The invention relates to matrix and layer compositions comprising a first polymer. The matrix and layer compositions are useful in the delivery of bioactives. In particular, the matrices and layers may have advantageous properties including mechanical properties and protection of bioactives and may also provide for pH-dependent release of a bioactive.

A specific type of digestibility in a companion animal can be improved by adjusting the diet of the animal to increase the amount of a compound which positively or negatively modulates the specific type of digestibility or adjusting the diet of the animal to decrease the amount of a compound which positively or negatively modulates the specific type of digestibility. The specific type of digestibility can be one or more of organic matter digestibility, dry matter digestibility, fiber digestibility, energy digestibility, fat digestibility, or protein digestibility.

Bone mineral content, 25(OH) vitamin D3, or 1,25(OH).sub.2 vitamin D3 in a companion animal can be improved by adjusting the diet of the animal to increase the amount of a compound which positively or negatively modulates the bone mineral content, 25(OH) vitamin D3, or 1,25(OH).sub.2 vitamin D3 or adjusting the diet of the animal to decrease the amount of a compound which positively or negatively modulates the bone mineral content, 25(OH) vitamin D3, or 1,25(OH).sub.2 vitamin D3.

The present invention provides methyl- and trifluoromethyl-substituted pyrrolopyridines, pharmaceutical compositions thereof, methods of modulating ROR activity and/or reducing the amount of IL-17 in a subject, and methods of treating various medical disorders using such pyrrolopyridines and pharmaceutical compositions thereof.

Described herein are pet food compositions comprising a Camellia extract obtained from the tissue of a tea which is greater than about 40% oxidized; and a fiber component, wherein the Camellia extract and the fiber component are present in an amount effective to provide, after about 24 hours post-ingestion, a fecal hydrogen sulfide concentration of less than 450 mg/L, and a colonic lumen pH of less than 5.0. Methods of making and using these pet food compositions are also described.

A pet food feeding system for effectively distributing and dispensing food to an animal in a controlled manner. The pet food feeding system generally includes a container having a floor, a sidewall extending upwardly from the floor, and an upper opening defined by an upper perimeter of the sidewall. The floor and sidewall define an interior space that receives a volume of dry kibble food pellets. The floor includes a plurality of projections that extend upwardly into the interior space where the pellets fit between thereof. A top closure may be attached to the upper perimeter of the sidewall in a sealed manner to seal the dry kibble food pellets within the interior space.

A pet food feeding system for effectively distributing and dispensing food to an animal in a controlled manner. The pet food feeding system generally includes a container having a floor, a sidewall extending upwardly from the floor, and an upper opening defined by an upper perimeter of the sidewall. The floor and sidewall define an interior space that receives a volume of dry kibble food pellets. The floor includes a plurality of projections that extend upwardly into the interior space where the pellets fit between thereof. A top closure may be attached to the upper perimeter of the sidewall in a sealed manner to seal the dry kibble food pellets within the interior space.

White blood cells and/or neutrophils in a companion animal can be improved by adjusting the diet of the animal to increase the amount of a compound which positively or negatively modulates the white blood cells and/or neutrophils or adjusting the diet of the animal to decrease the amount of a compound which positively or negatively modulates the white blood cells and/or neutrophils.

The present disclosure concerns embodiments of a combination and/or composition comprising bacillus, and yucca, quillaja or both. Embodiments of methods of making and using the combination and/or composition also are disclosed herein. In some embodiments, the combination and/or composition may be used to improve feed conversion rates in animals. In some embodiments the animals are avians; in other embodiments, the animals are non-avians. Embodiments of the disclosed combination can comprise a first composition comprising Quillaja saponaria, Yucca schidigera, or both, and Bacillus coagulans. Embodiments of the disclosed composition can comprise Quillaja saponaria, Yucca schidigera, or both, and Bacillus coagulans.

The present disclosure concerns embodiments of a combination and/or composition comprising bacillus, and yucca, quillaja or both. Embodiments of methods of making and using the combination and/or composition also are disclosed herein. In some embodiments, the combination and/or composition may be used to improve feed conversion rates in animals. In some embodiments the animals are avians; in other embodiments, the animals are non-avians. Embodiments of the disclosed combination can comprise a first composition comprising Quillaja saponaria, Yucca schidigera, or both, and Bacillus coagulans. Embodiments of the disclosed composition can comprise Quillaja saponaria, Yucca schidigera, or both, and Bacillus coagulans.