The present invention relates to disposable bioreactors having at least one permanently integrated disposable ATR element. These bioreactors are suitable for cultivating microorganisms or cell cultures, or for cell-free gene expression, wherein liquid samples are examined in the bioreactor by means of infrared spectroscopy.

In an aeration method for an isolator system, an incubator is connected to an isolator through a chamber. After closing a door at each sidewall of the chamber, a decontaminating gas is supplied to the chamber through gas supply passages to decontaminate the inside thereof. Next, air is supplied into the chamber through the gas supply passages and an initial aeration is carried out by discharging the decontamination gas through a gas discharge passage. Then, after a door between the isolator and the chamber is opened, and blowers are stopped, gas at a positive pressure in the isolator is introduced into the chamber. The decontaminating gas in the chamber is rapidly discharged to an outside through the gas supply passages and the gas discharge passage, and aeration in the chamber is completed. The time required for aeration of the chamber can be drastically reduced as compared with conventional aeration processes.

Systems and apparatuses for producing microbe-based compositions that can be used in the oil and gas industry, environmental cleanup, as well as for other applications are provided. More specifically, apparatuses comprising two vessels for use in large-scale production of sophorolipids are provided. An apparatus can include a fermentation vessel and a collector vessel connected directly to the fermentation vessel.

A device for storing, incubating or manipulating biological samples, in particular incubating device or shaking device, comprising a sample chamber, an irradiation chamber, and a holder with a UV light source, wherein a sidewall of the irradiation chamber comprises a first mounting member and wherein the holder comprises a second mounting member configured to interact with the first mounting member for pre-mounting the holder to the sidewall.

The present disclosure is directed to systems and methods for sampling and/or controlling the productivity of a bioreactor. The system and methods can include a vessel capable of providing an environment suitable for containing whole broth that can produce the bioproduct, wherein the whole broth contains media and at least one undissolved species, an automated sampling system, a first analytical instrument, and a control system.

A pressurized appliance comprising, a tank, suitable for receiving liquid contents, a cover, suitable for sealing the tank in a closed position, said cover comprising a sampling tip, said tip comprising a cannula capable of being in contact with the contents when the cover is in the closed position, the sampling tip comprising at least one sealable orifice making it possible, when the cover is in its closed position and said orifice is a through-orifice, to ensure a pressure equilibrium between the inside of the cannula and the inside of the tank, and when the cover is in its closed position and said orifice is sealed, to sample the contents via the cannula.

A microalgae culture broth producing system includes a device for culture broth sterilization using a micro bubble generator, an air compression and pressure equalization device for the injection of carbon dioxide and oxygen in the atmosphere into the culture broth. The system also includes an air chilling device to maintain suitable culture broth temperature when water temperature is too high, an automatic carbon dioxide supply device to promote photosynthesis, and a sealed vertical photobioreactor to block out pollutants and increase dissolved carbon dioxide and oxygen concentration. The system further includes a high-efficiency harvesting device using hollow fiber membranes, and a hot air drying device using the waste heat generated by air compression.

A handheld dispensing device has a first dispensing element configured to dispense a structural material and a second dispensing element configured to dispense a biological material. The second dispensing element is single-use and sterilizable. The first dispensing element is connectable to the second dispensing element. A dispensing system also is provided and has a sterilizable chamber; at least one robotic arm assembly and a dispensing device within the sterilizable chamber. The at least one robotic assembly is configured to move the dispensing device that has a first dispensing element and a second dispensing element. The first dispensing element is releasably connectable to the second dispensing element. An external control is device connected to the robotic arm assembly and controls the at least one robotic arm assembly. The first dispensing element dispenses a structural material and the second dispensing element dispenses a biological material.

A dispensing system has a sterilizable chamber. At least one robotic arm assembly and a dispensing device are within the sterilizable chamber. The dispensing device comprising a first dispensing element and a second dispensing element. The first dispensing element is connectable to the second dispensing element The at least one robotic assembly is configured to move the dispensing device. An external control device is connected to the at least one robotic arm assembly and is configured to control the at least one robotic arm assembly. The first dispensing element is configured to dispense a structural material and the second dispensing element is configured to dispense a biological material.

This accommodation device is for performing sterilization through irradiation with ultraviolet light. The device is provided with an ultraviolet light lamp for emitting ultraviolet light, electric wires for supplying power to the ultraviolet light lamp, socket parts for supporting the ultraviolet light lamp, and a housing in which the ultraviolet light lamp is disposed, wherein: the socket parts have formed therein first opening portions which are open to the inside of the housing, and second opening portions which are in fluid connection with the first opening portions and through which the electric wires pass; and the housing has formed therein third opening portions which guide the electric wires to the outside and which are in fluid connection with the second opening portions.