The present invention is directed towards natural colorants comprising a material selected from the group consisting of genipin, purified genipin, pre-genipin compounds, iridoid compounds, genipin deriviatives, a genipin-containing substance, and combinations of any thereof; and a primary amine containing compound. Processes of making natural colorants are further disclosed. Additionally, processes of producing a desired color of natural colorants are disclosed.

Solid lipid nanoparticles (SLNs) and suspensions thereof in an aqueous phase are provided, in which the SLNs have high content of oil-soluble pigment and high stability. A food product, such as a beverage, comprising said SLNs is also provided.

An object of the present invention is to provide a method for removing geniposide or genipin or both from a material containing geniposide or genipin or both. The present invention is a method for removing geniposide or genipin or both from a material containing geniposide or genipin or both, the method comprising treating the material containing geniposide or genipin or both using an activated carbon having (a) a methylene blue adsorption ability of 50 ml/g or more; and (b) an iodine adsorption ability of 750 mg/g or more, thereby removing geniposide or genipin or both.

An object of the present invention is to provide a method for removing geniposide or genipin or both from a material containing geniposide or genipin or both. The present invention is a method for removing geniposide or genipin or both from a material containing geniposide or genipin or both, the method comprising treating the material containing geniposide or genipin or both using an activated carbon having (a) a methylene blue adsorption ability of 50 ml/g or more; and (b) an iodine adsorption ability of 750 mg/g or more, thereby removing geniposide or genipin or both.

Here are described SkQ compounds containing cations of various types: alkyl(triphenyl)phosphonium cation, quaternary ammonium cations, including pH-dependent and permanent cations of rhodamines, berberine and palmatine alkaloids.

A carrot concentrate having a. between 0.115 and 0.25 wt. % Carotenoid (relative to the total weight of the carrot concentrate); b. between 7-24 wt. % edible oil (relative to the total weight of the carrot concentrate); c. between 20 and 75 wt. % (DM) of sugars (relative to the dry matter of the carrot concentrate); wherein the dry matter content of the carrot concentrate ranges between 40 and 75 wt. % relative to the total of the concentrate, wherein the wt. % (DM) means the wt. % of the component relative to the dry matter content, wherein the ratio of edible oil to carotenoids ranges between 40 and 210, and wherein the carrot concentrate has a color diluted in yoghurt, at dosage equivalent to a carotenoid concentration of 0.3795 mg/100 g, wherein the color is defined in the CIELAB color space, and wherein the color is described by a L*-value ranging between 93 and 98, an a*-value ranging between −2.5 and +1.0, and a b*-value ranging between 21.5 and 30. A process for making the carrot concentrate and food products containing the carrot concentrate.

The present invention relates to a method to synthesize with high yield a colored metal complex of β-diketones and/or polyphenols by mechanochemistry without using aqueous or organic solvents and covers new complexes obtained therefrom. In an embodiment, only the reactants, a metal alkoxide and a β-diketone and/or a polyphenol, are present and react at different molar ratios to form a metal complex in the form of a homogeneous colored material (i.e. powder) with high yield. If curcumin is used, the color of the final metal complex dye depends on several factors such as the curcuminoids, the metal, the type of alkoxide used, the stoichiometric molar ratio of both reactants and the additives used. If titanium alkoxide and any additive is used, a red or violet colored titanium curcumin complex in powder form is produced. The production process of the metal complex in powder form is characterized by facility of scale up. The entire product is ready to be used in several applications. If polyphenols such as ferulic acid, quercetin, ellagic acid or lignin are used instead of curcumin, other colored complexes are obtained using mechanochemistry. In addition, the product comprising metal complexes of β-diketones and/or polyphenols is characterized by green chemistry manufacture. Besides, these metal complexes of β-diketones and/or polyphenols in several formulations are characterized by improved stability under storage conditions and improved sun protection against UV rays for human skin and human hair. The product is ready to be used alone or in combination with other additives or active ingredients in different formulations. The invention also covers the use of these metal β-diketones/polyphenol complexes in food, cosmetics, the pharmaceutical field and in the creativity field, as sunscreen, skin and hair concealer or foundation in powder form or cream, keratinous dye, textile dye, food dye, dye emulsions, miniemulsions, polymer colloids and catalysts.

The production process of these novel metal-complex dyes is also characterized by rapid production of colored compounds without using solvents and, thus, ecofriendliness. The process of the production of metal β-diketone and/or polyphenol complexes is characterized by the non-formation of toxic by-products and high yield.

In addition, the present invention comprises a hair dyeing molecule or formulation and procedure combining excellent dyeing properties with reduced risk of development cancer or allergies, while being ecological and of the natural origin.

The present invention relates to a method to synthesize with high yield a colored metal complex of β-diketones and/or polyphenols by mechanochemistry without using aqueous or organic solvents and covers new complexes obtained therefrom. In an embodiment, only the reactants, a metal alkoxide and a β-diketone and/or a polyphenol, are present and react at different molar ratios to form a metal complex in the form of a homogeneous colored material (i.e. powder) with high yield. If curcumin is used, the color of the final metal complex dye depends on several factors such as the curcuminoids, the metal, the type of alkoxide used, the stoichiometric molar ratio of both reactants and the additives used. If titanium alkoxide and any additive is used, a red or violet colored titanium curcumin complex in powder form is produced. The production process of the metal complex in powder form is characterized by facility of scale up. The entire product is ready to be used in several applications. If polyphenols such as ferulic acid, quercetin, ellagic acid or lignin are used instead of curcumin, other colored complexes are obtained using mechanochemistry. In addition, the product comprising metal complexes of β-diketones and/or polyphenols is characterized by green chemistry manufacture. Besides, these metal complexes of β-diketones and/or polyphenols in several formulations are characterized by improved stability under storage conditions and improved sun protection against UV rays for human skin and human hair. The product is ready to be used alone or in combination with other additives or active ingredients in different formulations. The invention also covers the use of these metal β-diketones/polyphenol complexes in food, cosmetics, the pharmaceutical field and in the creativity field, as sunscreen, skin and hair concealer or foundation in powder form or cream, keratinous dye, textile dye, food dye, dye emulsions, miniemulsions, polymer colloids and catalysts.

The production process of these novel metal-complex dyes is also characterized by rapid production of colored compounds without using solvents and, thus, ecofriendliness. The process of the production of metal β-diketone and/or polyphenol complexes is characterized by the non-formation of toxic by-products and high yield.

In addition, the present invention comprises a hair dyeing molecule or formulation and procedure combining excellent dyeing properties with reduced risk of development cancer or allergies, while being ecological and of the natural origin.

The invention provides compounds, methods, pharmaceutical compositions, and kits for the treatment of proliferative disorders such as cancer. In one aspect, the methods comprise compounds that inhibit the activity of protein kinases, such as cell division cycle (Cdc) kinase. In another aspect, the methods comprise compounds that inhibit Cdc7 and/or Dbf4 activity. In another aspect, the methods comprise compounds that exhibit anti-proliferative properties useful in treating diseases such as cancer. Compounds useful for any of the methods include compounds of the Formula (A) or (B): ##STR00001##
or pharmaceutically acceptable salts thereof. Exemplary compounds of Formula (A) or (B) include granaticin A, granaticin B, dihydrogranaticin A, dihydrogranaticin B, medermycin, and actinorhodin.

The invention provides compounds, methods, pharmaceutical compositions, and kits for the treatment of proliferative disorders such as cancer. In one aspect, the methods comprise compounds that inhibit the activity of protein kinases, such as cell division cycle (Cdc) kinase. In another aspect, the methods comprise compounds that inhibit Cdc7 and/or Dbf4 activity. In another aspect, the methods comprise compounds that exhibit anti-proliferative properties useful in treating diseases such as cancer. Compounds useful for any of the methods include compounds of the Formula (A) or (B): ##STR00001##
or pharmaceutically acceptable salts thereof. Exemplary compounds of Formula (A) or (B) include granaticin A, granaticin B, dihydrogranaticin A, dihydrogranaticin B, medermycin, and actinorhodin.