A centrifuge (1) for separating intermixed particulate material of different specific gravity. The centrifuge (1) comprising a centrifuge bowl (10) having a plurality of annular recesses (19), a housing (30), an inlet (17), and means for rotating the centrifuge bowl (10) about the central axis (15). An annular cavity (31) is defined between the housing (30) and the centrifuge bowl (10). The annular cavity (31) is fluidly connected to the plurality of annular recesses (19) on the inner surface of the centrifuge bowl by a number of perforations in the centrifuge bowl wall (12). The annular cavity (19) has a fluid inlet to provide fluid into the annular cavity. The annular cavity (19) has an accumulated cross-sectional flow area (Allow) at two different heights in the annular cavity that differs by at least a factor 10.

A pot for centrifugal separation of a biological fluid into multiple components. The pot comprises a wall (111) around a central axis (112), a top end (121) and a bottom end (113). The pot also comprises a plurality of baffles (114) protruding from the wall (111) into an inner volume of the pot, and/or a protrusion from the bottom end into the inner volume and around the central axis. Also, a consumable cartridge comprising the pot, a cartridge body adapted to receive the pot, and a first holding means. The first holding means is for holding the pot at least partly within the cartridge body, and is adapted to allow the pot to rotate.

An apparatus for facilitating particle separation by density includes a separator having an inner surface surrounding a rotation axis and defining a particle path from an input end to an axially spaced output end. The inner surface includes a plurality of axially spaced dividers having respective inner positions, defining at least in part respective axially spaced retainers for collecting particles during rotation of the separator. The retainers each include at least one fluid inlet for fluidizing particles in the retainer during operation. The dividers include a first pair of adjacent dividers and a second pair of adjacent dividers, the first pair nearer the input end than the second pair, wherein a first divider slope of the first pair is greater than a second divider slope of the second pair and wherein each of the first and second divider slopes is zero or positive. Other systems, apparatuses and methods are disclosed.

A device and method for forming fibrin foam, preferably utilizing a single container, comprising a base structured to be rotationally driven and including a separation chamber disposed and structured to receive a blood sample therein. The base includes a reaction chamber disposed in fluid communication with said separation chamber. The blood sample is separated into a plasma segment and a packed cell segment when subjected to sufficient centrifugation concurrent to the driven rotation of the base. According to structural features, and in some instances concurrent and continuous centrifugation, the plasma segment is directed from said separation chamber into said reaction chamber which includes sufficient quantities of gas and reactant composition to facilitate formation of fibrin foam therein concurrent to centrifugation. Further centrifugation of the fibrin foam and the inclusion of additional features such as a pressurized reaction chamber facilitate the formation of fibrin foam exhibiting varying chemical and/or physical properties.

A liner for a filter sub-assembly has a wall having an outermost surface and an innermost surface. The innermost surface bounds a cavity extending between opposing first and second ends of the liner. A portion of the outermost surface is textured. The liner may be used in a rotor of a filter assembly.

A liner for a filter sub-assembly has a wall having an outermost surface and an innermost surface. The innermost surface bounds a cavity extending between opposing first and second ends of the liner. A portion of the outermost surface is textured. The liner may be used in a rotor of a filter assembly.

Centrifugal contactors that can be used for mixing or separating materials are described. The contactors include a sensing system including a communications fiber within the shaft of the contactors and access ports providing access from the communications fiber to the mixing/separating zone of the contactor. The sensing system can be utilized during operation of the contactor and can provide for detailed and accurate on-line characterization of a protocol, as well as process control and system modification as necessary during operation.

Particles are separated from a source viscoplastic fluid by flowing streams of the viscoplastic fluid and a destination fluid in parallel streamed relationship inside a rotating cylindrical annulus by using baffles to introduce each fluid independently at an inlet lower end of the annulus and for separating the upper streams consisting of an un-yielded source and destination flow proximate the radially innermost side of the annulus, a bulk axial flow in a more central region and a yielded layer destination flow adjacent the radial outermost side of the annulus which contains the particles that have separated. Inlet and outlet baffles are provided at each end of the vertically oriented device to maintain the flows discrete on entry and to maintain the separated flows discrete on exit so as to facilitate removal of the component flows from the fractionator.

Particles are separated from a source viscoplastic fluid by flowing streams of the viscoplastic fluid and a destination fluid in parallel streamed relationship inside a rotating cylindrical annulus by using baffles to introduce each fluid independently at an inlet lower end of the annulus and for separating the upper streams consisting of an un-yielded source and destination flow proximate the radially innermost side of the annulus, a bulk axial flow in a more central region and a yielded layer destination flow adjacent the radial outermost side of the annulus which contains the particles that have separated. Inlet and outlet baffles are provided at each end of the vertically oriented device to maintain the flows discrete on entry and to maintain the separated flows discrete on exit so as to facilitate removal of the component flows from the fractionator.

The present invention provides a nanoparticle mass purification system capable of purifying nanoparticles at high yield and high purify from a nanoparticle synthesis stock solution synthesized in large quantities, and reusing the used solvent by recovery, and a nanoparticle mass purification method using same.