The present invention is directed to novel fragrance compounds and their unexpected advantageous use in improving, enhancing or modifying a fragrance formulation through the addition of an olfactory acceptable amount of the compounds, wherein the compounds are represented by the following formula: ##STR00001## an isomer or a mixture of isomers thereof, wherein one of R and R′ represents hydrogen with the other representing a C.sub.1-C.sub.6 linear, branched, or cyclic alkyl, alkenyl, alkynyl or aromatic group; and one of the dashed lines represents a carbon-carbon single bond with the other representing a carbon-carbon double bond.

The invention provides methods of synthesizing a viral protease inhibitor in high yield, without using expensive catalysts or challenging reaction conditions.

The invention provides methods of synthesizing a viral protease inhibitor in high yield, without using expensive catalysts or challenging reaction conditions.

A method of preparing a compound of formula (IV)

##STR00001##

where R.sub.1 is alkyl of 1 to 4 carbon atoms, comprises reacting cyclohexene with hydrogen peroxide and an alcohol R.sub.1OH in the presence of a catalyst comprising a zeolite of framework structure MWW, wherein the framework of the zeolite comprises silicon, titanium, boron, oxygen and hydrogen.

A method of preparing a compound of formula (IV)

##STR00001##

where R.sub.1 is alkyl of 1 to 4 carbon atoms, comprises reacting cyclohexene with hydrogen peroxide and an alcohol R.sub.1OH in the presence of a catalyst comprising a zeolite of framework structure MWW, wherein the framework of the zeolite comprises silicon, titanium, boron, oxygen and hydrogen.

A method of preparing 2-alkoxycyclohexanol, a mixture comprising 2-alkoxycyclohexanol obtained via said method, and the use of said mixture for preparing 4-hydroxy-3-alkoxy-benzaldehyde.

A method of preparing 2-alkoxycyclohexanol, a mixture comprising 2-alkoxycyclohexanol obtained via said method, and the use of said mixture for preparing 4-hydroxy-3-alkoxy-benzaldehyde.

A polyether diol compound represented by the following formula (3):

##STR00001##

where R.sup.5, R.sup.6, R.sup.7 and R.sup.8, which may be the same as or different from each other, each represent a linear or branched alkyl group having 1 to 6 carbon atoms.

A polyether diol compound represented by the following formula (3):

##STR00001##

where R.sup.5, R.sup.6, R.sup.7 and R.sup.8, which may be the same as or different from each other, each represent a linear or branched alkyl group having 1 to 6 carbon atoms.

This disclosure relates to trans-cyclooctene compounds and methods of using the same in bioorthogonal labeling experiments.