Provided is a method of mixing first and second liquids having mutual solubility inside a mixing flow channel formed by a micro flow channel. This method includes: causing the first and second liquids to be joined to each other inside the mixing flow channel; and forming a slug flow, in which mixing subject cells (60) formed by the joined liquid and insoluble fluid cells (63) formed by an insoluble fluid are alternately arranged, inside a flow channel at the downstream side of an insoluble fluid supply position in a manner such that the insoluble fluid having insolubility with respect to both mixing subject liquids is supplied to the joined liquid flowing through the flow channel in a direction intersecting the flow channel so that the joined liquid is divided with a gap therebetween, thereby mixing the first mixing subject liquid and the second mixing subject liquid contained in each mixing subject cell inside the downstream flow channel.

Provided is a method of mixing first and second liquids having mutual solubility inside a mixing flow channel formed by a micro flow channel. This method includes: causing the first and second liquids to be joined to each other inside the mixing flow channel; and forming a slug flow, in which mixing subject cells (60) formed by the joined liquid and insoluble fluid cells (63) formed by an insoluble fluid are alternately arranged, inside a flow channel at the downstream side of an insoluble fluid supply position in a manner such that the insoluble fluid having insolubility with respect to both mixing subject liquids is supplied to the joined liquid flowing through the flow channel in a direction intersecting the flow channel so that the joined liquid is divided with a gap therebetween, thereby mixing the first mixing subject liquid and the second mixing subject liquid contained in each mixing subject cell inside the downstream flow channel.

Methods for mass production of new microfluidic devices are described. The microfluidic devices may include an array of micro-needles with open channels in fluid communication with multiple reservoirs located within a substrate that supports the micro-needles. The micro-needles are configured so as to sufficiently penetrate the skin in order to collect or sample bodily fluids and transfer the fluids to the reservoirs. The micro-needles may also deliver medicaments into or below the skin.

A product includes an elongated carbon-containing pillar having a bottom and a tip opposite the bottom. The width of the pillar measured 1 nm below the tip is less than 700 nm. A method includes masking a carbon-containing single crystal for defining masked regions and unmasked regions on the single crystal. The method also includes performing a plasma etch for removing portions of the unmasked regions of the single crystal, thereby defining a pillar in each unmasked region, and performing a chemical etch on the pillars at a temperature between 1200° C. and 1600° C. for selectively reducing a width of each pillar.

A method of manufacturing a plurality of through-holes (132) in a layer of material by subjecting the layer to directional dry etching to provide through-holes (132) in the layer of material; For batch-wise production, the method comprises after a step of providing a layer of first material (220) on base material and before the step of directional dry etching, providing a plurality of holes at the central locations of pits (210), etching base material at the central locations of the pits (210) so as to form a cavity (280) with an aperture (281), depositing a second layer of material (240) on the base material in the cavity (280), and subjecting the second layer of material (240) in the cavity (280) to said step of directional dry etching using the aperture (281) as the opening (141) of a shadow mask.

Systems, methods, and devices for analyzing small volumes of fluidic samples, as a non-limiting example, less than twenty microliters are provided. The devices are configured to make a first sample reading, for example, measure an energy property of the fluid sample, for example, osmolality, make a second sample reading, for example, detecting the presence or concentration of one or more analytes in the fluid sample, or make both the first sample reading and the second sample reading, for example, measuring the energy property of the fluid sample as well as detecting the presence or concentration of one or more analytes in the fluid sample.

Systems, methods, and devices for analyzing small volumes of fluidic samples, as a non-limiting example, less than twenty microliters are provided. The devices are configured to make a first sample reading, for example, measure an energy property of the fluid sample, for example, osmolality, make a second sample reading, for example, detecting the presence or concentration of one or more analytes in the fluid sample, or make both the first sample reading and the second sample reading, for example, measuring the energy property of the fluid sample as well as detecting the presence or concentration of one or more analytes in the fluid sample.

Disclosed are methods for determining and classifying aircraft air contaminants comprising one or more of: turbine engine oil, hydraulic fluid and deicing fluid using contaminant analyzers comprising a contaminant collector comprising a membrane and a heater vaporizing the contaminants; a gravimetric sensor generating a response when contaminant mass is added to or removed from the sensor, the sensor receiving contaminants desorbed from the heated membrane; a frequency measurement device, measuring the response generated by the sensor as the contaminant is added to and removed from the sensor; a computer readable medium bearing a contaminant recognition program and calibration data; a processor executing the program, the program including a module classifying contaminants by type, and a module using the data for comparison with magnitude of response generated by the sensor to calculate contaminant concentration; and, a pump, generating flow of air through the collector before and after the membrane is heated.

An apparatus for controlling flow of ER fluid. The apparatus has a first channel 10 for conveying carrier fluid 1 of a first dielectric constant and droplets 2 of a second dielectric constant in the carrier fluid. The apparatus further comprises a second channel 20 conveying the ER fluid and a first conductor 100 for conveying an electrical potential from the second channel to the first channel. A circuit 61 is provided for applying potential difference between the first and second channels. When a droplet is present in the first channel, the ER fluid is solidified in the second channel; when no droplet is present, the ER fluid flows as liquid in the second channel. Therefore the apparatus acts as an IF gate. Arrangements for other types of fluidic logic gate are also disclosed.

A preferred conformal penetrating multi electrode array includes a plastic substrate that is flexible enough to conform to cortical tissue. A plurality of penetrating semiconductor micro electrodes extend away from a surface of the flexible substrate and are stiff enough to penetrate cortical tissue. Electrode lines are encapsulated at least partially within the flexible substrate and electrically connected to the plurality of penetrating semiconductor microelectrodes. The penetrating semiconductor electrodes preferably include pointed metal tips. A preferred method of fabrication permits forming stiff penetrating electrodes on a substrate that is very flexible, and providing electrical connection to electrode lines within the substrate.