Disclosed is a method for improving affinity of an antibody for an antigen, comprising, in an unmodified antibody, improving affinity for an antigen as compared to the unmodified antibody, by changing 77th, 79th and 81st amino acid residues of a light chain defined by Kabat method to charged amino acid residues.

Provided is a computer-implemented method for determining a communication status in a train consist operating in a distributed power system, the train consist including a lead locomotive and a plurality of remote locomotives. The method includes, for each remote locomotive of the plurality of remote locomotives that receives the command message directly from the lead locomotive, setting the message source indicator of the remote locomotive to a first state representative of a direct receipt of the command message, incrementing the message source counter for each response message received by the remote locomotive from other remote locomotives in which the respective message source indicator is set to the first state, generating a response message including a value of the message source indicator and a value of the message source counter, and transmitting the response message. A system and computer program product are also disclosed.

The present disclosure relates to an automatic train operation system in railway vehicles, the system including: a speed profile generation unit configured to generate speed profile information based on limited speed profile inputted from outside; a track database stored with track gradient information and track curvature information for each track segment; a train speed controller configured to control a speed of the train using a current position, a current speed and the speed profile information of the train inputted from outside; and a propulsion system fault diagnosis unit configured to diagnose a fault status of the propulsion system based on the current speed of the train, the track gradient information, the track curvature information and propulsion notch information inputted from the train speed controller, and to calculate a performance depreciation ratio when the propulsion system is faulted and to provide the performance depreciation ratio to the train speed controller.

A method and system are provided to obtain, with one or more processors, a speed profile of a vehicle system for a designated route traveled by the vehicle system. The designated route includes a plurality of segments, and the speed profile includes a planned segment speed for each segment. One or more planned segment speeds are identified that correspond to a point of interest, and respective priorities are assigned to the identified segment speeds based on the point of interest forming prioritized segment speeds. First discrete numeral values are displayed on a display, representing the planned segment speeds of the prioritized segments that are within a predetermined distance forward of a motion of the vehicle system. Second discrete numeral values are displayed on the display, corresponding to remaining segment speeds that are within the predetermined distance, until a predetermined threshold of discrete numeral values is reached.

A method for managing a service schedule of a vehicle includes receiving the service schedule of the vehicle that travels along a predetermined route from a control server, generating first service information of the vehicle based on position information of the vehicle, generating service state information of the vehicle based on the service schedule and the first service information, and displaying the service state information of the vehicle using a user interface.

A method for managing a service schedule of a vehicle includes receiving the service schedule of the vehicle that travels along a predetermined route from a control server, generating first service information of the vehicle based on position information of the vehicle, generating service state information of the vehicle based on the service schedule and the first service information, and displaying the service state information of the vehicle using a user interface.

A control system identifies vehicle systems for combining into a larger convoy. Each the vehicle systems is formed from at least one propulsion-generating vehicle and at least one non-propulsion-generating vehicle. The control system directs the identified vehicle systems to couple with each other for travel as the convoy from a first location toward a different, second location. The control system directs a first vehicle system in the convoy to separate from the convoy and/or a second vehicle system to join the convoy by coupling with at least one of the vehicle systems in the convoy in an intermediate location between the first and second locations. The vehicles in each of the vehicle systems in the convoy remain connected during separation of the first vehicle system from the convoy and/or during joining of the second vehicle system to the convoy.

The invention relates to systems and methods that provide a higher degree of precision and a greater coordination of vehicle movement than is possible in conventional systems. A control system is designed to enforce vehicle movement along a route to a position versus time trajectory. The control system includes control equipment on the vehicle that reports its location on the track periodically. The controlling computer receives the report, and knowing where the vehicle should be and how fast it should be traveling at that point in time via a run definition table prepared for the route, calculates a position and velocity error, then calculates and sends a tractive effort adjustment command to the vehicle that attempts to reduce the position and velocity error. The invention includes a method for providing an estimated force command for a given target velocity and acceleration that can be used in the overall control methodology.

The invention relates to systems and methods that provide a higher degree of precision and a greater coordination of vehicle movement than is possible in conventional systems. A control system is designed to enforce vehicle movement along a route to a position versus time trajectory. The control system includes control equipment on the vehicle that reports its location on the track periodically. The controlling computer receives the report, and knowing where the vehicle should be and how fast it should be traveling at that point in time via a run definition table prepared for the route, calculates a position and velocity error, then calculates and sends a tractive effort adjustment command to the vehicle that attempts to reduce the position and velocity error. The invention includes a method for providing an estimated force command for a given target velocity and acceleration that can be used in the overall control methodology.

There is described systems and methods for managing an electrical surge of railway signaling equipment. A breaker includes a mechanical reset button that shifts positions in response to detecting the electrical surge exceeding a threshold amperage. An opto-isolator deenergizes in response to the position shift of the mechanical reset button. The event recorder transmits an alarm signal to a remote office system in response to the deenergizing of the opto-isolator.