Patent classifications
C07C215/50
Compounds for use in the elimination of pluripotent stem cells
The present invention relates to a method of reducing the number or percentage of pluripotent stem cells or of enriching differentiating or differentiated cells in a cell population comprising pluripotent stem cells and differentiating cells or differentiated cells derived from the pluripotent stem cells, the method comprising the step of contacting the cell population with a compound according to the general formula (1).
Hydrogen-bonding compounds, compositions comprising the same, and methods of preparing and using the same
Described herein are compounds having a hydrogen-bonding group and optionally a functional group for binding (e.g., covalently binding) the compound to another compound (e.g., hyaluronic acid and/or gelatin). A compound of the present invention may have a structure represented by and/or comprising Formula I, Formula II, Formula III, Formula IV, Formula IV′, Formula V, Formula V′, Formula VI, Formula VII, and/or Formula VIII as described herein. Compositions including compounds of the present invention along with methods of preparing and using the same are also described herein.
Hydrogen-bonding compounds, compositions comprising the same, and methods of preparing and using the same
Described herein are compounds having a hydrogen-bonding group and optionally a functional group for binding (e.g., covalently binding) the compound to another compound (e.g., hyaluronic acid and/or gelatin). A compound of the present invention may have a structure represented by and/or comprising Formula I, Formula II, Formula III, Formula IV, Formula IV′, Formula V, Formula V′, Formula VI, Formula VII, and/or Formula VIII as described herein. Compositions including compounds of the present invention along with methods of preparing and using the same are also described herein.
TRIPHENYLPHOSPHONIUM-TETHERED SALICYLAMINE DERIVATIVES
Novel salicylamine derivatives are targeted directly to the mitochondria to increase effectiveness and lower required dosages in the treatment of conditions caused by inflammation or oxidative stress.
TRIPHENYLPHOSPHONIUM-TETHERED SALICYLAMINE DERIVATIVES
Novel salicylamine derivatives are targeted directly to the mitochondria to increase effectiveness and lower required dosages in the treatment of conditions caused by inflammation or oxidative stress.
PREPARATION METHOD OF CARDANOL-MODIFIED POLYAMINE CURING AGENT WITH HIGH CORROSION RESISTANCE
The present invention discloses a preparation method of a cardanol-modified polyamine curing agent with high corrosion resistance. The method includes the following steps: subjecting cardanol, paraformaldehyde and an amine compound to Mannich reaction, after the Mannich reaction, adding a water-soluble initiator for polymerization reaction, then evaporating water and excessive amine compound under reduced pressure after the polymerization reaction, thus obtaining a cardanol-modified polyamine curing agent. The coating obtained by curing the curing agent with an epoxy resin has greatly improved chemical resistance and corrosion resistance, indicating that the use of the water-soluble initiator in this present invention enables olefins to be polymerized very well, and molecules are reinforced obviously after polymerization, thereby greatly improving the chemical resistance and corrosion resistance.
PREPARATION METHOD OF CARDANOL-MODIFIED POLYAMINE CURING AGENT WITH HIGH CORROSION RESISTANCE
The present invention discloses a preparation method of a cardanol-modified polyamine curing agent with high corrosion resistance. The method includes the following steps: subjecting cardanol, paraformaldehyde and an amine compound to Mannich reaction, after the Mannich reaction, adding a water-soluble initiator for polymerization reaction, then evaporating water and excessive amine compound under reduced pressure after the polymerization reaction, thus obtaining a cardanol-modified polyamine curing agent. The coating obtained by curing the curing agent with an epoxy resin has greatly improved chemical resistance and corrosion resistance, indicating that the use of the water-soluble initiator in this present invention enables olefins to be polymerized very well, and molecules are reinforced obviously after polymerization, thereby greatly improving the chemical resistance and corrosion resistance.
COMPOUNDS WITH ANTIMICROBIAL ACTIVITY
This invention relates to compounds of formula 1, 2 or 3
##STR00001##
a pharmaceutically acceptable salt, or solvate thereof, wherein X.sub.1, Y, R.sub.1, R.sub.2, R.sub.3, R.sub.4, and R.sub.5 are as defined herein. The compounds are antimicrobial agents that may be used to treat various bacterial and protozoal infections and disorders related to such infections. The invention also relates to pharmaceutical compositions containing the compounds and to methods of treating bacterial and protozoal infections by administering the compounds of formula 1, 2 or 3.
COMPOUNDS WITH ANTIMICROBIAL ACTIVITY
This invention relates to compounds of formula 1, 2 or 3
##STR00001##
a pharmaceutically acceptable salt, or solvate thereof, wherein X.sub.1, Y, R.sub.1, R.sub.2, R.sub.3, R.sub.4, and R.sub.5 are as defined herein. The compounds are antimicrobial agents that may be used to treat various bacterial and protozoal infections and disorders related to such infections. The invention also relates to pharmaceutical compositions containing the compounds and to methods of treating bacterial and protozoal infections by administering the compounds of formula 1, 2 or 3.
METHODS FOR TREATING INFLAMMATION AND HYPERTENSION WITH GAMMA-KETOALDEHYDE SKAVENGERS
A method of treating at least one of inflammation, psoriasis, and/or hypertension comprising administering to a patient in need there of an effective gamma-ketoaldehyde scavenging amount of a gamma-ketoaldehyde scavenging compound.