temperature to limit unintentional deformation and bleeding of the pressed material of the article.

A multi-layer elastomeric tooling for the manufacturing of composite structures is disclosed. The tooling comprises an elastomeric base material with an outer layer of fluoroelastomer. The base material can, in certain embodiments, be selected for its mechanical or thermal performance or low cost without the limitation of being a contact material. The outer material can, in various embodiments, have inferior mechanical properties, or durometers different than the base material or can be a contact or barrier material.

A method of manufacturing a microstructure comprises printing a positive mold structure, filling the positive mold structure with a second material to form an elastically deformable negative mold structure, filling the negative mold structure with a third material to form the microstructure, and releasing the microstructure from the negative mold structure. Advantageously, the negative mold structure can be stretched to facilitate the release of the microstructure. For example, the microstructure comprises a chamber with capped micropillars for the generation and/or analysis of muscle tissue.

Provided are a transdermal absorption sheet capable of achieving control of the dissolution rate and suppression of diffusion of a drug, and a method of producing the same. A transdermal absorption sheet includes a sheet portion, and a plurality of needle-like protruding portions formed by a plurality of frustum portions arranged on the sheet portion and needle portions arranged on the frustum portions, in which at least one of the needle-like protruding portions has a cavity portion extending from the sheet portion to the frustum portion.