Described herein is an operationally simple, one-pot solid-supported preparation of saturated stapled peptides. Following completion of ruthenium-catalysed metathesis, solid-phase transfer hydrogenation was achieved using triethylhydrosilane at elevated temperatures. The utility of the method has been demonstrated on 14- and 16-mer peptides to yield the corresponding cyclic a-helix stabilised stapled peptides.

Described herein is an operationally simple, one-pot solid-supported preparation of saturated stapled peptides. Following completion of ruthenium-catalysed metathesis, solid-phase transfer hydrogenation was achieved using triethylhydrosilane at elevated temperatures. The utility of the method has been demonstrated on 14- and 16-mer peptides to yield the corresponding cyclic a-helix stabilised stapled peptides.

A metal bronze compound is provided. The metal bronze compound is a compound represented by formula (1) below. In formula (1), “A” represents at least one type of cation. “M” represents at least two types of ions selected from a transition metal and a metalloid. “x” represents the sum of the number of the at least one type of cation used as “A”. “y” represents the sum of the number of the at least two types of ions selected from the transition metal and the metalloid used as “M”. “z” represents the number of oxygen ion. The values of “x”, “y” and “z” balance the charge number of formula (1).
A.sub.xM.sub.yO.sub.z  (1)

The invention is directed to a composition of metal particles and methods of manufacturing and using the composition in the treatment of microbial infections and cancer. The particles can be nanoparticles having coupled thereto at least one of a surfactant, an antibiotic, and a drug. The particles of the invention achieve enhanced stability, enhanced cytotoxicity, and enhanced antimicrobial activity through novel combinations of metals, surfactants, antibiotics, and drugs.

The invention is directed to a composition of metal particles and methods of manufacturing and using the composition in the treatment of microbial infections and cancer. The particles can be nanoparticles having coupled thereto at least one of a surfactant, an antibiotic, and a drug. The particles of the invention achieve enhanced stability, enhanced cytotoxicity, and enhanced antimicrobial activity through novel combinations of metals, surfactants, antibiotics, and drugs.

Cathode materials for lithium ion batteries, lithium ion batteries incorporating the cathode materials, and methods of operating the lithium ion batteries are provided. The materials are composed of lithium metal oxides that include two different metals.

Solid-state lithium ion electrolytes of lithium potassium element oxide based compounds are provided which contain an anionic framework capable of conducting lithium ions. The element atoms are Ir, Sb, I Nb and W. An activation energy of the lithium potassium element oxide compounds is from 0.15 to 0.50 eV and conductivities are from 10.sup.3 to 22 mS/cm at 300K. Compounds of specific formulae are provided and methods to alter the materials with inclusion of aliovalent ions shown. Lithium batteries containing the composite lithium ion electrolytes are also provided. Electrodes containing the lithium potassium element oxide based materials and batteries with such electrodes are also provided.

Solid-state lithium ion electrolytes of lithium potassium element oxide based compounds are provided which contain an anionic framework capable of conducting lithium ions. The element atoms are Ir, Sb, I Nb and W. An activation energy of the lithium potassium element oxide compounds is from 0.15 to 0.50 eV and conductivities are from 10.sup.3 to 22 mS/cm at 300K. Compounds of specific formulae are provided and methods to alter the materials with inclusion of aliovalent ions shown. Lithium batteries containing the composite lithium ion electrolytes are also provided. Electrodes containing the lithium potassium element oxide based materials and batteries with such electrodes are also provided.

An intermediate temperature solid oxide fuel cell (IT-SOFC) includes an anode layer, an electrolyte adjacent to the anode layer, and a cathode layer adjacent to the electrolyte and including a material of formula (I) or (II): Sr.sub.2OsO.sub.4 (I) or Ba.sub.2MO.sub.4 (II), where M is a transition metal or post-transition metal.

An intermediate temperature solid oxide fuel cell (IT-SOFC) includes an anode layer, an electrolyte adjacent to the anode layer, and a cathode layer adjacent to the electrolyte and including a material of formula (I) or (II): Sr.sub.2OsO.sub.4 (I) or Ba.sub.2MO.sub.4 (II), where M is a transition metal or post-transition metal.