A Heisenberg scaler reduces noise in quantum metrology and includes: a stimulus source that provides physical stimuli; a physical system including quantum sensors that receive a first and second physical stimuli; produces a measured action parameter; receives an perturbation pulse; and produces modal amplitude; an estimation machine that: receives the measured action parameter and produces a zeroth-order value from the measured action parameter; a gradient analyzer that: receives the measured action parameter and produces the measured action parameter and a gradient; the sensor interrogation unit that; receives the modal amplitude; receives the gradient and the measured action parameter produces the perturbation pulse; and produces a first-order value from the modal amplitude, the gradient, and the measured action parameter; a Heisenberg determination machine that: receives the zeroth-order value; receives the first-order value; and produces a physical scalar from the zeroth-order value and the first-order value.

A Heisenberg scaler reduces noise in quantum metrology and includes: a stimulus source that provides physical stimuli; a physical system including quantum sensors that receive a first and second physical stimuli; produces a measured action parameter; receives an perturbation pulse; and produces modal amplitude; an estimation machine that: receives the measured action parameter and produces a zeroth-order value from the measured action parameter; a gradient analyzer that: receives the measured action parameter and produces the measured action parameter and a gradient; the sensor interrogation unit that; receives the modal amplitude; receives the gradient and the measured action parameter produces the perturbation pulse; and produces a first-order value from the modal amplitude, the gradient, and the measured action parameter; a Heisenberg determination machine that: receives the zeroth-order value; receives the first-order value; and produces a physical scalar from the zeroth-order value and the first-order value.

Sensors and methods are provided that include a diamond material containing a nitrogen vacancy center, the diamond material being configured to be exposed to an environment comprising one or more gases, an optical light source configured to excite the nitrogen vacancy center of the diamond material with an optical light beam produced therefrom, a detector configured to detect a signal originating from the diamond material in response to the optical light beam exciting the nitrogen vacancy center, and the capability of analyzing the signal to identify a specific gas in the environment. Also included are levitated spin-optomechanical systems capable of elevating in a vacuum a diamond material containing a nitrogen vacancy center, applying microwave radiation to the diamond material for controlling and flipping the electron spin of the nitrogen vacancy center, and monitoring electron spin of the nitrogen vacancy center.

System and method for detecting the presence at a distance of materials utilizing the atomic structure and characteristics of the elements in the chemicals comprising the material.

The present invention relates to a magnetometer (100) using optically detected magnetic resonance (ODMR), where a solid state material (10), such as diamond, with an ensemble of paramagnetic defects, such as nitrogen vacancies centers NV, is applied. An optical cavity (20) is optically excited by an irradiation laser (25) arranged therefore. A coupling structure (30) causes a microwave excitation () of the paramagnetic defects, and a permanent magnetic field (40, B_C) causes a Zeeman splitting of the energy levels in the paramagnetic defects. A probing volume (PV) in the solid state material is thereby defined by the spatially overlapping volume of the optical excitation by the irradiation laser (25), the coupling structure (30) also exciting the defects, and the constant magnetic field. The magnetometer then measures an unknown magnetic field by detecting emission (27), e.g. fluorescence, from the defects in the probing volume (PV) from the double excitation of the defects by the irradiation laser, and the coupling structure exciting these defects.

Disclosed herein are methods of preparing a composition comprising crystalline biomolecules, for example, crystalline antibodies. In exemplary embodiments, the method comprises forming a fluidized bed of crystalline biomolecules using, for example, a counter-flow centrifuge to exchange buffer and/or to concentrate the crystalline biomolecules in a solution. Also provided are methods of detecting crystalline biomolecules and/or amorphous biomolecules in a sample.

A light-trapping geometry enhances the sensitivity of strain, temperature, and/or electromagnetic field measurements using nitrogen vacancies in bulk diamond, which have exterior dimensions on the order of millimeters. In an example light-trapping geometry, a laser beam enters the bulk diamond, which may be at room temperature, through a facet or notch. The beam propagates along a path inside the bulk diamond that includes many total internal reflections off the diamond's surfaces. The NVs inside the bulk diamonds absorb the beam as it propagates. Photodetectors measure the transmitted beam or fluorescence emitted by the NVs. The resulting transmission or emission spectrum represents the NVs' quantum mechanical states, which in turn vary with temperature, magnetic field strength, electric field strength, strain/pressure, etc.

A method for providing information relevant to the diagnosis of a neurodegenerative disorder. The method includes (i) obtaining a biological sample containing vesicles from a subject, (ii) measuring the level of amyloid beta in the biological sample using an antibody specific for the N-terminus of amyloid beta, and (iii) comparing the measured level of amyloid beta in the biological sample with the level of amyloid beta in a previously prepared control sample.

A method includes applying, to a sample exhibiting optical scattering and having a emission particles distributed therein that exhibit spin-dependent fluorescence, a magnetic field to shift a resonance frequency of each emission particle in a position-dependent manner. The method also includes exciting the sample with an excitation beam that causes at least one emission particle to emit spin-dependent fluorescence and detecting the emitted spin-dependent fluorescence. The method also includes estimating a position of the emission particle(s) within the sample based on the spin-dependent fluorescence, the resonance frequency, and the magnetic field. The method also includes estimating optical transmission information for the sample based on a wavefront of the excitation beam and the estimated position. The optical transmission information including a measure of an optical field at each position of an emission particle.

A microwave moisture sensor for agricultural materials, such as grains and nuts, is disclosed herein that includes a material sample holder having a substantially cylindrical cavity formed therein. The meter assembly further includes a transmitting antenna on a side of the sample holder and a receiving antenna on a side of sample holder directly opposite the transmitting antenna wherein the sample holder is located between the two antennas, the receiving antenna configured to receive a transmitted microwave through the sample holder.