Fusogenic compounds, and compositions and methods of use thereof. The fusogenic compounds can be used for making nanoparticle compositions for use in biopharmaceuticals and therapeutics. More particularly, compounds, compositions and methods are to provide nanoparticles to incorporate or encapsulate active agents, to deliver and distribute the active agents to cells, tissues, organs, and subjects.

Fusogenic compounds, and compositions and methods of use thereof. The fusogenic compounds can be used for making nanoparticle compositions for use in biopharmaceuticals and therapeutics. More particularly, compounds, compositions and methods are to provide nanoparticles to incorporate or encapsulate active agents, to deliver and distribute the active agents to cells, tissues, organs, and subjects.

A quaternary ammonium compound of formula (I): ##STR00001##
wherein R.sup.0, R.sup.1, R.sup.2 and R.sup.3 is each independently an optionally substituted hydrocarbyl group, X is a linking group, R.sup.4 is an optionally substituted alkylene group, R.sup.5 is hydrogen or an optionally substituted alkyl, alkenyl or aryl group, and n is 0 or a positive integer, provided that n is not 0 when R.sup.5 is hydrogen.

The present disclosure concerns inhibitors of Norovirus protease that are suitable for use against any genotype of Norovirus, including at least GII.4 Norovirus proteases. In particular embodiments, specific compositions are encompassed, including their use for prevention or treatment of Norovirus infection in an individual.

The present disclosure concerns inhibitors of Norovirus protease that are suitable for use against any genotype of Norovirus, including at least GII.4 Norovirus proteases. In particular embodiments, specific compositions are encompassed, including their use for prevention or treatment of Norovirus infection in an individual.

A quaternary ammonium compound of formula (I): wherein R.sup.0, R.sup.1, R.sup.2 and R.sup.3 is each independently an optionally substituted hydrocarbyl group, X is a linking group, R.sup.4 is an optionally substituted alkylene group, R.sup.5 is hydrogen or an optionally substituted alkyl, alkenyl or aryl group, and n is 0 or a positive integer, provided that n is not 0 when R.sup.5 is hydrogen. ##STR00001##

This disclosure relates to N-substituted Pd(II)-N-heterocyclic carbene-pyridine complexes, methods of preparing the complexes, and methods of using the complexes in Sonogashira coupling reactions.

A quaternary ammonium compound of formula (I): (I) wherein R.sup.0, R.sup.1, R.sup.2 and R.sup.3 is each independently an optionally substituted hydrocarbyl group, X is a linking group, R.sup.4 is an optionally substituted alkylene group, R5 is hydrogen or an optionally substituted alkyl, alkenyl or aryl group, and n is 0 or a positive integer, provided that n is not 0 when R5 is hydrogen. ##STR00001##

Provided herein are, inter alia, compounds inhibiting poly(ADP-ribose) Glycohydrolase (PARG) in a cancer cell and methods of treating cancer using compounds of the invention.

A quaternary ammonium compound of formula (I): wherein R.sup.0, R.sup.1, R.sup.2 and R.sup.3 is each independently an optionally substituted hydrocarbyl group, X is a linking group, R.sup.4 is an optionally substituted alkylene group, R.sup.5 is hydrogen or an optionally substituted alkyl, alkenyl or aryl group, and n is 0 or a positive integer, provided that n is not 0 when R.sup.5 is hydrogen.

##STR00001##