A structure used for animal cells is provided which includes an elastic body layer having a flat surface on which animal cells are left. The elastic body layer has a surface whose elasticity is changed by partially supporting the elastic body layer from the rear side or by changing a thickness of the elastic body layer.

The presently disclosed subject matter provides a biomimetic organ model, and methods of its production and use. In one exemplary embodiment, the biomimetic organ model can be a multi-layer model including a at least two microchannels and at least one chamber slab with at least one membrane coated with cells disposed between at least one microchannel and the at least one chamber slab. In another exemplary embodiment, the biomimetic organ disease model can be a five-layer model including a first and second microchannel with a membrane-gel layer-membrane coated or encompassing cells disposed between the microchannels. In certain embodiments, at least one device can be coupled to the biomimetic organ model that delivers an agent to at least one microchannel.

The disclosure relates to a glycoconjugate vaccine conferring protection against Francisella tularensis infections and a method to manufacture a glycoconjugate antigen.

The invention relates to a container, in particular a fermenter for a biogas plant, wherein in the container a mixer is arranged that can be removed through an inspection opening provided in a container wall. A boom is provided for this purpose. Furthermore, the invention relates to a related method and a related use.

Probe holder for a bioreactor or other container or vessel, functioning as a base platform or stand to hold a sensor or probe, such as a Raman probe, in its an open position to be sterilized as part of an assembly including the sensor attached to a housing or container with an aseptic connector. The holder aids the user in positioning the sensor or probe at least partially within or in fluid communication with the interior of the bioreactor or vessel and holding and/or locking it in position during the use of the sensor or probe.

The present disclosure relates to apparatuses, systems and methods for culturing cells. In particular, devices and methods are provided for generation and culture of 3d cell aggregates.

The subject invention provides systems and apparatuses for producing microbe-based compositions that can be used in the oil and gas industry, environmental cleanup, as well as for other applications. More specifically, the present invention includes biological reactors, equipment, and materials for fermenting microbe-based compositions.

A rupture disk includes a body including an internal wall extending from a first end of the body to a second end of the body. The internal wall defines an opening extending through the body. In some embodiments, the body further includes an internal flange formed on the internal wall, and the internal flange has a stepped surface. A rupture membrane is positioned within the body, and secured, for example, by cold welding. The rupture membrane may be secured to the stepped surface. The rupture membrane is positioned within the body such that the rupture membrane does not extend beyond the first end of the body. A process system including the rupture disk is also provided. A method of maintaining a process system that includes the rupture disk is also provided.

A diagnostic method for a detection of a nuclear deformation based a cellular differentiation includes the following steps: preparing nano/micropatterned surfaces; performing a cell seeding on the nano/micropatterned surfaces; imaging; analyzing nuclear deformations of a single cell and a cell population with an algorithm method.

Methods, apparatus, and system for a compost system to reduce operator time, reduce power utilization, increase intensity of land use by the compost system, increase efficiency of biological activity in bulk material composted by the compost system, reduce odor production by the compost system, and to reuse water applied to and which may leach out of bulk material. The compost system may comprise an aerated pad, a pivot arm attached to a center of the aerated pad, and a control module. The aerated pad may receive a bulk material to be composted into a compost product. The aerated pad may comprise an air nozzle and a drain to direct water from the bulk material to a water collection system. The pivot arm may deposit the bulk material on the aerated pad. The control module may manage a temperature inside the bulk material using the air nozzle.