Methods and apparatus for sterilizing and filling vessels which are kept in a sterile environment while being filled are capped before filling and immediately thereafter are ready to be displaced into a potentially contaminating environment while retaining a predetermined SAL are disclosed. Such vessels can be syringes use for dispensing Avastin or conventional syringes. Also method and apparatus for making an eye drop bottle using a conventional medical syringe which can be used in kits made according to the present invention are disclosed. In addition, a method for modifying conventional eye drop bottles for use in kits made according to the instant invention is disclosed. Further, a method for linking single convenience kits to form increased numbers of vessels filled by the same single act, used to fill a single convenience kit, is also disclosed.

The present invention relates to a device comprising a cassette (1) having an opening (2) in an axial direction of the cassette (1) and a support surface (3) transverse to the axial direction and extending around the opening (2) of the cassette (1), the cassette (1) being capable of receiving a cup in the opening with a outwardly extending flange of the cup supported by the support surface (3), and a supporting plate (4) having an opening in a normal direction of the supporting plate (4), wherein the cassette (1) comprises a resilient or flexible material, and a slot in which a part of the supporting plate (4) is received in close contact without cavities.

In certain embodiments, a vial adaptor comprises a housing configured to couple the adaptor with a vial, an access channel, a regulator channel, and a regulator assembly. The access channel is configured to facilitate withdrawal of fluid from the vial when the adaptor is coupled to the vial. The regulator channel is configured to facilitate a flow of a regulating fluid from the regulator assembly to compensate for changes in volume of a medical fluid in the vial. In some embodiments, the regulator assembly includes a flexible member configured to expand and contract in accordance with changes in the volume of the medical fluid in the vial. In some embodiments, the flexible member is substantially free to expand and contract. In some embodiments, the flexible member is not partly or completely located in a rigid enclosure.

An aerosol product comprising an aerosol container comprising a container body and an aerosol valve fixed to an opening of the container body, and an aqueous concentrate and a propellant being filled in the aerosol container, wherein the aqueous concentrate comprises an active ingredient having reactivity with oxygen, and an inert ingredient is present in at least a part of an injection passage of the aerosol valve, even though the aqueous concentrate comprising an active ingredient having reactivity with oxygen is filled, oxidation of the active ingredient is inhibited in the aerosol valve, and an aerosol product that can be stored stably for a long period of time and a method for manufacturing the same can be provided.

An aerosol product comprising an aerosol container comprising a container body and an aerosol valve fixed to an opening of the container body, and an aqueous concentrate and a propellant being filled in the aerosol container, wherein the aqueous concentrate comprises an active ingredient having reactivity with oxygen, and an inert ingredient is present in at least a part of an injection passage of the aerosol valve, even though the aqueous concentrate comprising an active ingredient having reactivity with oxygen is filled, oxidation of the active ingredient is inhibited in the aerosol valve, and an aerosol product that can be stored stably for a long period of time and a method for manufacturing the same can be provided.

A syringe (18) has a longitudinal body (28) with an interior (228) in which a pharmaceutical substance is arranged, a needle connected to one longitudinal end of the body (228) and a rigid needle shield (38) encasing the needle. The rigid needle shield (38) is essentially water vapour tight. The syringe (18) according to the invention allows for preventing needle clogging and, thus, proper provision of pharmaceuticals, particularly by subcutaneous, intramuscular or ocular injection.

A flexible multi-chamber bag for storing and reconstituting parenteral nutrition solutions is disclosed. The flexible multi-chamber bag comprises two first peelably sealing walls between the two polymer films extending from the top edge to the bottom edge and separating the first bag into a first chamber, a second chamber and a third chamber, wherein the first chamber is between the second chamber and the third chamber; and at least one of the two first peelably sealing walls split into a second plurality of second peelably sealing walls and the second plurality of the second sealing walls sealed to the bottom edge to form a fourth chamber.

Systems and methods for distributing a filling fluid are discussed. More particularly an exemplary filling system may include a reservoir holding a filling fluid for distribution. The filling system may also include a pump and filling nozzle fluidly coupled to the reservoir. A processor executes a filling module that when executed receives at least one input fluid property of the filling fluid and generates at least one set of operating parameters for controlling operation of the pump during a filling operation based at least in part on the fluid property. The generated set of operating parameters enable control of the pump to distribute the filling fluid through the filling nozzle, such that a fluid interface with a stable resting profile forms in the filling fluid in the filling nozzle adjacent to the nozzle opening after the filling fluid is distributed from the filling nozzle.

Systems and methods for distributing a filling fluid are discussed. More particularly an exemplary filling system may include a reservoir holding a filling fluid for distribution. The filling system may also include a pump and filling nozzle fluidly coupled to the reservoir. A processor executes a filling module that when executed receives at least one input fluid property of the filling fluid and generates at least one set of operating parameters for controlling operation of the pump during a filling operation based at least in part on the fluid property. The generated set of operating parameters enable control of the pump to distribute the filling fluid through the filling nozzle, such that a fluid interface with a stable resting profile forms in the filling fluid in the filling nozzle adjacent to the nozzle opening after the filling fluid is distributed from the filling nozzle.

The invention relates to a device for welding a connection region of a film to a connection part having an axial direction. In the case of conventional devices, there is the risk of steep workpiece edges causing uncontrolled weak spots in the film and in the weld seam. According to the invention, the film is extended in a controlled manner such that the film has a length reserve. The film is extended in such a way that the film has a deformation cross-section that runs out such that the deformation is not visible on the final product. In this connection, the invention further relates to a use of a film, to a method for welding, to a method for producing bags, to a system for producing bags, and to a bag.