Provided is a rubber composition that has better weather resistance than conventional rubber compositions and can inhibit rubber article surface discoloration. The rubber composition contains at least one rubber component selected from natural rubber and diene-based synthetic rubbers and, blended therewith, at least one bisphenyldiamine compound represented by formula (I). In formula (I), R.sup.1, R.sup.2, R.sup.5, and R.sup.6 each represent, independently of one another, a hydrogen atom, an alkyl group having a carbon number of 1-10, or a phenyl group, but R.sup.1 and R.sup.2 do not both simultaneously represent a hydrogen atom and R.sup.5 and R.sup.6 do not both simultaneously represent a hydrogen atom, R.sup.3 and R.sup.4 each represent, independently of one another, an alkyl group having a carbon number of 1-8 or an aralkyl group, A represents an alkylene group having a carbon number of 1-12, and l, m, and n each represent an integer of 0 or 1. ##STR00001##

The disclosure provides methods of use of certain compounds that are useful for treating certain symptoms of endocrine disturbances, and in particular those associated with hot flashes.

The disclosure provides methods of use of certain compounds that are useful for treating certain symptoms of endocrine disturbances, and in particular those associated with hot flashes.

The present disclosure relates to a novel active compound having the formula Ia: ##STR00001##
solid preparations, uses and methods for the treatment or prevention of respiratory diseases comprising said compound as well as process of preparation thereof.

The present disclosure relates to a novel active compound having the formula Ia: ##STR00001##
solid preparations, uses and methods for the treatment or prevention of respiratory diseases comprising said compound as well as process of preparation thereof.

Provided are a compound capable of degrading a target protein using ubiquitin and having a targeted protein binding moiety (TBM) structure binding to a target protein or polypeptide and a ubiquitin binding moiety (UBM) structure to which ubiquitin is bound, wherein the compound can be induced to polyubiquitination by the UBM structure present in the compound, and thus have an advantage of becoming a protein degrader capable of degrading a target protein or polypeptide.

Provided are a compound capable of degrading a target protein using ubiquitin and having a targeted protein binding moiety (TBM) structure binding to a target protein or polypeptide and a ubiquitin binding moiety (UBM) structure to which ubiquitin is bound, wherein the compound can be induced to polyubiquitination by the UBM structure present in the compound, and thus have an advantage of becoming a protein degrader capable of degrading a target protein or polypeptide.

Triphenylethylene compounds of formula (II) ##STR00001##
as dual aromatase inhibitors and selective estrogen receptors modulators are described. Also described are methods for treating patients of breast cancers, and patients of breast cancer comorbid with osteoporosis, using the described triphenylethylence compounds or pharmaceutical formulations thereof.

The present invention relates to chemical compounds of formula (I), with the substituents as described in the specification, useful in the positive modulation of the alpha 7 nicotinic acetylcholine receptor (7 nAChR). The invention also relates to the use of these compounds in the treatment or prevention of a broad range of diseases in which the positive modulation of 7 nAChR is advantageous, including neurodegenerative and neuropsychiatric diseases and also neuropathic pain and inflammatory diseases. ##STR00001##

The present invention relates generally to catalysts and processes for the Z-selective formation of internal olefin(s) from terminal olefin(s) via homo-metathesis reactions.