The present invention relates to a new class of steroid saponins that have interesting biological activity. In particular the present invention relates to a class of steroid saponins in which the sugar moiety has been selectively functionalised to introduce a moiety that contains either, (i) a hydrogen ion donor, (ii) a hydrogen ion acceptor or (iii) a combination thereof. These new, water-soluble compounds are found to not only have potent anti-cancer properties per se but also have the ability to promote the immune response in a subject and can thus act as adjuvants for T-cell activation in cancer therapy.

Disclosed herein are caged haptens and caged hapten-antibody conjugates useful for facilitating the detection of targets located proximally to each other in a sample.

Disclosed herein are caged haptens and caged hapten-antibody conjugates useful for facilitating the detection of targets located proximally to each other in a sample.

Chemical entities that are novel compounds, pharmaceutical compositions and methods of treatment of cancer are described.

Chemical entities that are novel compounds, pharmaceutical compositions and methods of treatment of cancer are described.

Chemical entities that are novel compounds, pharmaceutical compositions and methods of treatment of cancer are described.

The present invention provides the preparation processes for several crystal forms of the compound 17beta-Neriifolin (17bNF) and use thereof in anti-tumor applications. The present invention provides preparation processes for four kinds of non-solvated crystal forms, amorphous powders and eleven kinds of solvated crystalline solids, including ethanol-solvated ones, of 17bNF that are not present in nature, and the identification and characterization of these crystal forms by crystallographic research methods such as X-ray powder diffraction. In addition, through vivo anti-tumor experiments with five of the crystal forms in nude mice, we provide anti-tumor and anti-cancer applications of the crystal forms of 17bNF.

Chemical entities that are novel compounds, pharmaceutical compositions and methods of treatment of cancer are described.

Chemical entities that are novel compounds, pharmaceutical compositions and methods of treatment of cancer are described.

Chemical entities that are novel compounds, pharmaceutical compositions and methods of treatment of cancer are described.