This invention relates to the preparation of N-(phosphonomethyl)glycine (“glyphosate”) from N-(phosphonomethyl)iminodiacetic acid (“PMIDA”), and more particularly to methods for control of the conversion of PMIDA, for the identification of reaction end points relating to PMIDA conversion and the preparation of glyphosate products having controlled PMIDA content. One such method involves obtaining a series of Fourier transform infrared (“FTIR”) analyses of the PMIDA content of the aqueous reaction medium or a sample thereof during the course of the reaction. From a plurality of FTIR analyses, a projection is made of the batch reaction time or continuous oxidation residence time within the oxidation reaction zone at which a target conversion or end point may be anticipated to be attained or is attained.

This invention relates to the preparation of N-(phosphonomethyl)glycine (“glyphosate”) from N-(phosphonomethyl)iminodiacetic acid (“PMIDA”), and more particularly to methods for control of the conversion of PMIDA, for the identification of reaction end points relating to PMIDA conversion and the preparation of glyphosate products having controlled PMIDA content. One such method involves obtaining a series of Fourier transform infrared (“FTIR”) analyses of the PMIDA content of the aqueous reaction medium or a sample thereof during the course of the reaction. From a plurality of FTIR analyses, a projection is made of the batch reaction time or continuous oxidation residence time within the oxidation reaction zone at which a target conversion or end point may be anticipated to be attained or is attained.

The invention relates to a method for prognosing, diagnosing, determining the risk, and monitoring the evolution of a muscular dystrophy. It also relates to a method for evaluating the efficacy of a treatment of a muscular dystrophy in a subject in need thereof.

The present invention relates to methods and compositions for monitoring, diagnosis, prognosis, and determination of treatment regimens in subjects suffering from or suspected of having a renal injury. In particular, the invention relates to using a measured urine concentration of one or more of TIMP2 and IGFBP7 in combination with one or more of a measured serum creatinine and a measured urine output, which results are correlated to the renal status of the subject, and can be used for diagnosis, prognosis, risk stratification, staging, monitoring, categorizing and determination of further diagnosis and treatment regimens in subjects suffering or at risk of suffering from an injury to renal function, reduced renal function, and/or acute renal failure.

The present invention relates to a method of analyzing a polyamine having a plurality of amino groups in the same molecule or a monoamine having an amino group and a phenolic hydroxyl group in the same molecule on the basis of the measurement result of the intensity of excimer fluorescence emitted as a result of the derivatization of the polyamine or the monoamine with a fluorescence derivatization reagent having a pyrene group. The method is characterized in that the fluorescence derivatization reagent comprises 2-chloro-4-methoxy-6-(4-(pyren-1-yl) butoxy)-1, 3, 5-triazine represented by the formula (2). ##STR00001##

The present invention relates to a method of analyzing a polyamine having a plurality of amino groups in the same molecule or a monoamine having an amino group and a phenolic hydroxyl group in the same molecule on the basis of the measurement result of the intensity of excimer fluorescence emitted as a result of the derivatization of the polyamine or the monoamine with a fluorescence derivatization reagent having a pyrene group. The method is characterized in that the fluorescence derivatization reagent comprises 2-chloro-4-methoxy-6-(4-(pyren-1-yl) butoxy)-1, 3, 5-triazine represented by the formula (2). ##STR00001##

An object of the present invention is to reduce error reaction that is not derived from enzyme reaction in a method for measuring histamine using histamine dehydrogenase. The present invention provides a kit for detecting histamine or an electrochemical sensor capable of detecting the oxidation of histamine, comprising (i) histamine dehydrogenase, and (ii-a) boric acid or a salt thereof, and/or a boronic acid or a salt thereof, and/or (ii-b) alkyl sulfate. The present invention also provides a method for detecting histamine using (i) histamine dehydrogenase, and (ii-a) boric acid or a salt thereof, and/or a boronic acid or a salt thereof, or (ii-b) sodium laurel sulfate, or using an electrochemical sensor capable of detecting the oxidation of histamine, comprising these components.

A system and related methods for monitoring and dosing peroxycarboxylic acids, particularly peracetic acid, in food processing applications based upon desired concentration of the processing solution. The concentration of the peroxycarboxylic acid measured and additional peroxycarboxylic acid being added to the processing solution if the measured concentration is below a threshold level of the desired concentration, and additional water being added to the processing solution if the measured concentration is above a threshold level of the desired concentration. The system and related methods capable of being used in utilized with either live stream or static, storage tank based systems, to keep the concentration of peroxycarboxylic acid at or near desired concentration levels while experiencing less variation than experienced with conventional flow-based or hand-mixed systems.

A system and related methods for monitoring and dosing peroxycarboxylic acids, particularly peracetic acid, in food processing applications based upon desired concentration of the processing solution. The concentration of the peroxycarboxylic acid measured and additional peroxycarboxylic acid being added to the processing solution if the measured concentration is below a threshold level of the desired concentration, and additional water being added to the processing solution if the measured concentration is above a threshold level of the desired concentration. The system and related methods capable of being used in utilized with either live stream or static, storage tank based systems, to keep the concentration of peroxycarboxylic acid at or near desired concentration levels while experiencing less variation than experienced with conventional flow-based or hand-mixed systems.

An analysis method having: a sample preparation step of preparing a measurement sample by mixing a measurement object containing pyrroloquinoline quinone or a salt thereof with glycine so that the pyrroloquinoline quinone or the salt thereof reacts with the glycine to produce imidazopyrroloquinoline or a salt thereof; and a quantitative analysis step of determining quantitatively the amount of the pyrroloquinoline quinone and the salt thereof contained in the measurement object, based on a chromatogram of the imidazopyrroloquinoline or the salt thereof contained in the measurement sample obtained by chromatography.