The present invention aims to provide a method for producing a microneedle device comprising a coating comprising dexmedetomidine and isoproterenol, in which the stability of isoproterenol during production and after production of the microneedle device is high. A method for producing a microneedle device according to one embodiment of the present invention comprises coating microneedles with a coating liquid to form a coating on the microneedles. The microneedle device comprises a substrate, microneedles disposed on the substrate, and a coating formed on the microneedles. The coating liquid comprises dexmedetomidine or a pharmaceutically acceptable salt thereof, isoproterenol or a pharmaceutically acceptable salt thereof, ethylenediaminetetraacetic acid or a pharmaceutically acceptable salt thereof, and a sulfated polysaccharide.

The present invention relates to the field of cancer therapy. In particular, the present invention relates to a method of preventing, treating or inhibiting the development of tumours and/or metastases in a subject by administering one or more immunomodulators into the skin via a microneedle device.

The present invention relates to a cosmetic process for a keratin substance such as the skin or the lips, comprising the steps of: applying onto the keratin substance at least one composition comprising at least one coloring agent; and applying onto the keratin substance, to which the composition has been applied, a microneedle sheet comprising a substrate sheet and a plurality of microneedles on the substrate sheet such that the microneedles are capable of penetrating into the keratin substance. According to the present invention, microneedles can penetrate into a keratin substance to provide the keratin substance with long lasting and uniform color effects.

The present invention relates to a tip for injecting a tattoo dye, the tip comprising: a pressure chamber configured to be able to accommodate liquid; a window provided on one side of the pressure chamber and provided to allow laser irradiated from the outside to pass therethrough so that the laser can reach the liquid accommodated in the pressure chamber; a membrane part provided on one side of the pressure chamber to seal a chamber and configured to be deformable according to pressure generated by the irradiation of the laser to the liquid; a dye chamber which is configured to be able to accommodate a tattoo dye and of which one side is configured to be in fluid communication with the membrane part; a dye supply unit configured to supply a dye to a dye accommodation unit; a first valve for determining whether the dye is flowing from the dye supply unit to the dye chamber; and an inject nozzle provided on one side of the dye chamber and configured to enable the dye accommodated in the dye accommodation unit to be injected to the outside. The tip for injecting a tattoo dye according to the present invention can inject a dye at high pressure without a needle, and thus can relieve pain of a person being tattooed, and has the effect of allowing tattooing to be hygienically performed.

A micropigmentation device and related method of use may be used for micropigmentation and other similar procedures. The micropigmentation device may include two needle tips, which may optionally each be part of a separate needle or may be tips on a single component, such as a single needle. In other embodiments, the device may include pairings of needle tips, such as two components with each having a plurality of needle tips or a plurality of needles grouped into two groupings of needle tips. The device may be used to simulate natural human hair follicles as they grow in pairs.

A wearable device 100 for managing alcohol-driven violence is disclosed. The device 100 comprises a capsule C1 adapted to sense sweat of wearer and detect a level of alcohol in the sweat, a capsule C3 adapted to convert a data detected by the capsule C1 to generate signal activating a capsule C4, a capsule C2 adapted to provide power to the capsule C3, and a capsule C5 adapted to detect a muscle activity of the wearer, wherein the capsule C4 is adapted to inject a drug into the body of the wearer, when activated, and wherein the capsule C5 alerts authorities when no muscle activity is detected.

An injector guard and related method of use may be used for micropigmentation and other similar procedures. The guard may attach to a removable or disposable component, such as an ink cartridge, or may connect to a reusable device, such as a tattoo gun. The guard may be also unitary with the ink cartridge, needle, or micropigmentation device. It may be disposable or may be reusable. It may include a leg which may be used to aid in controlling the position of the micropigmentation tool as well as the depth of penetration of the needle into the dermis, as well as, optionally, the angle of the instrument. The guard may also include a coupling body, which may attach to an ink cartridge or other device or component by a press-fit, snap-fit, friction fit, threading, or other means.

A packaging system for microarrays, such as microarrays of microneedles, comprising inner and outer pouches (500, 5000).

The present disclosure relates to a method for manufacturing a microneedle containing a coating part on a needle tip and an apparatus used for the method. When a microneedle is manufactured using the coating method and apparatus according to the present disclosure, a coating part in which a target material is impregnated can be easily inserted into skin and effective dissolution is possible. Further, the target material is allowed to show excellent skin permeability with the dissolution of the coating part of the microneedle manufactured according to the present disclosure, thereby a quantitative amount of target material can be effectively delivered into the skin.

An application device for a fluid delivery includes a housing having a bore extending from a bottom of the housing. The bore is sized and shaped for receiving at least a portion of the fluid delivery apparatus. The application device also includes an impact component for impacting the fluid delivery apparatus and moving at least a portion of the fluid delivery apparatus towards a user's skin. The application device includes a safety arm that is positionable relative to the impact component between a locked configuration in which the impact component is secured in a safety position, and a released configuration in which the impact component is free to move within the housing for impacting the fluid delivery apparatus.