C07H23/00

METHOD OF PREPARING FERRIC CARBOXYMALTOSE

Provided is a method of preparing ferric carboxymaltose with weight average molecular weight between 100,000 and 400,000. The method includes reacting an oxidized maltodextrin solid with an iron (III) salt solution in acidic and basic conditions in sequence to afford ferric carboxymaltose, wherein the oxidized maltodextrin solid has a dextrose equivalent of less than 4. The ferric carboxymaltose prepared by the method can withstand high-temperature sterilization with high stability and facilitate storage.

SEPARATION OF OLIGOSACCHARIDES FROM FERMENTATION BROTH
20180002363 · 2018-01-04 ·

The present invention relates to the isolation and purification of sialylated oligosaccharides from an aqueous medium in which they are produced.

SEPARATION OF OLIGOSACCHARIDES FROM FERMENTATION BROTH
20180002363 · 2018-01-04 ·

The present invention relates to the isolation and purification of sialylated oligosaccharides from an aqueous medium in which they are produced.

NOVEL, HEAVY VITAMIN B12 DERIVATIVES
20180009838 · 2018-01-11 ·

The invention discussed in this application relates to vitamin B12-based compounds that are useful as quantitative standards, particularly for the assessment of vitamin B12 deficiency.

NOVEL, HEAVY VITAMIN B12 DERIVATIVES
20180009838 · 2018-01-11 ·

The invention discussed in this application relates to vitamin B12-based compounds that are useful as quantitative standards, particularly for the assessment of vitamin B12 deficiency.

METHOD FOR PRODUCING GLYCOSIDE COMPOUND

A purpose of the present invention is to provide a method for producing a glycoside compound having a high purity. The present invention provides a method for producing a glycoside compound represented by formula (3) (wherein B.sup.a, i-Pr and n are the same as those defined below), which comprises reacting a glycoside compound of formula (1) (wherein B.sup.a represents an adenine group which may be optionally substituted with an acyl group, and i-Pr represents an isopropyl group) with an ether compound of formula (2) (wherein R.sup.1 represents a C1-C6 alkyl group or a phenyl group, and n is 0 or 1) in one or more solvents selected from tetrahydropyran and 4-methyltetrahydropyran in the presence of one or more halogenated agents selected from halogen, N-halogenated succinimide, and N-halogenated hydantoin.

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METHOD FOR PRODUCING GLYCOSIDE COMPOUND

A purpose of the present invention is to provide a method for producing a glycoside compound having a high purity. The present invention provides a method for producing a glycoside compound represented by formula (3) (wherein B.sup.a, i-Pr and n are the same as those defined below), which comprises reacting a glycoside compound of formula (1) (wherein B.sup.a represents an adenine group which may be optionally substituted with an acyl group, and i-Pr represents an isopropyl group) with an ether compound of formula (2) (wherein R.sup.1 represents a C1-C6 alkyl group or a phenyl group, and n is 0 or 1) in one or more solvents selected from tetrahydropyran and 4-methyltetrahydropyran in the presence of one or more halogenated agents selected from halogen, N-halogenated succinimide, and N-halogenated hydantoin.

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SYNTHESIS OF 3 -RNA OLIGONUCLEOTIDES

Provided is a method of treating cancer cells localized in the lung by administering to such patients a therapeutically effective amount of a liposomal annamycin formulation (L-Ann).

Silicon containing detectable compounds

Disclosed herein, inter alia, are silicon containing detectable compounds and methods of use thereof.

Polymerizable compound, compound, and method for producing boranophosphate oligomer

Provided a polymerizable compound represented by the following Formula A-1 or Formula A-2: In Formula A-1 or Formula A-2, R.sup.1 represents an electron-donating group; n represents an integer from 1 to 5; R.sup.2 represents a hydrogen atom, a halogen atom, or —OR.sup.O, wherein R.sup.O represents a hydrogen atom, an alkyl group, or a protecting group of a hydroxy group; R.sup.3 represents a hydrogen atom or a protecting group of a hydroxy group; and X represents a structure represented by any one of Formula B-1 to Formula B-5.