To continue a series of cell treatments even in a case where a treatment has become impossible in any isolator, a cell treatment system is provided with at least two isolators that perform different treatments, such that a sequential series of cell treatments is performed in each of the isolators. The cell treatment system is provided with a first isolator that performs a first treatment, a second isolator that performs a second treatment different from the first treatment, and a common isolator capable of performing the first treatment and the second treatment.

A bioreactor is provided that includes a container for receiving fluid media that contain biological material and a passage with a passage opening between an interior of the container and an exterior of the container. The bioreactor includes a holder configured to hold a sensor that extends at least partially in the passage opening of the passage. The holder has a sensor chamber and a fine-pored glass layer with a pore size of up to 0.2 m. The fine-pored glass layer bounds the sensor chamber at least partially, whereby, in particular, an exchange of fluids between the interior of the container for receiving fluid media that contain biological material and the interior of the sensor chamber is made possible.

Described herein is a filtered, reusable, autoclavable cell culture sample container that would enclose a cell culture growth container such as a flask, Petri dish or well plate and it would be stored in an incubator with or without adjacent samples and sample containers. The purpose of the product is to provide a sterile incubation environment with free-flowing gas exchange with the surrounding environment.

Automated systems and methods for low-pH viral inactivation include adding an elution pool to a first vessel with an acid. Once first vessel pH probes measure sufficiently low pH, the pool is transferred to a second vessel, where the pH is checked again, and the pool is held for a time sufficient to reduce virus concentration to a safe level, and neutralized, filtered, and transferred to a third vessel. Meanwhile, the first vessel is filled with a known-pH buffer, which is checked against readings from first vessel pH probes to determine whether recalibration is needed. After the pool is transferred to the third vessel, the second vessel is filled with a knownpH buffer, which is checked against readings from second vessel pH probes to determine whether recalibration is needed. The process repeats when the known-pH buffer is dumped and a new elution pool is added to the first vessel.

Provided are such features as a cell culturing method capable of continuously culturing cells. A workroom (40) includes an ion generator (47) supplying positive and negative ions into a work space (48).

An assembly includes a single-use sterilizable bag for containing a biological material. The single-use sterilizable bag has at least one insertion opening; and at least one insertable component configured to be inserted into the single-use sterilizable bag via the at least one insertion opening. The at least one insertable component includes a positioning unit for positioning the insertable component with respect to the single-use sterilizable bag and at least one of a processing unit and a sensing unit for handling the biological material.

A campus for fabricating at least one pharmaceutical product has one or more customizable facilities each configured to manufacture the at least one pharmaceutical product, a media/buffer plant, and a utility building connected by a utility line to the media/buffer plant and/or the one or more customizable facilities to provide at least one first utility to the media/buffer plant and/or the one or more customizable facilities via the utility line.

A sterile sampling apparatus includes a first to seventh flow paths, a sampling section, a first and second pumps, and a first to sixth opening/closing mechanism. The sampling section is disposed in the seventh flow path. The first pump is disposed in the sixth flow path. The second pump is disposed in the seventh flow path. The second flow path includes a first opening/closing mechanism. The third flow path includes a second opening/closing mechanism. The fourth flow path includes a third opening/closing mechanism. The first flow path includes a fourth opening/closing mechanism. The sixth flow path includes a fifth opening/closing mechanism. The seventh flow path includes a sixth opening/closing mechanism. The rate of the second pump is higher than that of the first pump.

A system for irradiating a microplate may include a modular light engine with one or more light emitting devices. The light emitting devices are configured to emit germicidal radiation to irradiate the microplate, which is configured to be positioned below the modular light engine inside a chamber of the microplate irradiation system. In this way, a uniform intensity of germicidal radiation may be output by light emitting devices, resulting in disruption of contaminating nucleic acids present in the microplate.

The present invention involves a reinforced tubing structure that is particularly useful for reinforcing tubing that is present inside disposable bioreactor bags, including for example thermowell tubing.