The invention relates to a preparation method of (4-isopropoxy-2-methyl)phenyl isopropyl ketone, particularly the preparation method includes: reacting m-cresol with thiocyanate in the presence of a catalyst to obtain a product A; reacting the product A with haloisopropane in the presence of a base and a catalyst to obtain a product B; reacting the product B with isopropyl magnesium halide and treating to obtain (4-isopropoxy-2-methyl)phenyl isopropyl ketone. The purity of (4-isopropoxy-2-methyl)phenyl isopropyl ketone prepared is more than 99%, and the total yield is more than 79%. The method according to the present invention avoids the use of toxic reagents and the generation of a large amount of acidic wastewater, reduces the reaction temperature, and improves the reaction yield. The process route is simple and efficient, and the cost is reduced. The purity of the resulting product is high, the production security is greatly improved, and the method is easy to industrialize.

The present invention relates to compounds useful as inhibitors of ATR protein kinase. The invention relates to pharmaceutically acceptable compositions comprising the compounds of this invention; methods of treating of various diseases, disorders, and conditions using the compounds of this invention; processes for preparing the compounds of this invention; intermediates for the preparation of the compounds of this invention; and solid forms of the compounds of this invention. The compounds of this invention have formula I-A or I-B: ##STR00001##
wherein the variables are as defined herein.

The present invention relates to compounds useful as inhibitors of ATR protein kinase. The invention relates to pharmaceutically acceptable compositions comprising the compounds of this invention; methods of treating of various diseases, disorders, and conditions using the compounds of this invention; processes for preparing the compounds of this invention; intermediates for the preparation of the compounds of this invention; and solid forms of the compounds of this invention. The compounds of this invention have formula I-A or I-B: ##STR00001##
wherein the variables are as defined herein.

Disclosed herein are processes for preparing certain intermediates useful in the synthesis of 3-fluoro-5-(((1S,2aR)-1,3,3,4,4-pentafluoro-2a-hydroxy-2,2a,3,4-tetrahydro-1H-cyclopenta[cd]inden-7-yl)oxy)benzonitrile or a pharmaceutically acceptable salt thereof.

Described herein is a hydroformylation catalyst system and method useful for producing aldehydes from olefin substrates, without using carbon monoxide gas. The hydroformylation catalyst system includes a hydroformylation catalyst complex including a Group 9 metal complexed with a phosphine-based ligand; a syngas surrogate including formic acid and an anhydride compound, which forms carbon monoxide in situ; and hydrogen, which may derive from the syngas surrogate or not derived from the syngas surrogate. The method involves reacting the olefin substrate with a syngas surrogate in the presence of a hydroformylation catalyst complex, wherein the syngas surrogate forms carbon monoxide, and optionally hydrogen, in situ, and then isolating the aldehyde compound from a reaction mixture.

Described herein is a hydroformylation catalyst system and method useful for producing aldehydes from olefin substrates, without using carbon monoxide gas. The hydroformylation catalyst system includes a hydroformylation catalyst complex including a Group 9 metal complexed with a phosphine-based ligand; a syngas surrogate including formic acid and an anhydride compound, which forms carbon monoxide in situ; and hydrogen, which may derive from the syngas surrogate or not derived from the syngas surrogate. The method involves reacting the olefin substrate with a syngas surrogate in the presence of a hydroformylation catalyst complex, wherein the syngas surrogate forms carbon monoxide, and optionally hydrogen, in situ, and then isolating the aldehyde compound from a reaction mixture.

The present invention relates to a new compound and the dehydrogenation of that compound to produce retinal.

Provided are a fluorine-containing ether compound that can form a surface layer that excels in durability and a method of manufacturing the same, a fluorine-containing ether composition and a coating liquid, and an article having a surface layer that excels in durability and a method of manufacturing the same. A fluorine-containing ether compound is expressed by the following formula (A1) or (A2):

{R.sup.fO—(R.sup.f1O).sub.m1—(R.sup.1).sub.m2—(CHF).sub.m3—O—(CHF).sub.m4}.sub.n1-Q.sup.1(-T.sup.1).sub.n2   Formula (A1)

(T.sup.2).sub.n3-Q.sup.2-(CHF).sub.m5—O—(CHF).sub.m6—(R.sup.2).sub.m7—O—(R.sup.f2O).sub.m8—(R.sup.3).sub.m9—(CHF).sub.m10—O—(CHF).sub.m11-Q.sup.3(-T.sup.3).sub.n4  Formula (A2), in the above, the symbols in the formulas are as described in the specification.

A process for the construction of a second chemical plant, which second chemical plant is suitable for the separation of cyclohexanone from a second mixture, which second mixture comprises reaction products from the hydrogenation of phenol, said process comprising: a) providing a first chemical plant, which first chemical plant is suitable for the separation of cyclohexanone from a first mixture, which first mixture comprises reaction products from the oxidation of cyclohexane, and which first plant comprises: i) a distillation column (C) suitable for distilling overhead cyclohexane; ii) a distillation column suitable for distilling overhead cyclohexanone; iii) a cyclohexane oxidation unit (A) suitable for the oxidation of cyclohexane; and iv) a heat recovery unit (B) suitable for the recovery of heat from off-gas from the cyclohexane oxidation unit suitable for the oxidation of cyclohexane; b) disabling in said first chemical plant, said distillation column (C) suitable for distilling overhead cyclohexane, said cyclohexane oxidation unit (A) and said heat recovery unit (B), wherein the second chemical plant comprises a distillation column (F) suitable for distilling overhead cyclohexanone reused from the first chemical plant, wherein each of the first chemical plant and the second chemical plant comprise a distillation column (E) suitable for distilling overhead components having a lower boiling point than cyclohexanone; a distillation column (G) suitable for distilling overhead a mixture comprising cyclohexanol and cyclohexanone in a wt.:wt. ratio of at least 4:1; and a cyclohexanol dehydrogenation unit (H) suitable for the dehydrogenation of cyclohexanol to cyclohexanone.

Disclosed herein are processes for preparing certain intermediates useful in the synthesis of 3-fluoro-5-(((1S,2aR)-1,3,3,4,4-pentafluoro-2a-hydroxy-2,2a,3,4-tetrahydro-1H-cyclopenta[cd]inden-7-yl)oxy)benzonitrile or a pharmaceutically acceptable salt thereof.