The present invention is a sealable microampule for storage of environment sensitive material which is autosampler compatible and provides a space, small enough to make low volumes of liquid available for auto-injector needle. The microampule fits inside an autosampler vial and breaks open at a certain height to allow stable accommodation inside the autosampler vial. The microampule has a longer length which provides space to apply the force to snap break the seal at the opening level of the autosampler vial.

Method for filling a sterile container, in particular a bottle, with a liquid, wherein a sterile connection is established between a flexible bag and a first opening of the container, a sterile connection is established between a second opening of the container and a source of the liquid to be filled into the container, the liquid is filled into the container, a gas, in particular air, which is present in the container is displaced by the liquid and forced into the flexible bag while increasing the volume of the flexible bag and the connection between the source of liquid and the second opening of the container is severed in a sterile way.

The present invention is directed to methods for filling a container wherein the filled container has no headspace. The present invention is further directed to methods for stabilizing an aqueous drug substance solution by filling a container with the aqueous drug substance solution wherein the filled container has no headspace. The present invention is further directed to methods for detecting headspace in a container.

Disclosed herein are methods for overfilling primary packaging components, and drug products prepared according to those methods. The methods may include introducing a volume of a formulated drug substance into a primary packaging component having a nominal volume, where the volume of the formulated drug substance is greater than the nominal volume of the primary packaging component. In some cases, the primary packaging component may be a prefillable syringe.

A filling device for metered filling of a filling material from a storage container into a dose receiving container. The device includes a single-use isolator with the receiving container provided therein to protect against contamination. The device includes a weighing device for holding and weighing the storage container with its contents outside of the isolator. The device includes a dispensing device inside the isolator to provide a dose-by-dose dispensing of the material. The device includes a conduit arrangement for connecting the storage container and the dispensing device and conveying the material from the storage container to the dispensing device via a removal device for a dose-by-dose removal of the material outside the isolator. The device includes a control device for controlling the removal device based on information from the weighing device about a decrease in weight of a unit consisting of the storage container and its contents during the removal.

A package (1) is configured to store a powdery material (2) which is to be mixed with a solvent to form a medical solution, such as a dialysis solution. The package (1) comprises a filled cavity portion (6a) containing the powdery material (2), optionally separated into groups of different composition, and a tab portion (9) integrally formed with the filled cavity portion (6a) and being swept around the filled cavity portion (6a) so as to define a roll-up package. The tab portion (9) forms a protective barrier that shields the powdery material (2), e.g. by counteracting transport of moisture into and out of the package. The tab portion (9) may also stabilize the package. The roll-up package is compact, and simple to manufacture and handle.

The present invention provides a filling nozzle obtained by using a resin selected from a cycloolefin polymer and a cycloolefin copolymer, or a filling nozzle including a tubular passage for supplying a pharmaceutical solution, and a filling port disposed at a lower end of the tubular passage, in which the tubular passage and the filling port have a circular peripheral cross-section, and an inner diameter of the passage of the filling port is larger than an inner diameter of the tubular passage disposed on an upstream side.

System for providing marked containers comprising a computerised control system storing at least one unique identifier for each container, to be applied to a respective container, a printing unit comprising an ink delivery station, operatively connected with said computerised control system, able to print said identifier on each container, comprising a printing head filled with ink and having a plurality of nozzles configured for spraying said ink on an external surface of each container, displacement means able to perform a relative rotation, translation or rotary translation between each container and the printing head during the printing of the identifier on the container, said displacement means being operatively connected with said computerised control system.

A fluid manifold system includes a first manifold having portions of opposing flexible sheets welded together to form a fluid flow path therebetween, a fluid inlet communicating with the fluid flow path. The fluid flow path of the first manifold includes: a primary flow path communicating with the fluid inlet of the first manifold; and a plurality of spaced apart secondary flow paths that branch off of the primary flow path. Each secondary flow path has a first end communicating with the primary flow path and an opposing second end, each secondary flow path having a diameter that is smaller than a diameter of the primary flow path. The fluid manifold system also includes a plurality of tubular connectors with each tubular connector being secured to the first manifold at the second end of a corresponding one of the secondary flow paths.

A system for dispensing a liquid in a closed chamber includes at least one rapid transfer port in at least one wall of the closed chamber. In addition, a liquid is dispensed in a closed chamber that includes at least one rapid transfer port in at least one wall of the closed chamber.