A61K36/00

Risk mitigation of infectious disease transmission from incidental and intimate contact using atomic scale molecular disruption and biocidal halo-fullerenes delivered via topical, flushing and enteral mechanisms

The present invention pertains to quantum-scale biocidal particles and chemical reactions that disrupt and eviscerate microbial matter by combining aqueous and dry components. As halo-fullerene activation requires volatile excitation to mix, contact and collide so as to rupture microbial matter, atomic scale chemical reactions impart the requisite movement of engineered halo-fullerenes to destroy bacterial, fungal and viral matter upon contact. The present invention includes two primary mechanisms: an excitation chemistry and biocidal, hydrophobic halo-fullerenes. Upon aqueous exposure, the dry composition initiates a chemical reaction that activates biocidal halo-fullerenes to disrupt biologic surfaces in topical applications. The object of the present invention is a shelf stable, pre-packaged wiping material or dry packet for rehydration with broad spectrum antimicrobial activity. In one example, a matrix or wipe material would be comprised of densely packed and highly concentrated halo-fullerenes and a chemical reaction stimulant. When activated upon aqueous exposure, it would relax water molecules, alter hydrogen binding, and disrupt adhesion and cohesion forces that characterize surface tensions. These dynamics would then isolate sebaceous substances and free oxygen radicals, along with outgassing of carbon dioxide. The chemical reaction stimulant thus transfers energy and hyperactivates otherwise inert halo-fullerenes to form a biocidal composition. Broader utilities range from topical cleansing for personal hygiene, as well as various clinical and surgical procedures, as surgical and prophylactic lavage and rinse solutions, and enteral formulations as a hypertonic renal flush combined with short-acting diuresis. The halo-fullerene and hypertonic renal flush would cause osmotic cellular outflow, mitigate cellular microbial uptake and initial seroconversion and bloodborne events, while a botanical diuretic agent would facilitate systemic prophylaxis or treatment of UTIs.

Risk mitigation of infectious disease transmission from incidental and intimate contact using atomic scale molecular disruption and biocidal halo-fullerenes delivered via topical, flushing and enteral mechanisms

The present invention pertains to quantum-scale biocidal particles and chemical reactions that disrupt and eviscerate microbial matter by combining aqueous and dry components. As halo-fullerene activation requires volatile excitation to mix, contact and collide so as to rupture microbial matter, atomic scale chemical reactions impart the requisite movement of engineered halo-fullerenes to destroy bacterial, fungal and viral matter upon contact. The present invention includes two primary mechanisms: an excitation chemistry and biocidal, hydrophobic halo-fullerenes. Upon aqueous exposure, the dry composition initiates a chemical reaction that activates biocidal halo-fullerenes to disrupt biologic surfaces in topical applications. The object of the present invention is a shelf stable, pre-packaged wiping material or dry packet for rehydration with broad spectrum antimicrobial activity. In one example, a matrix or wipe material would be comprised of densely packed and highly concentrated halo-fullerenes and a chemical reaction stimulant. When activated upon aqueous exposure, it would relax water molecules, alter hydrogen binding, and disrupt adhesion and cohesion forces that characterize surface tensions. These dynamics would then isolate sebaceous substances and free oxygen radicals, along with outgassing of carbon dioxide. The chemical reaction stimulant thus transfers energy and hyperactivates otherwise inert halo-fullerenes to form a biocidal composition. Broader utilities range from topical cleansing for personal hygiene, as well as various clinical and surgical procedures, as surgical and prophylactic lavage and rinse solutions, and enteral formulations as a hypertonic renal flush combined with short-acting diuresis. The halo-fullerene and hypertonic renal flush would cause osmotic cellular outflow, mitigate cellular microbial uptake and initial seroconversion and bloodborne events, while a botanical diuretic agent would facilitate systemic prophylaxis or treatment of UTIs.

MORINGA PEREGRINA SEED EXTRACT RICH IN 2,5-DIFORMYLFURAN, PROCESS FOR OBTAINING SAME AND USE THEREOF IN COSMETIC COMPOSITIONS
20230133310 · 2023-05-04 ·

The invention relates to an extract of Moringa peregrina seeds rich in the compound 2,5-diformylfuran, more specifically an extract of the cake of said seeds, and to a process for extracting the extract. The invention also relates to cosmetic or nutricosmetic compositions comprising said extract and to the use of said compositions for improving the appearance of the skin, mucous membranes or the integuments, for relaxing, soothing and destressing the skin and for preventing and/or combating the signs of aging and/or photoaging of the skin, and for preventing age spots.

METHOD FOR PRODUCING AN EXTRACT OF A MATRIX OF VEGETABLE ORIGIN WITH A NON-IONIC AMPHIPHILIC COMPOUND AS EXTRACTION ADJUVANT IN AN AQUEOUS MEDIUM
20170367393 · 2017-12-28 · ·

The invention relates to a method for producing an extract of a matrix of vegetable origin, particularly a plant, involving a solid-liquid extraction by means of an aqueous solution containing at least one, preferably agro-sourced, non-ionic amphiphilic compound, at a concentration at least equal to the minimum hydrotrope concentration thereof.

DRUG COMBINATIONS FOR INHIBITING INFECTIVITY OF INFLUENZA AND CORONA VIRUSES
20230201215 · 2023-06-29 · ·

Drug combinations, compositions including pharmaceutical compositions as well as methods of using and treating a viral infection, the drug combinations including (1) protease inhibitors Camostat, Nafamostat, (2) modulators or inhibitors of intracellular steroid hormone receptors signaling pathways (steroid hormone receptor antagonists), (3) modulators or inhibitors of SKP2 protein, (4) modulators of poly(ADP-ribose) polymerases and (5) angiotensin 2 response modifiers.

Topical cosmetic treatment of skin and scalp and corresponding active ingredient based on an extract of <i>Apium graveolens</i>

The invention provides the use of at least one alkyl-phthalide or a plant extract comprising mainly said alkyl-phthalide for the topical cosmetic treatment of the skin and of the scalp, in particular an anti-dandruff treatment. According to the invention, a CO.sub.2 supercritical extract of Apium graveolens seeds consisting mainly of sedanenolide may be used.

Topical cosmetic compositions

A method of reducing the appearance of dark circles in a periorbital area of a person's face is disclosed. The method can include topically applying to the dark circles a composition comprising an extract of Opuntia ficus-indica to reduce the appearance of the dark circles in the periorbital area of the person's face.

Plant extract for hair tonic for treating baldness and preventing hair loss and hair bulb regenerator
09849078 · 2017-12-26 ·

The present invention relates to an extract from Pteridium Arachnoideum or Pteridium Aquilinum and the preparation process thereof, useful for re-growing hair in subjects who have experienced hair loss due to any cause on head and eyebrow.

Composition for preventing, alleviating, or treating cachexia and muscle loss

The present disclosure relates to a composition containing a Paeoniae radix extract as an active ingredient. The composition may alleviate inappetence, weight loss, muscle loss and fatigue and inhibit hematopoietic toxicity. Thus, the composition may be effectively used for the prevention, alleviation or treatment of cachexia and muscle loss.

Enrichment Method of Ergosterol Peroxide from Sporoderm-Broken Ganoderma Lucidum Spore Powder
20170360802 · 2017-12-21 ·

The invention provides an enrichment method of Ergosterol peroxide from sporoderm-broken Ganoderma lucidum spore powder, comprising the steps of preparing crude extract containing Ergosterol peroxide, purification by medium pressure preparative chromatography, purification by simulated moving-bed, and recrystallization. The operation of this invention is simple and stable, with higher yield and low cost, suiting for industrial continuous production.