This disclosure relates to macrocyclic picolinamides of Formula I and their use as fungicides.

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This disclosure relates to macrocyclic picolinamides of Formula I and their use as fungicides.

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This disclosure relates to macrocyclic picolinamides of Formula I and their use as fungicides.

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This disclosure relates to macrocyclic picolinamides of Formula I and their use as fungicides.

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Described herein are 1,2-dioxetanes that are useful as chemiluminescent probes, diagnostic agents, and imaging agents. Also described herein are compositions containing such compounds and methods of using the same.

Described herein are 1,2-dioxetanes that are useful as chemiluminescent probes, diagnostic agents, and imaging agents. Also described herein are compositions containing such compounds and methods of using the same.

Turn-ON dioxetane-based chemiluminescence probes based on the Schapp's adamantylidene-dioxetane probe eh are useful for determining the presence, or measuring the level, of Mycobacterium tuberculosis (Mtb)-specific protease in a sample, and for assessing the susceptibility of the Mtb to an antibiotic drug. determining the presence or measuring the level of Mycobacterium tuberculosis (Mtb)-specific protease in the sample can include contacting the sample with a certain compound, and imaging the sample to detect an emission of light.

Turn-ON dioxetane-based chemiluminescence probes based on the Schapp's adamantylidene-dioxetane probe eh are useful for determining the presence, or measuring the level, of Mycobacterium tuberculosis (Mtb)-specific protease in a sample, and for assessing the susceptibility of the Mtb to an antibiotic drug. determining the presence or measuring the level of Mycobacterium tuberculosis (Mtb)-specific protease in the sample can include contacting the sample with a certain compound, and imaging the sample to detect an emission of light.

The present invention relates to a compound of the following formula (I). The invention also relates to uses thereof as a chromophore as such or for building pigments displaying special optical effects, including metal-like reflection. ##STR00001##

The present invention provides a compound that is highly safe and useful in the prevention, alleviation, and/or treatment of various diseases involving enteropeptidase inhibition and/or trypsin inhibition, a pharmaceutical composition containing the compound, a method for producing the compound, and the like. Specifically, the present invention provides a compound represented by the following general formula (I): ##STR00001##
[wherein: A.sup.1 and A.sup.2 each independently represent an inhibitor residue having at least one activity selected from an enteropeptidase inhibitory activity and a trypsin inhibitory activity; and Z represents a spacer that links A.sup.1 to A.sup.2] or a pharmaceutically acceptable salt thereof.