A method is provided that includes rinsing an oral cavity of a subject with a rinse liquid. Thereafter, a gargle liquid is introduced into the oral cavity and gargled by the subject. Thereafter, at least a portion of the gargled liquid is collected as a specimen sample. Other embodiments are also described.

The subject disclosure provides systems, computer-implemented methods, and clinical workflows for meso-dissection of biological specimens and tissue slides by incorporating annotation and inter-marker registration modules within digital pathology imaging and meso-dissection (or milling) systems. Images of a reference slide a milling slide may be acquired using the same imaging system, with the annotations on the image associated with the milling slide being based on the inter-marker registration. Each image along with its respective annotations and meta-data may be associated with a project or a case, and stored in an image management system. A same-marker registration may be used to map annotations from the annotated image of the milling slide to a live image of the milling slide. The milling slide may be milled based on the annotations, with milled tissue output into a contained that is labeled in association with the labeled input slides.

The present invention describes a non-invasive system and method for detecting early stage Alzheimer's and other autoimmune diseases associated with neurological deficits, including Multiple Sclerosis and Parkinson's Disease. By analyzing the volatile organic compounds (VOCs) found in the otic canal either in gaseous form or as what is commonly known as “earwax”, the current invention discloses how these disease signatures/profiles are illustrative of the presence or absence of a particular disease.

The invention relates to a new method of determining the presence, absence, number or position(s) of one or more post-translational modifications in a peptide, polypeptide or protein. The invention uses transmembrane pores.

Portable automated systems and methods can be used to perform field testing of patient blood chemistry to determine whether biological death has occurred in a clinically dead patient, and therefore whether the patient is a viable candidate for resuscitation efforts. A blood sample is received in a detector, which analyzes the blood sample to generate a signal representing at least one blood chemistry parameter of the blood sample and transmits a signal representing the at least one blood chemistry parameter to a processor. The processor compares the at least one blood chemistry parameter to a corresponding at least one resuscitatability parameter and, based on the comparison, causes an indicator to emit a resuscitatability indicator signal indicating potential resuscitatability, such as “resuscitatable”, “non-resuscitatable” or “borderline”/“indeterminate”.

The present invention relates to a novel antibody against HERV-K envelope that targets a conserved region not affected by glycosylation or by native conformation, and its use in diagnostics and/or is therapy.

Systems and methods for generating user-specific recommendations of products or services by collaborative filtering executed and/or performed by one or more trained or untrained predictive models configured to ingest product attribute(s), product purpose(s), user location data, and/or user demographics. The predictive model(s) are leveraged to detect and determine user-specific preferences for, and preferences against, particular attributes, features, ingredients, aesthetic styles, and so on.

A method is provided for evaluating a set of measurement data from an oral glucose tolerance test. The method may include calculating a similarity measure that quantifies the similarity between a time profile of the series of measured data of the glucose concentration and a corresponding glucose reference profile. The method may include calculating a further similarity measure that quantifies the similarity between the profile of the series of measured values of the further analyte concentration and the corresponding analyte sample profile, wherein the data set is represented by a point in a vector space that comprises coordinate axes that are formed by the similarity measures, whereby the coordinates of said point contain the calculated values of the similarity measures. The method also may include evaluating the position of the point with respect to reference points, which each represent a defined state of health, in order to calculate a parameter that specifies the state of the glucose metabolism of the patient.

The present invention relates to a stable method for introducing at least one inducible cassette into a cell, and permitting controllable transcription from within that inducible cassette. The method may be used for any cell type, from any eukaryotic organism, but has a particular application in the introduction of inducible cassettes into pluripotent stem cells, such as animal or human pluripotent stem cells (hPSCs). The inducible cassette is controllably inserted in such a way to ensure that the genetic material it contains is not silenced or subject to negative influences from the insertion site, and transcription of the genetic material is controlled.

A system and method for photo-thermal imaging of a lateral flow immunoassay (LFA) device are provided. The system includes an intensity modulated heat source directed at a surface of the LFA device to selectively excite chromophore particles of interest and a thermal capture device configured to capture thermal waves emitted from the surface of the LFA device as a radiometric signal. A computing device, in communication with the thermal capture device, receives the radiometric signal and executes lock-in demodulation to detect surface or subsurface inhomogeneities of the LFA device.