The present disclosure relates to a novel fluorogenic dimer compound, useful as a probe for detection of endogenous receptors, in particular G protein-coupled receptors. The present invention provides compositions and kits comprising such compound and methods of labeling a biomolecule, comprising the step of contacting the biomolecule with the compound of the invention.

This invention relates to a compound for labeling mitochondria and a method of producing the same, wherein the compound is represented by Chemical Formula 1 or Chemical Formula 2 below, and is useful in labeling mitochondria.

##STR00001##

In Chemical Formulas 1 and 2, n is 4 or 10.

The present disclosure provides fluorogenic compounds useful for preparing fluorescent calcium ion indicators, the fluorescent indicators themselves, and the use of the fluorescent indicators in methods of detection, discrimination and quantification of metal ions. The subject fluorogenic compounds and fluorescent ion indicators can include a chelating group based on a 2-aminophenoxyethylene glycol 2-aminoethyl ether, N,N,N′,N′-tetraacetic acid (PEGTA) moiety or precursor thereof where the phenyl group of the PEGTA is substituted with or fused with a fluorophore moiety of interest. The subject methods find use in the detection of intracellular calcium ions. Also provided are kits for use in practicing the subject methods.

Provided is an alkoxysilyl group-containing organic EL dye that can be used for the production of fluorescent silica particles that do not fade. This alkoxysilyl group-containing organic EL dye is represented by the general formula X—Y-Q-Z—Si(R.sub.1).sub.n(OR.sub.2).sub.3-n, wherein X is an organic EL dye, Y is a direct bond or —(CH.sub.2).sub.p— (p represents an integer from 1 to 10) or —(O—CH.sub.2CH.sub.2).sub.q— (q represents an integer from 1 to 10), Q is a bond selected from the group consisting of amide bond, ether bond, thioether bond, thioester bond, thiourea bond, disulfide bond, and polyoxyethylene bond, Z is —(CH.sub.2).sub.3— or —(CH.sub.2).sub.2NH(CH.sub.2).sub.3—, R.sub.1 and R.sub.2 represent an alkyl group having 1 to 7 carbon atoms, and n represents 0 or 1.

A dye-sensitized solar cell including a working electrode having a photocatalytic film, a counter electrode, and an electrolyte-containing layer or solid charge-transfer layer containing a basic compound, wherein the photocatalytic film includes an oxide semiconductor layer containing a dye compound represented by the following formula (1), ##STR00001## wherein Y is an optionally substituted hydrocarbon group having 1 to 20 carbon atoms and having —CO—NR.sup.4— or —SO.sub.2—NR.sup.4— in the group, or a direct bond, Z is a conjugated group, R.sup.1, R.sup.2, and R.sup.3 each represent an optionally substituted hydrocarbon group or an optionally substituted hydrocarbonoxy group, at least one of R.sup.1, R.sup.2, and R.sup.3 is an optionally substituted hydrocarbonoxy group, and R.sup.4 represents a hydrogen atom or an optionally substituted hydrocarbon group having 1 to 20 carbon atoms.

The invention relates to specific phenanthrenes, the use of the compound in an electronic device, and an electronic device containing at least one of said compounds. The invention further relates to a method for producing the compound and a formulation and composition containing one or more of the compounds.

The present invention relates to fluorescent dyes. The present invention provides a wide range of fluorescent dyes and kits containing the same, which are applicable for labeling a variety of biomolecules, cells and microorganisms. In one aspect, the invention provides a compound having a maximal fluorescence excitation wavelength, wherein the compound has a structure of Formula II: ##STR00001##
wherein Z.sup.− is a counterion, Y is a bridge unit permitting electron delocalization between F and Ψ, and F is a moiety having the structure: ##STR00002## The present invention also provides various methods of using the fluorescent dyes for research and development, forensic identification, environmental studies, diagnosis, prognosis, and/or treatment of disease conditions.

The present invention relates to fluorescent dyes. The present invention provides a wide range of fluorescent dyes and kits containing the same, which are applicable for labeling a variety of biomolecules, cells and microorganisms. In one aspect, the invention provides a compound having a maximal fluorescence excitation wavelength, wherein the compound has a structure of Formula II: ##STR00001##
wherein Z.sup.− is a counterion, Y is a bridge unit permitting electron delocalization between F and Ψ, and F is a moiety having the structure: ##STR00002## The present invention also provides various methods of using the fluorescent dyes for research and development, forensic identification, environmental studies, diagnosis, prognosis, and/or treatment of disease conditions.

Provided is a compound represented by formula (I), which can be used as a fluorescent probe that becomes highly fluorescent only in an intracellular acidic environment and can be adapted to the fluorescent imaging of an intracellular vesicle that is a microstructure. ##STR00001## In the formula, R.sub.1 and R.sub.2 independently represent a hydrogen atom, or an alkyl group which may be substituted (wherein R.sub.1 and/or R.sub.2 represents an alkyl group which may be substituted); R.sub.3, R.sub.4, R.sub.5, R.sub.6, R.sub.7 and R.sub.8 independently represent a hydrogen atom, a halogen atom, or the like; X represents a functional group to which a labeling site or a target-accumulating site can be introduced, or the like; Y represents a halogen atom, an alkyl group which may be substituted, or the like; m represents an integer of 0 to 5; and n represents an integer of 0 to 5.

Provided is a compound represented by formula (I), which can be used as a fluorescent probe that becomes highly fluorescent only in an intracellular acidic environment and can be adapted to the fluorescent imaging of an intracellular vesicle that is a microstructure. ##STR00001## In the formula, R.sub.1 and R.sub.2 independently represent a hydrogen atom, or an alkyl group which may be substituted (wherein R.sub.1 and/or R.sub.2 represents an alkyl group which may be substituted); R.sub.3, R.sub.4, R.sub.5, R.sub.6, R.sub.7 and R.sub.8 independently represent a hydrogen atom, a halogen atom, or the like; X represents a functional group to which a labeling site or a target-accumulating site can be introduced, or the like; Y represents a halogen atom, an alkyl group which may be substituted, or the like; m represents an integer of 0 to 5; and n represents an integer of 0 to 5.