The present invention relates in part to novel cationic lipids and their use, e.g., in delivering nucleic acids to cells.

The present invention relates in part to novel cationic lipids and their use, e.g., in delivering nucleic acids to cells.

The present invention relates in part to novel cationic lipids and their use, e.g., in delivering nucleic acids to cells.

A linker of bioprobes, suitable for immobilizing a bioprobe on a chip substrate of a sensor, includes SH(CH)n-NH2, SH(CH)n-COOH, SH(CH)n-SH, (OH)m-(CH)n-COOH or (OH)m-(CH)n-NH2, having a carbon number of 6 or more, m and n being integers greater than 1. When an average surface roughness (Ra) of the chip substrate is greater than 250 nm, coverage of the linker on the chip substrate is 40%-80%. A further linker of bioprobes, includes SH(CH)n-NH2, SH(CH)n-COOH, SH(CH)n-SH, (OH)m-(CH)n-COOH or (OH)m-(CH)n-NH2, having a carbon number of less than 6, m and n being integers greater than 1. When an average surface roughness (Ra) of the chip substrate is less than 250 nm, coverage of the linker on the chip substrate is 65%-100%. The optimal carbon chain length of the linker and the coverage are realized for substrates of various roughnesses, and grasping ability of an electrochemical sensor chip for a detected object are enhanced.

A linker of bioprobes, suitable for immobilizing a bioprobe on a chip substrate of a sensor, includes SH(CH)n-NH2, SH(CH)n-COOH, SH(CH)n-SH, (OH)m-(CH)n-COOH or (OH)m-(CH)n-NH2, having a carbon number of 6 or more, m and n being integers greater than 1. When an average surface roughness (Ra) of the chip substrate is greater than 250 nm, coverage of the linker on the chip substrate is 40%-80%. A further linker of bioprobes, includes SH(CH)n-NH2, SH(CH)n-COOH, SH(CH)n-SH, (OH)m-(CH)n-COOH or (OH)m-(CH)n-NH2, having a carbon number of less than 6, m and n being integers greater than 1. When an average surface roughness (Ra) of the chip substrate is less than 250 nm, coverage of the linker on the chip substrate is 65%-100%. The optimal carbon chain length of the linker and the coverage are realized for substrates of various roughnesses, and grasping ability of an electrochemical sensor chip for a detected object are enhanced.

A perfluorinated 1-alkoxypropene represented by general Formula (I), compositions that include such compounds, and methods and systems that include such compositions are provided, wherein Formula (I) is represented by: R.sub.fOCFCFCF.sub.3 wherein R.sub.f is a linear, branched, or cyclic perfluoroalkyl group having 2 to 10 carbon atoms and optionally further including 1 to 3 nitrogen and/or 1 to 4 oxygen catenary heteroatoms.

The present invention relates in part to novel cationic lipids and their use, e.g., in delivering nucleic acids to cells.

The present invention relates in part to novel cationic lipids and their use, e.g., in delivering nucleic acids to cells.

In one aspect, the present disclosure relates to click-functional antimicrobial molecules (including small molecules or, in some cases, macromolecules) and the construction of antimicrobial polymers such as polyurethanes, polyesters, and polyacrylates, including through the use of such molecules. In some cases, the antimicrobial click-functional molecules are based on 1,2-benzisothiazolin-3-one (BIT), trimethylguanidine or tetramethylguanidine (TMG), polyhexamethylene guanidine (PHMG), fluorine-containing molecules, or a combination thereof. For example, 1,2-benzisothiazolin-3-one (BIT) functionalized with an alkyne (BIT-Al), trimethylguanidine or tetramethylguanidine (TMG) functioned with an alkyne (TMG-Al) or dual alkynes (TMG-dAl), and/or polyhexamethylene guanidine (PHMG) functionalized with an alkyne (PHMG-Al) are described herein. Clickable antimicrobial polymers can be used to form coatings or films.

In one aspect, the present disclosure relates to click-functional antimicrobial molecules (including small molecules or, in some cases, macromolecules) and the construction of antimicrobial polymers such as polyurethanes, polyesters, and polyacrylates, including through the use of such molecules. In some cases, the antimicrobial click-functional molecules are based on 1,2-benzisothiazolin-3-one (BIT), trimethylguanidine or tetramethylguanidine (TMG), polyhexamethylene guanidine (PHMG), fluorine-containing molecules, or a combination thereof. For example, 1,2-benzisothiazolin-3-one (BIT) functionalized with an alkyne (BIT-Al), trimethylguanidine or tetramethylguanidine (TMG) functioned with an alkyne (TMG-Al) or dual alkynes (TMG-dAl), and/or polyhexamethylene guanidine (PHMG) functionalized with an alkyne (PHMG-Al) are described herein. Clickable antimicrobial polymers can be used to form coatings or films.