A method and system of and for handling, preserving, separating, filtering, collecting, manipulating, and/or culturing ex vivo biological material including red blood cells, white blood cells, and blood plasma within a bioreactor having a gas permeable membrane that allows for passive ventilation.

A holder for holding one or more biological indicators and/or one or indicators and one or more thermocouples. The holder includes one or more basic parts, being at least one first basic part where one or more biological indicators and/or one or more thermocouples can be placed in the basic part. The basic part is provided at the location where the biological indicator or indicators can be located with one or more holes. The holder is provided with means for securing the one or more thermocouples and/or biological indicators in the holder. At least one of the one or more basic parts is flexible.

The present application is directed to a sampling system for sampling a fluid from a vessel, where the sampling system includes a sterile dispenser assembly operatively connected to the vessel, the sterile dispenser assembly including a valve operatively connected to the vessel, a membrane, and a needle, and a detachable sterile sampling container assembly operatively connected to the sterile dispenser assembly, the detachable sterile sampling container assembly including a sampling container, a membrane attached to the sampling container, and a sampling container housing enclosing the sampling container, where the sampling container housing includes a compressible portion having a deflated configuration and an expanded configuration.

The present invention provides apparatus and methods for production of tissue structures, organs, vaccines, and antibody products. In some examples, a cleanspace facility may be equipped with fluid interconnections and controls. The fluid interconnections may be located in a primary cleanspace or peripheral to a primary cleanspace. Sterilization may be performed within the primary cleanspace and within the fluid interconnections. In some examples, the facility may include modelling hardware and software, nanotechnology and microelectronic apparatus, and additive manufacturing equipment to print cells and support matrix to allow cells to grow into tissue structures and organs. Novel structures combining various cell types and electronics may be formed with the fabricator. In some examples, advanced vaccine products may be produced entirely within the scalable, sterile, and automated fabricator.

A pass box configured to accommodate and decontaminate an article by concentrating a mist of decontamination agent on an article's surface and to reduce a duration of aeration operations. The box includes a decontamination chamber, an aeration chamber in which residue of the decontamination agent is removed from the article's surface, a decontamination agent supply device, a decontamination agent control device, a moving device configured to reposition the article, and an air supply and exhaust device. The decontamination agent supply device converts a chemical into the mist and supplies it into the decontamination chamber. The decontamination agent control device includes vibration boards that are adjacent to internal wall surfaces of the decontamination chamber and that are ultrasonically vibrated to generate sound flows in the vertical direction thereby pressing the mist with acoustic radiation to concentrate the mist on the external surfaces of the article.

A device for seeding cells includes a container with a wall, a bottom and a lid. The wall extends between the bottom and the lid. The container can be equipped to be loaded with cells, in particular with cells form a cell suspension. The container defines a rotation axis. The device is further equipped to rotate the container around the rotation axis. The container includes a structured surface that can be arranged at the inner surface of the container. The structured surface has structures equipped to receive the cells. The rotation exerts a (g-)force in direction of the structured surface, such that the g-force acts perpendicular to the structured surface. The exerted force in the direction of the structured surface resembles a g-force required for sedimentation of the cells into the structures.

A cell culture vessel comprising a housing in which a culture chamber is provided. In the housing, at least two holes that connect the outside of the housing and a culture chamber are provided.

A safety cabinet includes a work space where work is performed; a front panel disposed in a front surface of the work space; and an air cleaner that cleans air to be supplied to the work space. An imaging device is disposed on one side surface side of side surfaces of the work space, and a connection opening is disposed on the other side surface side facing one side surface.

A container for storing, mixing and/or cultivating a medium, in particular a bioreactor for a medium, comprises a line system as a discharge line, feed line and/or bypass line of the bioreactor. The system can comprise a line body formed as a single piece for a medium to flow therethrough. The has a first and a second connection region for connecting in particular to the container and/or the line system and at least a first and a second coupling apparatus in the region between the connection regions.

The present invention relates to smart tank for a bio-pharma process line, a smart tank assembly, a method for assembling a smart tank and a system comprising multiple smart tanks. The smart tank comprises a top plate element, at least one sidewall element, and a bottom plate element, wherein the top plate element, the at least one sidewall element and the bottom plate element are arranged to form a reservoir for receiving at least one biochemical medium. The smart tank comprises further at least one channel, for guiding the at least one biochemical medium and/or an operating medium. The at least one channel extends within the top plate element and at least one of the at least one sidewall element and/or the bottom plate element.