The present invention relates to a self-assembling polypeptide, such as a silk polypeptide including a spider silk polypeptide, for use as tissue adhesive. The present invention also relates to the use of a self-assembling polypeptide such as a silk polypeptide as tissue adhesive. Further, the invention is directed to the use of a self-assembling polypeptide such as a silk polypeptide to glue one or more cosmetic compounds on skin, mucosa, and/or hair. Furthermore, the invention is directed to a self-assembling polypeptide such as a silk polypeptide for use in gluing one or more pharmaceutical compounds on tissue, skin, mucosa, and/or hair.

A transcatheter heart valve includes a paravalvular seal that is configured for transfemoral delivery. The valve includes a frame and the seal is formed from a plurality of outwardly extending fibers.

Prosthetic valve devices for implantation within a body or lumen that are configured for hemodynamic monitoring. The prosthetic valve device includes one or more sensors in electrical communication with an inductor formed by a portion of the frame or coupled to the frame of the prosthetic valve device. The sensor is configured to measure a flow parameter within the prosthesis. The inductor is configured to relay a signal to an external detector, the signal being associated with the flow parameter measured by the sensor.

A method for making a vascular prosthesis having an outer crimped textile graft and an inner polymeric liner includes securing the polymeric liner to valleys of the crimps of the textile graft while leaving the peaks of the textile graft free of the liner. The polymeric liner is impermeable to blood flow. The inner liner may include expanded polytetrafluoroethylene polymer, and the graft may include polyethylene terephthalate yarns.

An implantable vein frame is contemplated in which two ring members are rigidly joined in spaced axial alignment via one or more interconnecting members. One of the one or more interconnecting members defines a protruding region that acts upon the implant placed within the frame and/or the vein that the vein frame is placed within to define a sinus region. The implant is placed within and scaffolded by the vein frame, and the vein frame is subsequently inserted within a vein via a venotomy, or interposed between two vein segments via vein interposition graft. The vein frame acts to support the structural integrity of the implant, and to scaffold and anchor the implant in place with the vein.

An endovascularly deployed prosthetic includes a portion for being positioned within an ascending aorta. The prosthesis includes a replacement aortic valve on a proximal end thereof. The prosthesis includes an increased diameter portion that seals against the aorta at a more distal portion, and a pair of conduits extend from the increased diameter portion to the coronaries for fluidly coupling the coronaries to the prosthesis.

Embodiments of the instant disclosure relate to intraocular drug delivery devices for and methods of, delivering at least one therapeutic agent to an eye of a subject. Methods include implanting an intraocular implant into the eye and adjacent to a fluid-permeable membrane of the eye of the patient. Intraocular implants are supported in a position at a surface of the fluid-permeable membrane. Intraocular implants include a drug delivery component having at least one therapeutic agent embedded within a non-bioerodible, non-biodegradable polymer matrix. Devices and methods disclosed herein can further include delivering the at least one therapeutic agent to the eye of the subject according to a near zero-order elution rate of the at least one therapeutic agent.

The invention relates to methods of preparing a bone matrix solution, a bone matrix implant, and variants thereof. The invention also relates to methods of cell culture using the same. The invention further relates to bone matrix scaffolds comprising one or more bone matrix nanofibers, methods of preparing, and methods of use thereof. The invention also relates to methods of culturing cells and promoting differentiation of stem cells using the same.

A system for managing female incontinence includes a body of biocompatible material configured to fit between the labia minora and the vestibule floor, the body having a surface configured to occlude the urethral meatus, an adhesive carried on at least a first portion of the surface and configured to provide a sealing engagement between the body and the urethral meatus, and a substance carried by at least one of the body and the adhesive and configured for controlling the odor of the general vaginal-urethral area of a female.

A scleral prosthesis includes an elongated body having a first free end and a second free end opposite the first free end. A maximum width of the body at each end is wider than a maximum width of the body between the ends. The body includes multiple first portions that form the first free end of the body and a part of the body between the ends. The first portions are separated lengthwise along a substantial portion of a total length of the body. The first portions of the body are biased so that they maintain separation from one another without external interference but are configured to be pushed towards each other. The body is configured to receive and retain, between the first portions of the body, an insert that is configured to maintain the separation of the first portions.