Methods for diagnosing a subject as a candidate for removal of a solid tumor without preoperative chemoradiation therapy, and methods for treating patients having solid tumors, who have one or more of genomic instability, elevated double stranded DNA breaks, elevated gamma-H2AX foci, or elevated replication stress and/or double stranded break-signalling (DSB-signalling) biomarkers in peripheral blood lymphocytes (PBLs) are provided herein.

Provided is a method of inspecting a growth quality of a graphene layer of a graphene-grown copper foil obtained by growing the graphene layer on a copper foil layer by chemical vapor deposition (CVD), the method including reacting oxygen or water molecules with the copper foil layer via a defect portion of the graphene layer, partitioning an entire region of the graphene-grown copper foil into partial regions, sequentially obtaining images of the partial regions, detecting, with respect to each of the images of the partial regions, an oxidized region where the copper foil layer is oxidized, and setting the oxidized region as a graphene defect region, and obtaining a ratio of an area of the graphene defect region to an entire area of each of the images of the partial regions.

In order to provide an elemental analysis device that includes an electrode having a housing recess where a crucible is housed during an elemental analysis, and that is capable of making only the part of a consumed electrode tip replaceable, an elemental analysis device including a first electrode and a second electrode between which a crucible MP containing a sample is nipped, and that heats the sample by applying a current between the first electrode and the second electrode, the first electrode includes: a first electrode main body that is provided with a housing recess where the crucible MP is housed; and a first electrode tip that is provided removably to the first electrode main body in such a manner that a part thereof is exposed inside the housing recess.

A real-time online analysis device for substance pyrolysis, including: a pyrolyzing system (1), a capturing system (2), a testing system (3) and a controlling system (4) is disclosed. The pyrolyzing system (1), the capturing system (2) and the testing system (3) are connected with the controlling system (4). The capturing system (2) has a cooling cavity (22) and a heating cavity (23) inside. The temperature of the cooling cavity (22) ranges from room temperature to −200° C., and the temperature of the heating cavity (23) ranges from room temperature to 1000° C. A method for real-time online analysis of substance pyrolysis using the device is also disclosed. The present device can provide real-time online pyrolysis, capturing, separation and analysis of substances at a plurality of temperature points or ranges.

Targeting metastasis stem cells through a fatty acid receptor. The invention provides the use of blockers or inhibitors of CD36 activity or expression for the treatment of oral squamous cell cancer (OSCC), particularly for the treatment of generated metastases and for diminish is generation from primary tumours. Apart from shRNAs, anti-CD36 antibodies are provided as blockers or inhibitors, especially those that block the binding of CD36 to oxidized LDL and fatty acids and their incorporation into cells, because the promotion of their transport is indicated as the mechanism by which CD36 promote metastases dissemination and growth. Also provided is a method for identifying candidates to anticancer agents, particularly for OSCC metastasis, among those that promote in CD36+ cells, in vivo or in vitro, effects associated to CD36 depletion or blocking such as decrease of growth accumulation of lipid droplets and decrease of size in the case of metastases.

The invention relates to a collection of signature peptides representing at least 10 proteins for use in cancer diagnosis and/or prognosis, to an artificial protein comprising signature peptides representing at least 10 proteins and to a nucleic acid construct encoding for such an artificial protein. The invention further relates to a collection of at least 10 proteins for use in cancer diagnosis and/or prognosis. Additionally, the invention relates to a method for cancer diagnosis and/or prognosis comprising the step of analyzing at least 10 proteins in a urine sample of a subject. Finally, the invention relates to an immunoassay product comprising antibodies for detecting at least 10 proteins.

The present invention features the application of a simple, inductively-coupled measurement system into the cap of standard laboratory sample tubes, thus enabling continuous, wireless ionic sensing of a bevy of samples. The system may be powered by a compact Class E amplifier using inductive coupling via a designed resonance frequency of 1 MHz. Other frequencies can be used, such as the popular near-field communication (NFC) frequency of 13.66 MHz. Signals are transmitted back via load modulation at frequencies a fraction of the power carrier frequency, thus allowing for extraction of the signal frequency. Results clearly show that modulation frequency tracks closely with open circuit potential, and the system features good sensitivity and linearity. This system holds promise for a host of applications.

A method for automating process development in a bioprocessing environment is provided. The method comprising: executing a first experiment run according to a set of parameters; retrieving a first real-time set of data of the experiment run while the experiment run is being executed; retrieving a second real-time set of data of an experiment run being executed in parallel, analysing the retrieved first real-time set of data and the second real-time set of data to determine an adjusted set of parameters; and, modifying, based on the analysis, the parameters upon which the experiment run is being executed during execution of the run such that the run continues to be executed according to the modified set of parameters. A system, computer program and computer readable medium are also provided.

A method for automating process development in a bioprocessing environment is provided. The method comprising: executing a first experiment run according to a set of parameters; retrieving a first real-time set of data of the experiment run while the experiment run is being executed; retrieving a second real-time set of data of an experiment run being executed in parallel, analysing the retrieved first real-time set of data and the second real-time set of data to determine an adjusted set of parameters; and, modifying, based on the analysis, the parameters upon which the experiment run is being executed during execution of the run such that the run continues to be executed according to the modified set of parameters. A system, computer program and computer readable medium are also provided.

At least one binding site of a protein is probed by calculating a set of molecular dynamic trajectories of a protein-ligand complex family. At least one script is applied to the molecular dynamic trajectories to form a set of tensors, and at least one second script is applied to the set of tensors to integrate the set of tensors with experimental binding data corresponding to the protein-ligand complex family to form a primary image of the binding site, thereby probing the binding site of the protein.