Herein is reported a method for selecting or deselecting an antibody comprising a) determining for each Asp and Asn residue in an antibody Fv region the conformational flexibility of the C.sub.-atom using a homology model ensemble, b) determining for each Asp and Asn residue in an antibody Fv region the size of the amino acid residue C-terminal to the Asp or Asn residue, and c) selecting an antibody in which the C.sub.a-atom is conformationally inflexible and/or the Asp or Asn has a big C-terminal amino acid residue, or deselecting an antibody in which the C.sub.-atom has a moderate to high conformational flexibility and/or the Asp or Asn has a small C-terminal amino acid residue.

A method, non-transitory computer readable medium, and pharmaceutical assessment computing device that effectively reformulates and repositions pharmaceutical molecule data. With this technology, therapeutic area data comprising a medical condition and pharmaceutical molecule data corresponding to the medical condition is obtained. The pharmaceutical molecule data comprises pharmaceutical molecule identifiers and usage data parameters with corresponding usage data values for each of the pharmaceutical molecule identifiers. Each of the usage data values is compared to a corresponding usage threshold value. Reformulation opportunities are determined for each of the pharmaceutical molecule identifiers comprising a usage data value that exceeds the corresponding usage threshold value. The reformulation opportunities comprise the usage data parameters and associated usage data values corresponding to the pharmaceutical molecule identifiers which comprise a usage data value that exceeds the corresponding usage threshold value. A pharmaceutical molecule report based on the reformulation opportunities is provided.

A method, non-transitory computer readable medium, and pharmaceutical assessment computing device that effectively reformulates and repositions pharmaceutical molecule data. With this technology, therapeutic area data comprising a medical condition and pharmaceutical molecule data corresponding to the medical condition is obtained. The pharmaceutical molecule data comprises pharmaceutical molecule identifiers and usage data parameters with corresponding usage data values for each of the pharmaceutical molecule identifiers. Each of the usage data values is compared to a corresponding usage threshold value. Reformulation opportunities are determined for each of the pharmaceutical molecule identifiers comprising a usage data value that exceeds the corresponding usage threshold value. The reformulation opportunities comprise the usage data parameters and associated usage data values corresponding to the pharmaceutical molecule identifiers which comprise a usage data value that exceeds the corresponding usage threshold value. A pharmaceutical molecule report based on the reformulation opportunities is provided.

A method for determining national crop yields during the growing season using regional agricultural data is provided. In an embodiment, determining national crop yields during the growing season may be accomplished using a server computer system that receives, via a network, agricultural data records that are used to forecast a national crop yield for a particular year. Within the server computer system an agricultural time series module receives one or more agricultural data records that represent a type of covariate data value related to plants at a specific geo-location at a specific time. The agricultural time series module then aggregates the agricultural data records to create one or more geo-specific time series that represent a specific geo-location over a specified time. The agricultural time series module creates one or more aggregated time series that represent geographic areas from a subset of the one or more geo-specific time series. A crop yield estimating module selects a representative feature from the one or more aggregated time series and creates a covariate matrix for each specific geographic area in computer memory of the server computer system. The crop yield estimating module determines a specific state crop yield for a specific year by using a linear regression module to calculate the specific state crop yield from the covariate matrix that represents the specific state for that specific year. The crop estimation module determines a national crop yield for the specific year by using the distribution generation module to calculate the national crop yield for a specific year from the sum of the specific state crop yields for the specific year nationally adjusted using a national yield adjustment module.

A method for sequencing a polynucleotide sample having a barcode sequence includes: introducing a series of nucleotides to the polynucleotide sample according to a predetermined order of nucleotide flows; obtaining a series of signals resulting from the introducing of nucleotides to the polynucleotide sample; and resolving the series of signals over the barcode sequence to render a flowspace string, wherein the flowspace string is a codeword of an error-correcting code that is (i) designed based on and adapted for use with the predetermined order of nucleotide flows, and (ii) capable of distinguishing any codeword in the error-correcting code from the other codewords in the error-correcting code in the presence of zero, one, and two errors.

A method for sequencing a polynucleotide sample having a barcode sequence includes: introducing a series of nucleotides to the polynucleotide sample according to a predetermined order of nucleotide flows; obtaining a series of signals resulting from the introducing of nucleotides to the polynucleotide sample; and resolving the series of signals over the barcode sequence to render a flowspace string, wherein the flowspace string is a codeword of an error-correcting code that is (i) designed based on and adapted for use with the predetermined order of nucleotide flows, and (ii) capable of distinguishing any codeword in the error-correcting code from the other codewords in the error-correcting code in the presence of zero, one, and two errors.

This invention consists of a new analyzer system of the sounds generated in mills that capture the signals issued by the mineral and steel balls cascade that perform grinding. These signals are processed in an embedded system (2) formed by a field programmable gates array (FPGA) and a processor. The system is comprised of an industrial microphone array (1) that captures the sound signals that are converted from analog to digital through and acquisition system (3) specialized in sound signals, processed by a FPGA capable of performing parallel operations at high speed due to the customized hardware developed for this application, and sent to the processor through a high-speed data bus.

Provided are a soil estimation device, a soil estimation method and a program that are capable of improving the accuracy of estimation of a state in soil without increasing the number of sensors that detect the state in the soil. The soil estimation device 100 is provided with an estimated model generation unit 10. The estimated model generation unit 10 generates an estimated model based on at least one among geographical information that specifies a geographical feature of a field of interest and soil distribution information that specifies a soil distribution in the field. The estimated model is a model for estimating, from a measured value that indicates the state in the soil at one location within the field, the state in the soil at a location other than the one location.

A system and method is provided for using a communications network coupling a plurality of computer systems, a database, and a at least one external data source together to facilitate communication therebetween. The plurality of computer systems is configured to extract at least one term from a medical order for the patient, identify at least one medical concept related to an extracted term, and identify at least one medical data element related to an identified medical concept. The plurality of computer system is further configured to query the database for the identified at least one medical data element, query the at least one external data source to retrieve at least one guideline for performing at least one intervention associated with the at least one medical data element, and generate a user interface that displays at least a portion of a result from the queries.

A system and method is provided for using a communications network coupling a plurality of computer systems, a database, and a at least one external data source together to facilitate communication therebetween. The plurality of computer systems is configured to extract at least one term from a medical order for the patient, identify at least one medical concept related to an extracted term, and identify at least one medical data element related to an identified medical concept. The plurality of computer system is further configured to query the database for the identified at least one medical data element, query the at least one external data source to retrieve at least one guideline for performing at least one intervention associated with the at least one medical data element, and generate a user interface that displays at least a portion of a result from the queries.