The invention relates to a process for the preparation of one or more intermediate chemical compounds useful in the preparation of non-ionic contrast agents wherein the process is carried out continuously using one or more flow procedures.

The invention relates to a process for the preparation of one or more intermediate chemical compounds useful in the preparation of non-ionic contrast agents wherein the process is carried out continuously using one or more flow procedures.

The regio-selective functionalization of a dialkyl benzene compound ##STR00001##
wherein the ratio of the compound functionalized at position (a) to the compound functionalized at the position (b) is at least 70:30, more particularly at least 80:20, still more particularly at least 85:15, and still more particularly at least 90:10, characterised in that the substituent R is an isobutyl group.

The regio-selective functionalization of a dialkyl benzene compound ##STR00001##
wherein the ratio of the compound functionalized at position (a) to the compound functionalized at the position (b) is at least 70:30, more particularly at least 80:20, still more particularly at least 85:15, and still more particularly at least 90:10, characterised in that the substituent R is an isobutyl group.

The regio-selective functionalization of a dialkyl benzene compound ##STR00001##
wherein the ratio of the compound functionalized at position (a) to the compound functionalized at the position (b) is at least 70:30, more particularly at least 80:20, still more particularly at least 85:15, and still more particularly at least 90:10, characterised in that the substituent R is an isobutyl group.

The present invention provides a process for preparation of halo substituted benzoic acid compound of Formula (1) and intermediates thereof. ##STR00001##

The present invention provides a process for preparation of halo substituted benzoic acid compound of Formula (1) and intermediates thereof. ##STR00001##

Methods of CH bond fluorination using non-heme manganese catalyst are described herein. For example, a method comprises providing a reaction mixture including a non-heme manganese catalyst, a substrate comprising an sp.sup.3 CH bond and a fluorinating agent and converting the sp.sup.3 CH bond to a CF bond in the presence of the non-heme manganese catalyst or a derivative thereof.

The present invention provides a process for preparation of halo substituted benzoic acid compound of Formula (1) and intermediates thereof.

##STR00001##

The present invention provides a process for preparation of halo substituted benzoic acid compound of Formula (1) and intermediates thereof.

##STR00001##