A photosensitizer and derivative, application thereof. The photosensitizer has the structure of general formula I, wherein X is S or Se, Y is organic or inorganic ion, R.sub.1 and R.sub.2 are independently selected from H, alkyl, alkoxy, alkyl amido, alkyl azide and the like; R.sub.3 is selected from H, alkyl, alkoxy, amino sulfonyl, hydroxyl, carboxyl and the like, and L.sub.1 is a linker selected from —(CH.sub.2).sub.n1— or —(CH.sub.2CH.sub.2O).sub.n2—. The derivatives are molecular medicines with drug molecules of anticancer and chemotherapy or tumor targeting function connected to the said photosensitizer. The photosensitizer has excellent near infrared characteristics and low dark toxicity and is used in the field of photodynamic tumor therapy. The introduction of benzophenothiazine or benzophenoselenazine into derivatives with tumor-targeting function could improve the specific uptake of photosensitizer in tumor tissues. Moreover, clinical anticancer drugs can be introduced into the structure of benzophenothiazine or benzophenoselenazine to achieve the purpose of combining therapy of photodynamic therapy and chemotherapy. ##STR00001##

The invention relates to the field of medical equipment, more specifically to syringes, and can be used for procedures of aspiration of various fluids, for fine needle biopsy, for puncture morphological diagnostics, and for injections of liquid medicinal products. The subject matter of the invention: the disclosed device, including a barrel with a tip for attaching a needle at one end, a piston with a stem slidingly mounted inside the barrel, and a grip at the end of the stem, according to the invention, is provided with a handle moveably coupled to the stem grip and rotatable in relation to a hinge unit located on the stem grip, wherein the handle is at least formed as a bracket with a reverse grip located at the end opposite to the handle attachment and having a slot arranged in the middle portion and intended for enclosing the stem on two sides.

The urine collection insert, or infant urine collector, is an insert for placement inside a typical diaper. Placement of the insertion preferably occurs with the first diapering after birth. The infant's urine is channeled into a portal, through a one-way valve, and into a reservoir. Coincident with the next diaper change, the insert is collected and the urine withdrawn for testing. Throughout the process, all chain-of-custody requirements being followed. The design of the urine collection insert prevents contamination from the infant's feces, most likely to be meconium—the feces of a newborn formed from epithelial cells, lanugo (hair), mucus, amniotic fluid, bile, and water. By avoiding contamination, the integrity of the sample will be maintained and accuracy of results increased, whether positive or negative.

In an example, a method of detecting cyanide exposure of an individual comprises measuring a thiocyanate level of the individual, and comparing the measured thiocyanate level to a preset thiocyanate threshold to determine whether the measured thiocyanate level is above the preset thiocyanate threshold indicating a level of cyanide poisoning requiring immediate medical assessment.

Systems and methods for providing a combined mosquito staging and dissection system are disclosed. The system can include a mosquito staging subsystem; a robotic pick-and-place station; and a dissection, extrusion, collection, and disposal subsystem. The subsystems can include one or more stations to provide orientation, decapitation, extrusion of salivary glands, and disposal of carcasses of the mosquitoes. The resident live sporozoites from the salivary glands can be used to produce Plasmodium SPZ-based vaccines.

Embodiments related to medical imaging devices including rigid imaging tips and their methods of use for identifying abnormal tissue within a surgical bed are disclosed.

Various systems, devices, components, and methods are disclosed for measuring the concentration of an analyte, such as acetone, in a breath sample. The disclosed devices include a breath sample analysis device having a mouthpiece configured to facilitate engagement with a user's mouth to receive a breath sample. The disclosed devices also include a breath sample capture cartridge containing an interactant that extracts the analyte from a breath sample passed through the cartridge. Also disclosed are devices for routing the breath sample through the cartridge during exhalation, and for analyzing a reaction in the cartridge to measure a concentration of the analyte.

A biopsy system includes a biopsy device, a control module, and a tissue transport tube. The biopsy device includes a probe, a needle, a cutter, and a transport valve. The needle extends distally from the probe. The cutter is movable relative to the needle and defines a cutter lumen. The holster is configured to couple to the probe. The transport valve is in communication with the cutter lumen. The control module is in communication with the biopsy device and includes a sample management assembly configured to receive one or more tissue samples severed by the cutter. The transport tube extends between the sample management assembly and the biopsy device. The transport tube is in communication with the transport valve such that the transport tube is configured to receive the one or more tissue samples severed by the cutter.

A method and system are disclosed for determining for a female with irregular menstrual cycles a time interval of fertility, comprising receiving, in a processor (11), from a sensor system (22) of a wearable device (2) of the female, physiological data; determining an estimated time to ovulation of the female, by use of a machine learning model and the physiological data; determining the time interval of fertility using pre-determined time thresholds; and generating a message for the female indicating the time interval of fertility.

Disclosed are a biosensor structure for sample measurement and a sample measuring method using same. In a biosensor electrode structure for sample measurement according to an embodiment of the present invention, a working electrode, which is an electrode for measuring a sample, and a reference electrode are arranged to be spaced apart from each other in the longitudinal direction of a sample insertion channel, a working protrusion, which is a protrusion of the working electrode, and two reference protrusions, which are protrusions of the reference electrode, are alternately arranged at a part corresponding to the sample insertion channel, the ratio of the area of the working protrusion to the areas of the reference protrusions is equal to or greater than 1, at least one recognition electrode for recognizing the sample is disposed adjacent to the working electrode or the reference electrode and parallel to the working electrode and the reference electrode while being spaced apart from the working electrode and the reference electrode, and the at least one recognition electrode has at least one recognition protrusion which is a protrusion disposed at the part corresponding to the sample insertion channel.