The present invention provides substantia nigra organoids on silica iSECnMs and method of producing the same. The present invention also provides method of cell therapy including the substantia nigra organoids on silica iSECnMs.

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The purpose of the invention is to provide novel cell culture substrates, cell culture vessels, and methods for cell culture. A cell culture substrate having a planar mesh structure, the substrate being coated with a polymer, is provided. Cells are cultured in a cell culture vessel having this substrate.

A cell adhesive substrate comprising a substratum, on a surface of which a peptide group is immobilized, wherein the peptide group comprises a peptide containing 40% or more and 75% or less of one or two or more of basic amino acid residues selected from the group consisting of lysine, arginine and histidine and 25% or more of one or two or more of hydrophobic amino acid residues selected from the group consisting of leucine, isoleucine, glycine, alanine, valine, phenylalanine, proline, tryptophan and methionine. There is provided a cell adhesive substrate that is unlikely to cause an immune reaction and can maintain a cell adhesion effect for a long time.

A system and method for growing and maintaining biological material including producing a protein associated with the tissue, selecting cells associated with the tissue, expanding the cells, creating at least one tissue bio-ink including the expanded cells, printing the at least one tissue bio-ink in at least one tissue growth medium mixture, growing the tissue from the printed at least one tissue bio-ink, and maintaining viability of the tissue.

The present disclosure relates to products and methods for activating and/or expanding T cells. Certain embodiments of the present disclosure provide a porous scaffold comprising one or more conjugated T cell stimulatory molecules.

Disclosed are bioprinters for rapidly fabricating biological tubes comprising extruding a bio-ink filament onto a rotating mandrel. Also disclosed are methods of rapidly fabricating biological tubes comprising extruding a bio-ink filament onto a rotating mandrel, maturing the deposited bio-ink filament, and removing the biological tube from the mandrel. Also disclosed are methods of fabricating a multilayered biological tube. Also disclosed are engineered biological tubes prepared using the disclosed methods.

Described is a fuel cell comprising an electrode catalyst assembly, and a two-dimensional (2D) amorphous carbon, wherein the 2D amorphous carbon has a crystallinity (C)?0.8.

Methods of culturing and manufacturing of cells on a large-scale level are disclosed. Particularly, a manufacturing system and device, and methods of using the system and device for culturing and manufacturing cells in hollow fibers made from alginate polymers are provided.

An object of the present invention is to provide a method for producing a sheet-like cell structure having excellent strength and shape-maintaining performance, and a sheet-like cell structure having excellent strength and shape-maintaining performance. According to the present invention, there is provided a method for producing a sheet-like cell structure, including: a step of adding a biocompatible macromolecular block, a cell, and a liquid medium onto a culture support body having a plurality of recessed portions on a culture surface, and immersing the biocompatible macromolecular block and the cell in uppermost portions of the recessed portions; and a step of culturing the cell to obtain a sheet-like cell structure.

There is provided an adherent cell-culture support comprising gold nanoparticles on the surface where the cells attach to, wherein the size of the nanoparticles is from 5 nm to 2 microns, the distance between the nanoparticles is from 2 nm to 30 nm and the anisotropy aspect ratio is greater than 1. These substrates have improved properties for allowing the culturing and subsequent detachment of cells, with potential applications in a wide range of fields such as stem cell research and tissue engineering. There is also provided a process for their preparation and several uses thereof.