Patent classifications
C09B1/00
NIR to SWIR fluorescent compounds for imaging and detection
This disclosure provides a family of compounds that absorb and fluoresce in the short wave infrared region (SWIR, optionally 1000 nm to 1300 nm), including hydrophilic compounds that exhibit absorption and emission spectral profiles in aqueous solutions substantially similar to those observed in organic solvents such as methanol or DMSO. The compounds can be chemically linked to biomolecules including proteins, nucleic acids, and therapeutic small molecules. The compounds are useful for imaging in a variety of medical, biological and diagnostic applications, including SWIR in vivo imaging of regions of interest within a mammal.
Heterocyclic compound and organic light-emitting device including the same
A heterocyclic compound and an organic light-emitting device including the same are provided. The heterocyclic compound is represented by Formula 1: ##STR00001## Details of R1, R2, R3, X1, L1, and a1 and b1 are provided in the disclosure.
Heterocyclic compound and organic light-emitting device including the same
A heterocyclic compound and an organic light-emitting device including the same are provided. The heterocyclic compound is represented by Formula 1: ##STR00001## Details of R1, R2, R3, X1, L1, and a1 and b1 are provided in the disclosure.
Laundry care compositions
A laundry care composition comprises a laundry care ingredient or adjunct and at least one compound that is capable of changing from a first color state (i.e., the initial color state in the composition) to a second color state that is perceptibly different from the first color state. A method for treating textile articles comprises the steps of: (a) providing a laundry care composition as described above; (b) adding the laundry care composition to a liquid medium; and (c) placing the textile articles in the liquid medium.
Laundry care compositions
A laundry care composition comprises a laundry care ingredient or adjunct and at least one compound that is capable of changing from a first color state (i.e., the initial color state in the composition) to a second color state that is perceptibly different from the first color state. A method for treating textile articles comprises the steps of: (a) providing a laundry care composition as described above; (b) adding the laundry care composition to a liquid medium; and (c) placing the textile articles in the liquid medium.
OPTICAL FILM AND METHOD OF MANUFACTURING THE SAME, REFLECTIVE LIQUID CRYSTAL DISPLAY PANEL AND DISPLAY APPARATUS
An optical film includes a polarizer. The polarizer includes a base layer, and a material of the base layer is obtained by dyeing a base material with a dye. The base material includes a polyvinyl alcohol material, and the dye is selected from blue dichroism organic dyes.
OPTICAL FILM AND METHOD OF MANUFACTURING THE SAME, REFLECTIVE LIQUID CRYSTAL DISPLAY PANEL AND DISPLAY APPARATUS
An optical film includes a polarizer. The polarizer includes a base layer, and a material of the base layer is obtained by dyeing a base material with a dye. The base material includes a polyvinyl alcohol material, and the dye is selected from blue dichroism organic dyes.
In-vivo probe for real time longitudinal monitoring of inducible nitric-oxide synthase in living cells and animals
The present disclosure relates to an in vivo fluorescent or radioactive probe represented by a compound of formula I which is capable of longitudinal imaging of inducible nitric oxide synthase (iNOS) expression in living cells and living animals on a real time basis. The probe of the present disclosure can exhibit specific and high affinity binding to the iNOS enzyme with reduced enzyme inhibitory property and also enables longitudinal monitoring of iNOS expression along with its activity or NO production in a same experimental subject throughout the progression of a physiological or disease process without employing separate subjects as controls and experimental. The present disclosure further provides a rapid and inexpensive real time method for visualizing iNOS expression and its activity in living cells and living animals precisely, conveniently and reversibly along with simultaneous in vivo imaging of its catalytic product, nitric oxide (NO) in live physiological settings.
In-vivo probe for real time longitudinal monitoring of inducible nitric-oxide synthase in living cells and animals
The present disclosure relates to an in vivo fluorescent or radioactive probe represented by a compound of formula I which is capable of longitudinal imaging of inducible nitric oxide synthase (iNOS) expression in living cells and living animals on a real time basis. The probe of the present disclosure can exhibit specific and high affinity binding to the iNOS enzyme with reduced enzyme inhibitory property and also enables longitudinal monitoring of iNOS expression along with its activity or NO production in a same experimental subject throughout the progression of a physiological or disease process without employing separate subjects as controls and experimental. The present disclosure further provides a rapid and inexpensive real time method for visualizing iNOS expression and its activity in living cells and living animals precisely, conveniently and reversibly along with simultaneous in vivo imaging of its catalytic product, nitric oxide (NO) in live physiological settings.
NIR TO SWIR FLUORESCENT COMPOUNDS FOR IMAGING AND DETECTION
This disclosure provides a family of compounds that absorb and fluoresce in the short wave infrared region (SWIR, optionally 1000 nm to 1300 nm), including hydrophilic compounds that exhibit absorption and emission spectral profiles in aqueous solutions substantially similar to those observed in organic solvents such as methanol or DMSO. The compounds can be chemically linked to biomolecules including proteins, nucleic acids, and therapeutic small molecules. The compounds are useful for imaging in a variety of medical, biological and diagnostic applications, including SWIR in vivo imaging of regions of interest within a mammal.