A process for selective capture of CO.sub.2 from gaseous mixture comprising of: (a) spraying a bio-amine cluster; (b) capturing CO.sub.2 through bio-amine cluster; and (c) desorption of CO.sub.2 through solar assisted electro de-amination, wherein the bio-amine cluster is comprises of: an amine cluster comprising of a quaternary Isobutylamine (IB) with amine terminated Poly(L-lactide) as the chelating agent; a cluster stabilizing agent; a cluster micelle stabilizing agent; and a carbonic anhydrase (CA) functionalized matrix in 0.05-0.2 wt % of total wt % of bio-amine cluster and wherein the CA is obtained from a source selected from the group consisting of Bacillus thermoleovorans, Pseudomonas fragi, Bacillus stearothermophilus and Arthrobacter sp. and a process for production of bio-amine cluster.

Provided herein are compositions of carbonic anhydrase and inhibitors thereof for the treatment of subjects with certain conditions such as heart disease.

The present disclosure provides drug responsive domains derived from human carbonic anhydrase 2 that can modulate protein stability for human interleukin 15 (EL15) payloads, as well as compositions and methods of use thereof.

Provided is a method of producing and isolating a diamine produced by microbial fermentation that minimizes undesirable salt formation to provide a lower cost process.

A transcriptomic analysis of genes consistently upregulated in high producer clones were each evaluated for their ability to increase the production of a protein of interest. The products of these genes (metabolism influencing products (MIP)), such as actin, Erp27, Erp57, Foxa1, PPAR, Ca3, and Tagap, could be sub-categorized into different functional categories such as signaling, protein folding, cytoskeleton organization and cell survival.

Methods for repair of cracks and niches in concrete using carbonic anhydrase embedded in a gelatin, hydrogel, or other aqueous matrix are provided. A durable corrosion resistant concrete mix containing carbonic anhydrase is provided, as are methods of making and using the durable corrosion resistant concrete. Corrosion resistance and durability derive from decreased porosity compared to concrete without the enzyme, conferring decreased access of deleterious materials such as chloride ions to interior portions of the concrete.

The present disclosure relates to compounds that are useful as near-infrared fluorescence probes, wherein the compounds include i) a ligand that binds to the active site of carbonic anhydrase, ii) a dye molecule, and iii) a linker molecule that comprises an amino acid, amide, ureido, or polyethylene glycol derivative thereof. The disclosure further describes methods and compositions for making and using the compounds, methods incorporating the compounds, and kits incorporating the compounds.

The present invention relates to epitopes located in CAIX and anti-CAIX antibodies having binding activity with cancer cells. The present invention also relates to the composition and application of the CAIX epitopes and anti-CAIX antibodies in the diagnosis, prevention and/or treatment of cancers.

The present invention provides compounds, compositions thereof, and methods of using the same.

The present disclosure provides regulatable biocircuit systems. Such systems provide modular and tunable protein expression systems in support of the discovery and development of therapeutic modalities.