C12Y111/00

POLYNUCLEOTIDES, POLYPEPTIDES, RECOMBINANT CELLS AND METHODS FOR GENERATING ERGOLINES AND PRECURSORS AND METABOLITES THEREOF

Provided are non-naturally occurring polynucleotide sequences that encode for polypeptides useful in ergoline biosynthesis, as well as the non-naturally occurring polypeptide sequences. Also provided are recombinant host cell and methods for microbial biosynthesis of an ergoline, or a precursor or metabolite thereof, using the recombinant host cell.