The microfluidic devices and systems disclosed herein reduce sample loss and help decrease sample processing bottlenecks for applications such as next generation sequencing (NGS). The microfluidic devices include a plurality of reaction modules. Each reaction module may comprise one or more reaction circuits. Each reaction circuit may comprise a single reaction flow channel with each reaction circuit connected by a bridge flow channel. Alternatively, each reaction circuit may comprise two or more reaction flow channels connected by two or more bridge flow channels. The combination of any two bridge flow channels and a portion of the two or more reaction flow channels between the any two bridge flow channels defining may define the reaction circuit. The reaction module may be arranged as nodes connected by bridge flow channels or each reaction module may be arranged in a parallel fashion on the microfluidic device.

An electromagnetic pump (100). The electromagnetic pump (100) comprises a conduit (101) comprising an inlet (103) and an outlet (105). A first magnetic field generating unit (109) is provided for generating a first magnetic field having a first component with a first direction in the conduit. A second magnetic field generating unit (111) is provided for generating a second magnetic field having a second component with a second direction in the conduit (101), the second direction being substantially opposite to the first direction. A piston member (113) is disposed within the conduit, the piston member (113) being moveable within the conduit (101) under the influence of the first and/or second magnetic fields to pump fluid received from the inlet (103) of the conduit (101) to the outlet (105) of the conduit (101).

A pump tray has a liquid pump with an inlet and outlet. A blindly matable liquid coupler fluidicly couples with the pump inlet and a blindly matable liquid coupler fluidicly couples with the pump outlet. A chassis of the pump tray has an alignment member configured to removably engage with another device and to restrict, to a limited number of degrees-of-freedom, movement of the chassis relative to the other device (e.g., a liquid pumping unit). The blindly matable liquid couplers are so physically coupled with the chassis as to inhibit movement of them relative to the chassis. A liquid pumping unit also has a chassis defining a bay configured to receive a pump tray, a liquid inlet coupler and a liquid outlet coupler, and a reservoir fluidicly coupled with the liquid inlet coupler. A blindly-matable liquid coupler fluidicly couples with the reservoir outlet and a blindly-matable liquid coupler fluidicly couples with the liquid outlet coupler. An alignment member is configured to removably engage with the pump tray and to restrict, to a limited number of degrees-of-freedom, movement of the pump tray relative to the chassis of the liquid pumping unit.

A pump tray has a liquid pump with an inlet and outlet. A blindly matable liquid coupler fluidicly couples with the pump inlet and a blindly matable liquid coupler fluidicly couples with the pump outlet. A chassis of the pump tray has an alignment member configured to removably engage with another device and to restrict, to a limited number of degrees-of-freedom, movement of the chassis relative to the other device (e.g., a liquid pumping unit). The blindly matable liquid couplers are so physically coupled with the chassis as to inhibit movement of them relative to the chassis. A liquid pumping unit also has a chassis defining a bay configured to receive a pump tray, a liquid inlet coupler and a liquid outlet coupler, and a reservoir fluidicly coupled with the liquid inlet coupler. A blindly-matable liquid coupler fluidicly couples with the reservoir outlet and a blindly-matable liquid coupler fluidicly couples with the liquid outlet coupler. An alignment member is configured to removably engage with the pump tray and to restrict, to a limited number of degrees-of-freedom, movement of the pump tray relative to the chassis of the liquid pumping unit.

The present invention relates to an electrostatically actuated device comprising at least first chamber, an electrode chamber comprising a deformable electrode. The deformable electrode is disposed in the electrode chamber such as to form a first electrode chamber and a second electrode chamber.

Devices and methods for handling liquids are provided. The devices and methods make use of specifically controlled centrifugal forces to drive liquid flow between two cavities connected by a conduit such that as liquid flows into the second cavity, a gas volume is trapped in the second cavity and a pressure of the gas increases, allowing for pneumatic control of liquid flow. The devices and methods facilitate one or more of the mixing, metering and sequencing of liquids, for example on a microfluidic device.

The present invention discloses a path-type liquid medicine delivery electro-osmosis pump that can be applied to a wearable medicine device. An electro osmosis pump according to the present invention includes: a connector provided with a liquid medicine inlet and a liquid medicine outlet; a check valve assembly combined to one side of the connector; and a driver that is connected to the other side of the connector and moves the liquid medicine toward the liquid medicine outlet by applying pressure to the liquid medicine while being separated from the liquid medicine, which passes through the check valve assembly.

The present invention discloses a path-type liquid medicine delivery electro-osmosis pump that can be applied to a wearable medicine device. An electro osmosis pump according to the present invention includes: a connector provided with a liquid medicine inlet and a liquid medicine outlet; a check valve assembly combined to one side of the connector; and a driver that is connected to the other side of the connector and moves the liquid medicine toward the liquid medicine outlet by applying pressure to the liquid medicine while being separated from the liquid medicine, which passes through the check valve assembly.

A low-force, non-displacement, micro/miniature valve and/or pump assembly is provided. A tube component having a first side port coupled to an inlet portion and a second side port coupled to an outlet portion can be selectively moved to alternatively couple the side ports to a first or second piston pump chamber. First and second pistons can be actuated after positioning the tube component to either draw in fluid or push out fluid from either the first or second piston pump chambers during each actuation of the pistons. The fluid can be drawn in from a reservoir and can be expelled to a patient for providing a dose of the fluid to the patient.

Embodiments of the disclosure provide a micro-fluid pump having a pump cover with a distribution wall, a one-way valve having a spark surface, and a micro-fluid pump including such a one-way valve as well as a micro fluid pump including a diaphragm deformation control structure. The pump having the pump cover with the distribution wall includes a pump body. The pump cover overlies the pump body to form at least a portion of the inlet passage and at least a portion of the discharge passage, and includes an inlet cavity for containing fluid entering the micro-fluid pump from the outside and a discharge cavity for containing fluid to be discharged from the micro-fluid pump, which cavities are separated by an isolation portion. The pump cover has on its bottom surface a distribution wall which is disposed in the inlet cavity and extends at least partially toward the partition portion.