Disclosed is a magnetic dendrimer compound and a method for preparing the magnetic dendrimer compound, the molecular formula of which is shown in formula (I): Γ(CH.sub.2).sub.3N.sub.(2.sup.n+1.sub.−1)R.sup.1.sub.(2.sup.n+2.sub.−2)R.sup.2.sub.(2.sup.n+1.sub.)(I). In this formula, Γ indicates magnetic particles coated with SiO.sub.2 on a surface thereof, the magnetic particles having been modified by a silane coupling agent; (CH.sub.2).sub.3N.sub.(2.sup.n+1.sub.−1)R.sup.1.sub.(2.sup.n+2.sub.−2) is a dendritic group, and R.sup.2.sub.(2.sup.n+1.sub.) is a lipophilic group, with 0≤n≤100. Further disclosed is a lubricant comprising the magnetic dendrimer compound.

Disclosed is a magnetic dendrimer compound and a method for preparing the magnetic dendrimer compound, the molecular formula of which is shown in formula (I): Γ(CH.sub.2).sub.3N.sub.(2.sup.n+1.sub.−1)R.sup.1.sub.(2.sup.n+2.sub.−2)R.sup.2.sub.(2.sup.n+1.sub.)(I). In this formula, Γ indicates magnetic particles coated with SiO.sub.2 on a surface thereof, the magnetic particles having been modified by a silane coupling agent; (CH.sub.2).sub.3N.sub.(2.sup.n+1.sub.−1)R.sup.1.sub.(2.sup.n+2.sub.−2) is a dendritic group, and R.sup.2.sub.(2.sup.n+1.sub.) is a lipophilic group, with 0≤n≤100. Further disclosed is a lubricant comprising the magnetic dendrimer compound.

A process for the high-yield preparation of p-(R)calix[9-20]arenes.

Nanoparticle-based vaccines, compositions, kits and methods are used for the effective delivery of one or more antigens in vivo for vaccination and antibody (e.g., monoclonal antibody) production, and for the effective delivery of peptides, proteins, siRNA, RNA or DNA to PAPCs or MHC class II positive cells (e.g. tumor cells). Antigens may be, for example, DNA that results in expression of the gene of interest and induction of a robust and specific immune response to the expressed protein in a subject (e.g., mammal). Antigens may also be immunogenic peptides or polypeptides that are processed and presented. In one embodiment, a nanoparticle-based method to deliver antigens in vivo as described herein includes injection of a vaccine composed of a DNA encoding at least one antigen, or at least one antigenic peptide or polypeptide conjugated to a charged dendrimer (e.g., PADRE-derivatized dendrimer) that is also conjugated to a T helper epitope (e.g., PADRE). Negatively-charged plasmids bind naturally to a positively-charged PADRE-dendrimer, while peptide or polypeptide antigens can be chemically linked to the PADRE-dendrimer if they are not negatively-charged. Alternatively, negatively-charged dendrimers may be used. The compositions, kits, vaccines and methods described herein have both prophylactic and treatment applications, i.e., can be used as a prophylactic to prevent onset of a disease or condition in a subject, as well as to treat a subject having a disease or condition. A vaccine as described herein can be used to mount an immune response against any infectious pathogen or cancer.

The invention discloses a three-dimensional cage-like hyperbranched monomer and preparation method and application thereof. The three-dimensional cage-like hyperbranched monomer has the structural formula I: ##STR00001## ##STR00002##
wherein in the structural formula I: X is any one of —O, —S, —NH; y is any integer from 2 to 8; R is —H or —CH.sub.3. The beneficial effect of the technical scheme proposed in the present invention is: by introducing easily polymerizable olefin groups, the carboxyl group and amide group are combined in the three-dimensional cage-like hyperbranched monomer to make the water solubility good, and it can be copolymerized with many other monomers to obtain the three-dimensional cage-like hyperbranched polymer; when used as an additive for wellbore working fluids, due to the hyperbranched structure of the polymer, it has good salt and temperature resistance, and also has viscosity increasing, filtration loss, and flocculation properties; meanwhile, the synthesis method is simple and the cost is low.

One-pot synthetic methods are disclosed for synthesizing curable, antimicrobial silsesquioxane-silica hybrids by hydrolytically co-condensing a tetraalkoxysilane with two different trialkoxysilanes. Particles are also disclosed that are substantially spherical and have an ordered lamellar internal structure. In addition, polymers prepared front the curable, antimicrobial silsesquioxane-silica hybrids and co-monomers are disclosed.

The present disclosure relates to branched polymers and polyplexes which find use in gene therapy applications as safe and non-toxic nucleic acid transfection agents.

The present invention provides a polyrotaxane of high compatibility with silicones, such as silicone oil, a highly insulative polyrotaxane, and/or a material comprising said polyrotaxane. The present invention provides a polyrotaxane obtained by disposing blocking groups at both ends of a pseudopolyrotaxane, in which the opening in a cyclic molecule is clathrated in a skewered manner by a straight-chain molecule, so that the cyclic molecule does not escape, wherein the cyclic molecule comprises a first group represented by formula I (in formula I, X is a single bond or NH; n is 0 or 1; R is a straight-chain, branched, or cyclic alkyl group, alkenyl group, or alkynyl group comprising 12-20 carbon atoms, with some of the hydrogen in the alkyl group, alkenyl group, or alkynyl group being optionally substituted by an OH group, a CN group, or an NH.sub.2 group; and * is the position of the bond to the cyclic molecule).

##STR00001##

Provided herein are organic solvent-based processes for the removal of rubber from non-Hevea plants such as guayule shrubs. By the use of the processes, solid purified rubber can be obtained that contains 0.05-0.5 weight % dirt, 0.2-1.5 weight % ash, and 0.1-4 weight % resin (when it has been dried so as to contain 0.8 weight % volatile matter).

Provided herein are organic solvent-based processes for the removal of rubber from non-Hevea plants such as guayule shrubs. By the use of the processes, solid purified rubber can be obtained that contains 0.05-0.5 weight % dirt, 0.2-1.5 weight % ash, and 0.1-4 weight % resin (when it has been dried so as to contain 0.8 weight % volatile matter).