A shoe toe shaping clamping device has a mold base and multiple clamping units. The mold base has a mold body. Each clamping unit has a clamping base, a bottom clamping unit, a top clamping unit, a clamping space, and a depth adjusting unit. The bottom clamping unit is mounted on the clamping base, is adjacent to the mold body, and has a bottom clamping surface. The top clamping unit is mounted on the clamping base and has a top clamping surface. The clamping space is formed between the top clamping surface and the bottom clamping surface. The depth adjusting unit is mounted on the bottom clamping unit and shelters two sides of the clamping space. The shoe toe shaping clamping device is applied for clamping a vamp to form a shoe toe.