Patent classifications
C12M43/00
SYSTEM AND METHOD FOR CARBON DIOXIDE REACTOR CONTROL
A system optionally including a carbon oxide reactor. A method for carbon oxide reactor control, optionally including selecting carbon oxide reactor aspects based on a desired output composition, running a carbon oxide reactor under controlled process conditions to produce a desired output composition, and/or altering the process conditions to alter the output composition.
METHOD AND PRODUCT FOR DETECTING EMBRYO HEALTH CONDITION BY USING BLASTOCYST CULTURE SOLUTION
The invention provides a method and a product for detecting the health status of an embryo by using a blastocyst culture medium. Specifically, the present invention provides an in vitro method for detecting the health status of embryos using blastocyst culture medium, characterized in that it comprises the steps of: (a) providing a first blastocyst culture system containing a blastocyst of in vitro culture on Day 5 (D5) to Day 6 (D6); (b) transferring the blastocysts into a second blastocyst culture system containing a fresh blastocyst culture medium, and culturing in the exchanged medium for a time of T1, thereby obtaining a spent blastocyst culture medium; (c) collecting the spent blastocyst culture medium, thereby obtaining a cell-free spent blastocyst culture medium, i.e. a test sample; and (d) performing a genetic assay to identify the health status of the blastocyst. The method can reduce the risk of being Interfered by contaminants from extra sperms and maternal-derived granulosa cells during IVF and ICSI treatment, and can accurately identify the health status of the embryo.
METHODS AND SYSTEMS FOR DETERMINING TARGET SENSITIVITY TO A THERAPEUTIC FORMULA
Systems and methods are disclosed herein for determining the sensitivity of a target to a therapeutic formula. The systems include a measurement device for measuring properties of a target sample fluid housed within a cartridge (the cartridge having at least one test compartment and at least one control compartment). Methods can include determining the concentration of the target suspended in a target sample fluid and placing the target sample fluid into at least one test compartment comprising a first therapeutic formula. The system, via a processor, measures the properties of the sample fluid, compares the measured properties to a threshold property, determines the sensitivity of a target species to a therapeutic formula, and presents an indicator of the target sensitivity to an end user. In some embodiments, the sensitivity data can be stored to a database for later use by an adaptive machine learning tool.
BLOOD CIRCULATION FOR CULTURE GROWTH
Blood being circulated to mimic the environment it naturally inhabits increases growth of cultures including bacteria for analysis. The present disclosure presents examples of a device, method, computer-readable medium, and other techniques for simulating a natural environment for blood. The techniques may include a channel with a hydrophobic interior surface and a fluid mover to encourage continuous fluid flow through the channel. The techniques may further include a gas exchange opening of the channel that exposes a fluid to gas outside of the channel.
Automated cell processing methods, modules, instruments, and systems
In an illustrative embodiment, automated multi-module cell editing instruments are provided to automate multiple edits into nucleic acid sequences inside one or more cells.
AUTOMATED CELL PROCESSING METHODS, MODULES, INSTRUMENTS, AND SYSTEMS
In an illustrative embodiment, automated multi-module cell editing instruments are provided to automate multiple edits into nucleic acid sequences inside one or more cells.
Compositions, methods, modules and instruments for automated nucleic acid-guided nuclease editing in mammalian cells via viral delivery
This invention relates to compositions of matter, methods, modules and instruments for automated mammalian cell growth and mammalian cell transduction followed by nucleic acid-guided nuclease editing in live mammalian cells. The present compositions and methods entail viral delivery of an editing cassette to live mammalian cells such that the editing cassettes edit the cells and the edited cells continue to grow, preferably using a fully-automated end-to-end instrument to process the cells without human intervention to enhance cell processing uniformity and to maintain the integrity of the cell culture.
HYDROGEN FLOW AND RATIO CONTROL USING ELECTROLYZER STACK CURRENT
Disclosed herein are methods, devices and systems to control hydrogen flow and ratios by using electrolyzer stack current to control to gas flowrate and ratio control through using only an electrolyzer stack current to control the H.sub.2 mass flow rate to downstream processes requiring precise ratio control of the H.sub.2 input gas with other process inputs, like CO.sub.2, for example. In an embodiment, the systems disclosed herein deliver a precise ratio control to maintain a stable reaction and minimize excess H.sub.2 and CO.sub.2 in the product
COMPOSITIONS, METHODS, MODULES AND INSTRUMENTS FOR AUTOMATED NUCLEIC ACID-GUIDED NUCLEASE EDITING IN MAMMALIAN CELLS VIA VIRAL DELIVERY
This invention relates to compositions of matter, methods, modules and instruments for automated mammalian cell growth and mammalian cell transduction followed by nucleic acid-guided nuclease editing in live mammalian cells.
COMPOSITIONS, METHODS, MODULES AND INSTRUMENTS FOR AUTOMATED NUCLEIC ACID-GUIDED NUCLEASE EDITING IN MAMMALIAN CELLS
This invention relates to compositions of matter, methods, modules and instruments for automated mammalian cell growth, reagent bundle creation and mammalian cell transfection followed by nucleic acid-guided nuclease editing in live mammalian cells.