The disclosure provides methods of managing opioid therapy, particularly, for pain management. The methods comprise determining in a subject, for example, a subject who has received an opioid treatment, pupillary unrest in ambient light (PUAL). Low values of PUAL can be used to identify patients at risk for opioid side-effects, such as opioid-related respiratory depression (OIRD), and who warrant attention to prevent such side effects. Accordingly, the methods include monitoring the patients having low values of PUAL for signs of adverse side-effects and/or limiting or avoiding administration of opioids.

Deep learning methods and systems for detecting biomarkers within optical coherence tomography volumes using such deep learning methods and systems are provided. Embodiments predict the presence or absence of clinically useful biomarkers in OCT images using deep neural networks. The lack of available training data for canonical deep learning approaches is overcome in embodiments by leveraging a large external dataset consisting of foveal scans using transfer learning. Embodiments represent the three-dimensional OCT volume by “tiling” each slice into a single two dimensional image, and adding an additional component to encourage the network to consider local spatial structure. Methods and systems, according to embodiments are able to identify the presence or absence of AMD-related biomarkers on par with clinicians. Beyond identifying biomarkers, additional models could be trained, according to embodiments, to predict the progression of these biomarkers over time.

A catheter-based device for determining the radial expansion force required to displace an occlusion in a vessel located in a subject. The device comprises an elongate body defining proximal and distal termini. The body comprises a sheath that encloses a hollow lumen within, which extends along substantially the full length of the body. The proximal terminal region of the body comprises: a user-interfacing hub, the hub comprising a handle for maneuvering the body and configured for handling by an operator; a control interface for controlling the device; and a sensor configured to measure one or more parameters relevant to a force applied to the vessel by the device. The distal terminal region of the body comprises an expandable member movable between a retracted position, in which the expandable member is within the hollow lumen, and a deployed position, in which the expandable member is disposed beyond the distal terminus, and controllable via the control interface to expand radially. The expansion of the expandable member is correlated to a defined radial expansion force value.

The present disclosure relates to a system for providing customized cosmetics by using genetic information, the system comprising: a terminal that receives user information related to a user; a genetic/medical information server that stores genetic information related to the user; a skin meter that acquires skin information on the user; and a cosmetic manufacturing system that manufactures cosmetics by discharging at least one cosmetic material, wherein the cosmetic manufacturing system can select a cosmetic material to be discharged on the basis of at least one among the user information, the genetic information, and the skin information.

A wearable device includes: a base to be worn on a head of a user; a first sensor that is provided to the base to be at a distance from a surface of the user's head and measures a first signal relating to a temperature of the surface of the user's head; an estimation circuit that estimates a body temperature of the user based on the first signal; and a display that presents the body temperature of the user estimated by the estimation circuit.

A method of analyzing thoracic insufficiency syndrome (TIS) in a subject by performing quantitative dynamic magnetic resonance imaging (QdMRI) analysis. The QdMRI analysis includes performing four-dimensional (4D) image construction of a TIS subject's thoracic cavity. The 4D image includes a sequence of two dimensional (2D) images of the TIS subject's thoracic cavity over a respiratory cycle of the TIS subject. The QdMRI analysis also includes segmenting a region of interest (ROI) within the 4D image, determining TIS measurements within the ROI, comparing the TIS measurements to normal measurements determined from ROIs in 4D images of the thoracic cavities of normal subjects that are not afflicted by TIS, and outputting quantitative markers indicating deviation of the thoracic cavity of the TIS subject relative to the thoracic cavities of the normal subjects.

A condition visualization system includes a first acquisition unit, an estimation unit, a processing unit, an output unit, a second acquisition unit, and a correction information generation unit. The first acquisition unit acquires a user's biometric information. The estimation unit obtains, based on the biometric information, an estimated value representing the user's mental and physical condition. The processing unit generates, based on the estimated value, mental and physical condition information. The output unit outputs the mental and physical condition information to a display unit. The second acquisition unit acquires a subjective value with respect to the user's mental and physical condition. The correction information generation unit generates correction information by using a plurality of data sets, each including the estimated value and the subjective value. The processing unit generates the mental and physical condition information by making correction to the estimated value based on the correction information.

The conversion adapter is provided that includes a radio communication unit that receives biological information based on the digital data transmitted from an external biological sensor by using radio communication; an information processing unit that performs data processing of the biological information based on the digital data; a converter that converts the biological information based on the digital data processed by the information processing unit to biological information based on analog data; and a connection unit that is connectable through wire to an external biological information monitor and that outputs the biological information based on the analog data converted by the converter.

A fast imaging apparatus and method for high resolution diffuse optical tomography with a line imaging and illumination system is disclosed. The method uses an algorithm comprising a convolution approximation of the forward heterogeneous scattering model that can be inverted to produce deeper than ever before structured beneath the surface. The method can detect reasonably accurate boundaries and relative depth of absorption variations up to a depth of approximately 8 mm below highly scattering medium such as skin.

A portable electronic device configured to be positioned on a users wrist, the portable device being configured to perform an electrocardiogram, ECG, the portable electronic device includes a watchcase, a case back, configured to be at least partially in contact with the skin of the wrist, a glass, a bezel, mounted on the watchcase and surrounding the glass, movable in rotation with respect to the watchcase, a first ECG electrode, made of conductive material, on the case back and configured to be in contact with the skin of the wrist, a second ECG electrode, made of conductive material, on the bezel, an ECG electronic module, electrically connected to the first ECG electrode and the second ECG electrode, and configured to receive and process electrical signals from a user and retrieved by the ECG electrodes, to perform an electrocardiogram.