Patent classifications
C12Y304/17021
Multiple Proteases Deficient Filamentous Fungal Cells and Methods of Use Thereof
The present disclosure relates to compositions and methods useful for the production of heterologous proteins in filamentous fungal cells.
PSMA-BASED MOLECULAR-GENETIC REPORTER SYSTEM
Methods, reporter gene constructs, and kits for using prostate-specific membrane antigen (PSMA) as an imaging reporter to image a variety of cells and tissues are provided.
PSMA BINDING LIGAND-LINKER CONJUGATES AND METHODS FOR USING
Described herein are prostate specific membrane antigen (PSMA) binding conjugates that are useful for delivering therapeutic, diagnostic and imaging agents. Also described herein are pharmaceutical compositions containing them and methods of using the conjugates and compositions. Also described are processes for manufacture of the conjugates and the compositions containing them.
Multiple proteases deficient filamentous fungal cells and methods of use thereof
The present disclosure relates to compositions and methods useful for the production of heterologous proteins in filamentous fungal cells.
VACCINIA VIRUS FOR GENE-DIRECTED ENZYME PRODRUG THERAPY
Methods of making vaccinia viruses for gene-directed prodrug therapy are disclosed and their use in the treatment of disease is provided. In particular, the anti-tumour effects of vaccinia viruses that are modified to express a prodrug activating enzyme are disclosed.
INDUCED ACTIVATION IN DENDRITIC CELLS
The present invention is directed to a composition and method which to treat diseases and to enhance a regulated immune response. More particularly, the present invention is drawn to compositions that are based on dendritic cells modified to express an inducible form of a co-stimulatory polypeptide.
THERANOSTIC CAPTURE AGENTS, COMPOSITIONS, AND METHODS OF USING AND MAKING
Disclosed are compounds, compositions, and methods involving theranostic capture agent for a target where the capture agent is (a) a precursor that can be loaded with a detectable moiety, a therapeutic moiety, or both, (b) loaded with a detectable moiety, (c) loaded with a therapeutic moiety, or (d) loaded with both a detectable moiety and a therapeutic moiety. Also disclosed are stable peptide-based PSMA capture agents and methods of use as detection agents.
Multiple Proteases Deficient Filamentous Fungal Cells and Methods of Use Thereof
The present disclosure relates to compositions and methods useful for the production of heterologous proteins in filamentous fungal cells.
COMPOSITIONS AND METHODS COMPRISING KLK3 OR FOLH1 ANTIGEN
The present invention provides KLK3 peptides, FOLH1 peptides, recombinant polypeptides comprising same, recombinant nucleotide molecules encoding same, recombinant Listeria strains comprising same, and immunogenic and therapeutic methods utilizing same.
Multiple protease deficient filamentous fungal cells and methods of use thereof
The present disclosure relates to compositions and methods useful for the production of heterologous proteins in filamentous fungal cells.