A method includes forming an antimicrobial blend including an antimicrobial additive combined with a polymer, and forming a medical device with the antimicrobial blend, wherein a surface of the medical device exhibits antimicrobial properties.

The invention relates to a patient interface comprising a plenum chamber, a seal-forming structure, and a positioning and stabilizing structure, as well as the method of operating the patient interface. The patient's interface is configured to leave a patient's mouth uncovered or if the seal-forming structure is configured to seal around a patient's nose and mouth, the patient interface is configured to allow the patient to breath from the ambient in an absence of the flow of pressurized. The positioning and stabilizing structure includes headgear, and the seal-forming structure and at least a portion of the headgear is formed from a one piece construction of textile material. In another embodiment, the seal-forming structure and/or the positioning and stabilizing structure includes an adaptive portion that adjusts based on usage conditions. In another embodiment, the positioning and stabilizing structure, the seal-forming structure and/or the plenum chamber includes and/or is formed of a textile material, and the textile material includes at least one magnetic thread constructed of magnetic material to provide a magnetic interaction between a first part of the patient interface and a second part of the patient interface. In another embodiment, a stiffener is coupled to the plenum chamber, the seal-forming structure, and/or the positioning and stabilizing structure. In another embodiment, at least one of the plenum chamber and the seal-forming structure includes a textile material; and wherein the textile material includes a surface structure that limits adhesion of debris. A UV cleaning receptacle of the patient interface is also disclosed.

A medical device includes a multi-layer body defining an interior space configured to contain a liquid. The multi-layer body includes a solid outer wall having a positive Poisson's ratio and a porous inner wall having a negative Poisson's ratio. A method of making a multi-layer body includes applying a stimulus to a precursor material to cause the precursor material to form a porous wall having a negative Poisson's ratio, and attaching a solid wall to the porous wall to form the multi-layer body, the solid wall having a positive Poisson's ratio. A suture includes one or more filaments, at least a first filament of the one or more filaments including a negative Poisson's ratio material. A medical device includes a biocompatible hydrogel, and the biocompatible hydrogel includes a composite of a first material having a negative Poisson's ratio and a second material having a positive Poisson's ratio.

A “replaceable cushion system” allows for a cushion frame with an integral cushion (e.g., a gel bladder) to be quickly and easily swapped in and out of a respiratory mask (e.g., a CPAP mask) while maintaining an effective seal via the compression of a gasket. In all of the preferred embodiments, the cushion frame (with an affixed cushion) is removably attached to a mask shell by a press-fit and by associated prongs and notches. The prongs can be located in the mask shell with the notches in the cushion frame, or vice versa.

The present invention relates to a skin administration system capable of improving the efficiency of skin delivery of an ingredient for controlling release of neurotransmitters and, particularly, to a microneedle containing an ingredient for controlling release of neurotransmitters.

Disclosed herein are methods for overfilling primary packaging components, and drug products prepared according to those methods. The methods may include introducing a volume of a formulated drug substance into a primary packaging component having a nominal volume, where the volume of the formulated drug substance is greater than the nominal volume of the primary packaging component. In some cases, the primary packaging component may be a prefillable syringe.

A chest valve including: a housing including an inlet configured to connect to a chest tube, an outlet and a fluid passage from the inlet to the outlet; and a one-way valve within the housing and included in the flow passage, wherein the one-way valve includes: (i) a first tubular strip wherein having an internal air passage and a first layer defining the air passage, wherein the first layer has a first thickness and the internal air passage of the first tubular strip is included in fluid passage of the housing; and (ii) a second tubular strip wherein having a second layer with a second thickness with a second thickness greater than the first thickness, wherein an outer surface of the second tubular strip is adjacent and overlaps an outer surface of the first tubular strip.

A dressing for treating tissue with negative pressure is provided herein comprising a composite of dressing layers, including a release film, a perforated coated polymer film, a manifold, and an adhesive cover. Additionally, a method of manufacturing the dressing may comprise applying a cross-linkable polymer to a polymer film, curing the cross-linkable polymer to a gel layer to form a coated polymer film, and perforating the coated polymer film to form fluid restrictions, such as slits and/or slots, though the coated polymer film.

A plunger (1) for a medical delivery device comprises: a rod element (2) having a distal end (22) and a proximal end, and a stopper (3) mounted to the rod element (2) at its distal end (22). The rod element (2) has a first form fit structure (24) and the stopper (3) has a second form fit structure (31). The stopper (3) is locked to the rod element (2) by the first form fit structure (24) of the rod element (2) and the second form fit structure (31) of the stopper (3) engaging each other.

Apparatus is disclosed for ventilation using an airbag, which may also be operable manually. The apparatus comprises: means providing or penetrable to form an aperture in the airbag; retractable means provided separately from the airbag, for extending in the airbag; fixing means for fixing, by an operator, an end of the retractable means to the airbag via the aperture; actuation means, for repeatedly retracting the retractable means at least partially through the aperture in the airbag to collapse the airbag, and for enabling expansion of the airbag to an expanded state; and connecting means for connecting the actuation means to the airbag and for preventing environment egress of gas from within the airbag between the aperture and the actuation means.