In a method for synthesizing 1,1-diamino-2,2-dinitroethylene (FOX-7) or an N-substituted diamino derivative thereof or a salt of 1,1-diamino-2,2-dinitroethylene or of the N-substituted diamino derivative, a carbodiimide is reacted with a dinitromethane anion. The reaction of the carbodiimide with the dinitromethane anion takes place in a solution.

In a method for synthesizing 1,1-diamino-2,2-dinitroethylene (FOX-7) or an N-substituted diamino derivative thereof or a salt of 1,1-diamino-2,2-dinitroethylene or of the N-substituted diamino derivative, a carbodiimide is reacted with a dinitromethane anion. The reaction of the carbodiimide with the dinitromethane anion takes place in a solution.

A method for producing a carbodiimide compound, comprising a carbodiimide production step of reacting an aliphatic tertiary isocyanate compound (A) in the presence of an organic alkali metal compound (B) having Lewis basicity.

A method for producing a carbodiimide compound, comprising a carbodiimide production step of reacting an aliphatic tertiary isocyanate compound (A) in the presence of an organic alkali metal compound (B) having Lewis basicity.

This invention relates to the use sigma-2 receptor antagonists, and of pharmaceutical compositions comprising such compounds, in methods for inhibiting Abeta-associated synapse loss or synaptic dysfunction in neuronal cells, modulating an Abeta-associated membrane trafficking change in neuronal cells, and treating cognitive decline associated with Abeta pathology and more broadly treating with such compounds and compositions neurodegenerative diseases and disorders associated with Abeta pathology. This invention also relates to methods for screening compounds for activity in inhibiting cognitive decline on the basis of their ability to bind to a sigma-2 receptor.

This invention relates to the use sigma-2 receptor antagonists, and of pharmaceutical compositions comprising such compounds, in methods for inhibiting Abeta-associated synapse loss or synaptic dysfunction in neuronal cells, modulating an Abeta-associated membrane trafficking change in neuronal cells, and treating cognitive decline associated with Abeta pathology and more broadly treating with such compounds and compositions neurodegenerative diseases and disorders associated with Abeta pathology. This invention also relates to methods for screening compounds for activity in inhibiting cognitive decline on the basis of their ability to bind to a sigma-2 receptor.

The invention relates to novel carbodiimides having terminal urea and/or urethane groups, to processes for the production thereof and to the use thereof as a stabilizer in ester-based polymers especially in films for protection from hydrolytic degradation.

The invention relates to novel carbodiimides having terminal urea and/or urethane groups, to processes for the production thereof and to the use thereof as a stabilizer in ester-based polymers especially in films for protection from hydrolytic degradation.

Provided are a polycarbodiimide compound and a polyester resin composition and polyester resin modifier using the polycarbodiimide compound, the polycarbodiimide compound having a small amount of residual amine and having good processability when the polycarbodiimide compound is added to the polyester resin while keeping hydrolysis resistance of polyester resin imparted thereto through addition of the polycarbodiimide compound. A polycarbodiimide compound represented by the following general formula (1): R.sub.mNH.sub.2-m—CO—NH—Z—(N═C═N—Z).sub.n—NH—CO—NH.sub.2-mR.sub.m (1) is used, wherein R.sub.m is a hydrocarbon residue of an amine compound which is represented by R.sub.mNH.sub.3-m and has a boiling point at 1 atm of 150° C. or lower; m is 1 or 2; Z is a residue obtained by removing two isocyanate groups from an aliphatic diisocyanate compound; and n is any integer of 2 to 7.

Provided are a polycarbodiimide compound and a polyester resin composition and polyester resin modifier using the polycarbodiimide compound, the polycarbodiimide compound having a small amount of residual amine and having good processability when the polycarbodiimide compound is added to the polyester resin while keeping hydrolysis resistance of polyester resin imparted thereto through addition of the polycarbodiimide compound. A polycarbodiimide compound represented by the following general formula (1): R.sub.mNH.sub.2-m—CO—NH—Z—(N═C═N—Z).sub.n—NH—CO—NH.sub.2-mR.sub.m (1) is used, wherein R.sub.m is a hydrocarbon residue of an amine compound which is represented by R.sub.mNH.sub.3-m and has a boiling point at 1 atm of 150° C. or lower; m is 1 or 2; Z is a residue obtained by removing two isocyanate groups from an aliphatic diisocyanate compound; and n is any integer of 2 to 7.