Disclosed is a control system for a pulsation dampener device. The system comprises a fluid reservoir, a pipeline assembly extending between the reservoir and the bladder of the pulsation dampener device, and a bladder sensor for gauging the fluid pressure within the bladder. The system is configured such that, when the pulsation dampener device is not operative and when the pressure of the fluid within the bladder is above or below a predetermined preoperative bladder threshold, the excess or deficient equivalent volume of fluid respectively is transferred from the bladder to the reservoir or from the reservoir to the bladder respectively. Further, when the pulsation dampener device is operative and when at least one pressure reading of the fluid within the bladder is above or below a predetermined operative bladder threshold, the excess or deficient equivalent volume of fluid respectively is transferred from the bladder to the reservoir or from the reservoir to the bladder respectively.