Patent classifications
C07C329/00
AMPHIPHILIC RAFT AGENT
This invention relates to a RAFT agent formula (I).
##STR00001##
Enaminone-grafted trithiocarbonate with anticancer and antimicrobial activity
The present subject matter is directed to an enaminone-grafted trithiocarbonate compound having the structure: ##STR00001##
and the anticancer and antimicrobial activities exhibited by the compound.
Synthesis and antimicrobial use of a trithiocarbonate derivative
A method for preparing a trithiocarbonate derivative compound includes reacting ethyl cyanoacetate, carbon disulfide (CS.sub.2) and ethyl chloroacetate in the presence of potassium carbonate (K.sub.2CO.sub.3) in an organic solvent to produce 2,2-(thiocarbonylbis(sulfanediyl))diacetate compound, represented by the structural formula: ##STR00001##
Synthesis and antimicrobial use of a trithiocarbonate derivative
A method for preparing a trithiocarbonate derivative compound includes reacting ethyl cyanoacetate, carbon disulfide (CS.sub.2) and ethyl chloroacetate in the presence of potassium carbonate (K.sub.2CO.sub.3) in an organic solvent to produce 2,2-(thiocarbonylbis(sulfanediyl))diacetate compound, represented by the structural formula: ##STR00001##
WATER SOLUBLE CHAIN TRANSFER AGENTS
The disclosed technology relates to water soluble, or partially water soluble, chain transfer agents for preparing water soluble polymers by Reversible Addition-Fragmentation Chain Transfer (RAFT) polymerization in an aqueous medium.
Phosphonate and phosphonic acid raft agents and monomers, along with methods of their manufacture and use
A RAFT agent is provided that includes a thiocarbonylthio-containing organic compound having a phosphonic end group. The RAFT agent can have the formula: ##STR00001## wherein Z is an organic linkage; R.sub.1 is H or an alkyl group; R.sub.2 is H or an alkyl group; A is O, S, or NH; and R is an organic end group. A method is also provided for forming a polymer chain on a surface of a nanoparticle. The method can include: attaching a RAFT agent to the surface of the nanoparticle such that the phosphonic group of the RAFT agent is covalently bonded to the surface of the nanoparticle; and attaching a polymer to the RAFT agent.
Phosphonate and phosphonic acid raft agents and monomers, along with methods of their manufacture and use
A RAFT agent is provided that includes a thiocarbonylthio-containing organic compound having a phosphonic end group. The RAFT agent can have the formula: ##STR00001## wherein Z is an organic linkage; R.sub.1 is H or an alkyl group; R.sub.2 is H or an alkyl group; A is O, S, or NH; and R is an organic end group. A method is also provided for forming a polymer chain on a surface of a nanoparticle. The method can include: attaching a RAFT agent to the surface of the nanoparticle such that the phosphonic group of the RAFT agent is covalently bonded to the surface of the nanoparticle; and attaching a polymer to the RAFT agent.